The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
HIV-1 persistence in CD4+ T cells with stem cell–like properties
Open accessAbstract
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence.
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Self-citation
Metadata
- Authors
- Buzon, M. J., Sun, H., Li, C., Shaw, A., Seiss, K., Ouyang, Z., Martin-Gayo, E., Leng, J., Henrich, T. J., Li, J. Z., Pereyra, F., Zurakowski, R., Walker, B. D., Rosenberg, E. S., Yu, X. G., & Lichterfeld, M.
- Venue
- Nature Medicine
- Published
- 2014-01-12
- Volume
- 20
- Issue
- 2
- Pages
- 139-142
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2044273929
- Cited by
- 414
- References
- 30
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- green
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