Stem cell gene expression programs influence clinical outcome in human leukemia

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

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Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

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Prognostically Useful Gene-Expression Profiles in Acute Myeloid Leukemia

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The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

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Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

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Disruption of differentiation in human cancer: AML shows the way

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Anti-CD38 antibody–mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

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Lack of Expression of Thy-1 (CD90) on Acute Myeloid Leukemia Cells With Long-Term Proliferative Ability In Vitro and In Vivo

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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

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Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

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Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

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Cancer stem cells in glioblastoma

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

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Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

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A 17-gene stemness score for rapid determination of risk in acute leukaemia

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Hematopoiesis: a human perspective

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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

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Targeting Cancer Stemness in the Clinic: From Hype to Hope

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BET inhibitor resistance emerges from leukaemia stem cells

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Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

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Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

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BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

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A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

Bahr, C., von Paleske, L., Uslu, V. V., Remeseiro, S., Takayama, N., Ng, S. W., Murison, A., Langenfeld, K., Petretich, M., Scognamiglio, R., et al. (2018) · Nature · doi:10.1038/nature25193 · Cited by 328

Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence

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SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

Krivtsov, A. V., Figueroa, M. E., Sinha, A. U., Stubbs, M. C., Feng, Z., Valk, P. J. M., Delwel, R., Döhner, K., Bullinger, L., Kung, A. L., et al. (2013) · Leukemia · doi:10.1038/leu.2012.363 · Cited by 203

Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion

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Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

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An integrative ENCODE resource for cancer genomics

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Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

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Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

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Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a -Mutant Clonal Hematopoiesis

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Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs

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A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers

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The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML

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Hydrogel microstructure live-cell array for multiplexed analyses of cancer stem cells, tumor heterogeneity and differential drug response at single-element resolution

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GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells

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