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HIV-1 persistence in CD4+ T cells with stem cell–like properties
Open accessAbstract
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence.
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Cites
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,730
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Finzi, D., Blankson, J., Siliciano, J. D., Margolick, J. B., Chadwick, K., Pierson, T., Smith, K., Lisziewicz, J., Lori, F., Flexner, C., et al. (1999) · Nature Medicine · doi:10.1038/8394 · Cited by 2,119
Self-citationHu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,083
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974 · cited 3×
“These experiments demonstrated that CD4 + T SCM cells, phenotypically defined as described in previous studies 10,14 and in Supplementary Figure 1, were approximately as susceptible as CD4 + T CM cells to infection with an R5-tropic HIV-1 isolate (Fig.”
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Chomont, N., El-Far, M., Ancuta, P., Trautmann, L., Procopio, F. A., Yassine-Diab, B., Boucher, G., Boulassel, M.-R., Ghattas, G., Brenchley, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1972 · Cited by 1,722
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Ho, Y.-C., Shan, L., Hosmane, N. N., Wang, J., Laskey, S. B., Rosenbloom, D. I. S., Lai, J., Blankson, J. N., Siliciano, J. D., & Siliciano, R. F. (2013) · Cell · doi:10.1016/j.cell.2013.09.020 · Cited by 1,405
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
Gattinoni, L., Zhong, X.-S., Palmer, D. C., Ji, Y., Hinrichs, C. S., Yu, Z., Wrzesinski, C., Boni, A., Cassard, L., Garvin, L. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1982 · Cited by 1,031
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
Cieri, N., Camisa, B., Cocchiarella, F., Forcato, M., Oliveira, G., Provasi, E., Bondanza, A., Bordignon, C., Peccatori, J., Ciceri, F., et al. (2013) · Blood · doi:10.1182/blood-2012-05-431718 · Cited by 625
J Buzón, M., Massanella, M., Llibre, J. M., Esteve, A., Dahl, V., Puertas, M. C., Gatell, J. M., Domingo, P., Paredes, R., Sharkey, M., et al. (2010) · Nature Medicine · doi:10.1038/nm.2111 · Cited by 551
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
Takahashi-Yanaga, F., & Kahn, M. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2943 · Cited by 499
Progressive differentiation and selection of the fittest in the immune response
Lanzavecchia, A., & Sallusto, F. (2002) · Nature Reviews Immunology · doi:10.1038/nri959 · Cited by 495
Host-reactive CD8+ memory stem cells in graft-versus-host disease
Zhang, Y., Joe, G., Hexner, E., Zhu, J., & Emerson, S. G. (2005) · Nature Medicine · doi:10.1038/nm1326 · Cited by 369
Superior T memory stem cell persistence supports long-lived T cell memory
Lugli, E., Dominguez, M. H., Gattinoni, L., Chattopadhyay, P. K., Bolton, D. L., Song, K., Klatt, N. R., Brenchley, J. M., Vaccari, M., Gostick, E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66327 · Cited by 302
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
Katlama, C., Deeks, S. G., Autran, B., Martinez-Picado, J., van Lunzen, J., Rouzioux, C., Miller, M., Vella, S., Schmitz, J. E., Ahlers, J., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60104-x · Cited by 295
Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
Fearon, D. T., Manders, P., & Wagner, S. D. (2001) · Science · doi:10.1126/science.1062589 · Cited by 265
Unravelling the mechanisms of durable control of HIV-1
Walker, B. D., & Yu, X. G. (2013) · Nature Reviews Immunology · doi:10.1038/nri3478 · Cited by 233
Self-citationPaiardini, M., Cervasi, B., Reyes-Aviles, E., Micci, L., Ortiz, A. M., Chahroudi, A., Vinton, C., Gordon, S. N., Bosinger, S. E., Francella, N., et al. (2011) · Nature Medicine · doi:10.1038/nm.2395 · Cited by 220
Lugli, E., Gattinoni, L., Roberto, A., Mavilio, D., Price, D. A., Restifo, N. P., & Roederer, M. (2013) · Nature Protocols · doi:10.1038/nprot.2012.143 · Cited by 202
The precursors of memory: models and controversies
Ahmed, R., Bevan, M. J., Reiner, S. L., & Fearon, D. T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2619 · Cited by 202
Detecting HIV-1 integration by repetitive-sampling -gag PCR
Liszewski, M. K., Yu, J. J., & O’Doherty, U. (2009) · Methods · doi:10.1016/j.ymeth.2009.01.002 · Cited by 158
Pasternak, A. O., Adema, K. W., Bakker, M. E., Jurriaans, S., Berkhout, B., Cornelissen, M. T. E., & Lukashov, V. V. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00055-08 · Cited by 148
Herbeck, J. T., Rolland, M., Liu, Y., McLaughlin, S., McNevin, J. P., Zhao, H. C., Wong, K., Stoddard, J. N., Raugi, D. N., Sorensen, S., et al. (2011) · Journal of Virology · doi:10.1128/jvi.02697-10 · Cited by 96
Josefsson, L., Eriksson, S., Sinclair, E., Ho, T. N., Killian, M., Epling, L., Shao, W., Lewis, B., Bacchetti, P., Loeb, L., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis301 · Cited by 96
Real-Time PCR Analysis of HIV-1 Replication Post-entry Events
Mbisa, J. L., Delviks‐Frankenberry, K. A., Thomas, J. A., Gorelick, R. J., & Pathak, V. K. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-170-3_5 · Cited by 81
Sharkey, M. E., Babič, D. Z., Greenough, T. C., Gulick, R. M., Kuritzkes, D. R., & Stevenson, M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001303 · Cited by 77
Alu-LTR Real-Time Nested PCR Assay for Quantifying Integrated HIV-1 DNA
Brussel, A., Delelis, O., & Sonigo, P. (2005) · Humana Press eBooks · doi:10.1385/1-59259-907-9:139 · Cited by 71
Comparison of standard PCR/cloning to single genome sequencing for analysis of HIV-1 populations
Jordan, M. R., Kearney, M. F., Palmer, S., Shao, W., Maldarelli, F. M., Coakley, E. P. G., Chappey, C., WANKE, C. A., & Coffin, J. M. (2010) · Journal of Virological Methods · doi:10.1016/j.jviromet.2010.04.030 · Cited by 64
Papatriantafyllou, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3098 · Cited by 7
T memory stem cells: looking for stem cells in an immune haystack.
Emerson, S. G. (2008) · PubMed Central · Cited by 1
Cited by
HIV-1 Integration Landscape during Latent and Active Infection
Cohn, L. B., Silva, I. T., Oliveira, T. Y., Rosales, R. A., Parrish, E. H., Learn, G. H., Hahn, B. H., Czartoski, J. L., McElrath, M. J., Lehmann, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.020 · Cited by 444
Self-citationInternational AIDS Society global scientific strategy: towards an HIV cure 2016
International AIDS Society Towards a Cure Working Group, Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4108 · Cited by 425
Self-citationCD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
Fromentin, R., Bakeman, W., Lawani, M. B., Khoury, G., Hartogensis, W., DaFonseca, S., Killian, M., Epling, L., Hoh, R., Sinclair, E., et al. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005761 · Cited by 422
Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice
Dash, P. K., Kaminski, R., Bella, R., Su, H., Mathews, S., Ahooyi, T. M., Chen, C., Mancuso, P., Sariyer, R., Ferrante, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10366-y · Cited by 295
Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells
Lee, G. Q., Orlova-Fink, N., Einkauf, K., Chowdhury, F. Z., Sun, X., Harrington, S., Kuo, H.-H., Hua, S., Chen, H.-R., Ouyang, Z., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93289 · Cited by 292
Self-citation
Metadata
- Authors
- Buzon, M. J., Sun, H., Li, C., Shaw, A., Seiss, K., Ouyang, Z., Martin-Gayo, E., Leng, J., Henrich, T. J., Li, J. Z., Pereyra, F., Zurakowski, R., Walker, B. D., Rosenberg, E. S., Yu, X. G., & Lichterfeld, M.
- Venue
- Nature Medicine
- Published
- 2014-01-12
- Volume
- 20
- Issue
- 2
- Pages
- 139-142
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2044273929
- Cited by
- 414
- References
- 30
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- green
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