The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction
Open accessAbstract
Acute myocardial infarction is a severe ischemic disease responsible for heart failure and sudden death. Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6Chi monocyte mobilization and recruitment to the heart, leading to enhanced tissue injury and deterioration of myocardial function. Genetic (Baff receptor deficiency) or antibody-mediated (CD20- or Baff-specific antibody) depletion of mature B lymphocytes impeded Ccl7 production and monocyte mobilization, limited myocardial injury and improved heart function. These effects were recapitulated in mice with B cell–selective Ccl7 deficiency. We also show that high circulating concentrations of CCL7 and BAFF in patients with acute myocardial infarction predict increased risk of death or recurrent myocardial infarction. This work identifies a crucial interaction between mature B lymphocytes and monocytes after acute myocardial ischemia and identifies new therapeutic targets for acute myocardial infarction.
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Genetic Determinants of Response to Clopidogrel and Cardiovascular Events
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Self-citationA Tale of Coronary Artery Disease and Myocardial Infarction
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Cardioimmunology: the immune system in cardiac homeostasis and disease
Swirski, F. K., & Nahrendorf, M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0065-8 · Cited by 849
Hilgendorf, I., Gerhardt, L. M. S., Tan, T. C., Winter, C., Holderried, T. A. W., Chousterman, B. G., Iwamoto, Y., Liao, R., Zirlik, A., Scherer-Crosbie, M., et al. (2014) · Circulation Research · doi:10.1161/circresaha.114.303204 · Cited by 559
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S. (2020) · Cells · doi:10.3390/cells10010051 · Cited by 401
Overexpression of the Cytokine BAFF and Autoimmunity Risk
Steri, M., Orrù, V., Idda, M. L., Pitzalis, M., Pala, M., Zara, I., Sidore, C., Faà, V., Floris, M., Deiana, M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1610528 · Cited by 382
Metadata
- Authors
- Zouggari, Y., Ait-Oufella, H., Bonnin, P., Simon, T., Sage, A. P., Guérin, C., Vilar, J., Caligiuri, G., Tsiantoulas, D., Laurans, L., Dumeau, E., Kotti, S., Bruneval, P., Charo, I. F., Binder, C. J., Danchin, N., Tedgui, A., Tedder, T. F., Silvestre, J.-S., & Mallat, Z.
- Venue
- Nature Medicine
- Published
- 2013-09-15
- Volume
- 19
- Issue
- 10
- Pages
- 1273-1280
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2064752763
- Cited by
- 559
- References
- 45
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Zouggari, Y., Ait-Oufella, H., Bonnin, P., Simon, T., Sage, A. P., Guérin, C., Vilar, J., Caligiuri, G., Tsiantoulas, D., Laurans, L., Dumeau, E., Kotti, S., Bruneval, P., Charo, I. F., Binder, C. J., Danchin, N., Tedgui, A., Tedder, T. F., Silvestre, J.-S., & Mallat, Z. (2013). B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nature Medicine. https://doi.org/10.1038/nm.3284
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