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Cited by 559

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

Open access
Zouggari, Yasmine, Ait-Oufella, Hafid, Bonnin, Philippe, Simon, Tabassome, Sage, Andrew P, Guérin, Coralie, Vilar, José, Caligiuri, Giuseppina, Tsiantoulas, Dimitrios, Laurans, Ludivine, Dumeau, Edouard, Kotti, Salma, Bruneval, Patrick, Charo, Israel F, Binder, Christoph J, Danchin, Nicolas, Tedgui, Alain, Tedder, Thomas F, Silvestre, Jean-Sébastien, Mallat, Ziad·2013·Nature Medicine
DOI 10.1038/nm.3284
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Abstract

Acute myocardial infarction is a severe ischemic disease responsible for heart failure and sudden death. Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6Chi monocyte mobilization and recruitment to the heart, leading to enhanced tissue injury and deterioration of myocardial function. Genetic (Baff receptor deficiency) or antibody-mediated (CD20- or Baff-specific antibody) depletion of mature B lymphocytes impeded Ccl7 production and monocyte mobilization, limited myocardial injury and improved heart function. These effects were recapitulated in mice with B cell–selective Ccl7 deficiency. We also show that high circulating concentrations of CCL7 and BAFF in patients with acute myocardial infarction predict increased risk of death or recurrent myocardial infarction. This work identifies a crucial interaction between mature B lymphocytes and monocytes after acute myocardial ischemia and identifies new therapeutic targets for acute myocardial infarction.

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Metadata

Authors
Zouggari, Y., Ait-Oufella, H., Bonnin, P., Simon, T., Sage, A. P., Guérin, C., Vilar, J., Caligiuri, G., Tsiantoulas, D., Laurans, L., Dumeau, E., Kotti, S., Bruneval, P., Charo, I. F., Binder, C. J., Danchin, N., Tedgui, A., Tedder, T. F., Silvestre, J.-S., & Mallat, Z.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2013-09-15
Volume
19
Issue
10
Pages
1273-1280
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3284
OpenAlex
W2064752763
Cited by
559
References
45
FWCI
20.55
Type
journal article
Language
en
Open access
green

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