Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

Generation of a functional mammary gland from a single stem cell

Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K., Asselin-Labat, M.-L., Wu, L., Lindeman, G. J., & Visvader, J. E. (2006) · Nature · doi:10.1038/nature04372 · Cited by 2,005

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

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An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

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Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

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Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

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Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

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Oxidants, antioxidants and the current incurability of metastatic cancers

Watson, J. (2013) · Open Biology · doi:10.1098/rsob.120144 · Cited by 354

Protein tyrosine phosphatases as potential therapeutic targets

He, R.-J., Yu, Z.-H., Zhang, R.-Y., & Zhang, Z.-Y. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.80 · Cited by 327

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

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Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

HATAKEYAMA, M. (2017) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.93.013 · Cited by 261

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

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SHP2 sails from physiology to pathology

Tajan, M., de Rocca Serra, A., Valet, P., Edouard, T., & Yart, A. (2015) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2015.08.005 · Cited by 232

Therapeutic targeting of oncogenic tyrosine phosphatases

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SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade

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Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Wang, M., Lu, J., Wang, M., Yang, C.-Y., & Wang, S. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00471 · Cited by 172

Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials

Song, Y., Zhao, M., Zhang, H., & Yu, B. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107966 · Cited by 125

A comprehensive review of SHP2 and its role in cancer

Asmamaw, M. D., Shi, X.-J., Zhang, L.-R., & Liu, H.-M. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00698-1 · Cited by 119

Hepatic stellate cell–derived platelet‐derived growth factor receptor‐alpha‐enriched extracellular vesicles promote liver fibrosis in mice through SHP2

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New structural and functional insight into the regulation of Ras

Kano, Y., Cook, J. D., Lee, J. E., & Ohh, M. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2016.06.006 · Cited by 38

Shp2-mediated MAPK pathway regulates ΔNp63 in epithelium to promote corneal innervation and homeostasis

Okada, Y., Zhang, Y., Zhang, L., Yeh, L.-K., Wang, Y.-C., Saika, S., & Liu, C.-Y. (2020) · Laboratory Investigation · doi:10.1038/s41374-019-0338-2 · Cited by 13

SHP2: a new target for pro‐senescence cancer therapies

Serrano, M. (2015) · The EMBO Journal · doi:10.15252/embj.201591616 · Cited by 12