The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Open accessAbstract
Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging and age-related disease, and it is an attractive target for therapeutic exploitation. A wealth of information about senescence in cultured cells has been acquired over the past half century; however, senescence in living organisms is poorly understood, largely because of technical limitations relating to the identification and characterization of senescent cells in tissues and organs. Furthermore, newly recognized beneficial signaling functions of senescence suggest that indiscriminately targeting senescent cells or modulating their secretome for anti-aging therapy may have negative consequences. Here we discuss current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and age-related diseases as well as disease therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These findings suggest that even in whole tissues where the number of senescent cells is small (most aged or diseased tissues contained 1%–3% senescent cells [33]), some of the genes of our core signature can be identified as differentially regulated.”
From Unmasking Transcriptional Heterogeneity in Senescent Cells (2017) · cites this paper as [33]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The SASP composition and strength varies substantially, depending on the duration of senescence, origin of the pro-senescence stimulus, and cell type (Childs et al., 2015).”
From Cellular Senescence: Defining a Path Forward (2019) · cites this paper as Childs et al., 2015
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The role of senescence in human disease is clear from cellular studies, while in vivo evidence is only now catching up”
From Cellular Senescence: Defining a Path Forward (2019) · cites this paper as Childs et al., 2015
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Evidence linking senescence to other common age-associated human diseases has recently emerged. These diseases include neurodegenerative disorders, glaucoma, cataract, atherosclerosis and cardiovascular disease, diabetes, osteoarthritis, pulmonary, and renal and liver fibrosis”
From Cellular Senescence: Defining a Path Forward (2019) · cites this paper as Childs et al., 2015
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Senescent cells contribute to aging and age-related pathologies21,22,23 through their senescence-associated secretory phenotype (SASP).24,25,26”
From Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex (2026) · cites this paper as [23]
In the citing paper
“Furthermore, senescent cell accumulation via aging-induced epigenetic, proteotoxic and genotoxic stresses usually exhibits a causal role in many age-related diseases, including glaucoma, cataracts, diabetes mellitus, osteoarthritis, among others (Childs et al. 2015).”
From Benefits of Metformin in Attenuating the Hallmarks of Aging (2020) · cites this paper as Childs et al. 2015
In the citing paper
“Cells can resume proliferation upon resolution of the stress (Childs et al., 2015).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Childs et al., 2015
In the citing paper
“The accumulation of senescent cells in ageing organisms contributes to many diseases, including cancer 46.”
From Cardiac glycosides are broad-spectrum senolytics (2019) · cites this paper as [46]
In the citing paper
“In vivo, the best currently available models for senescent cell detection are reporter-harbouring transgenic mice (p16-LUC, p16 tdTom)199,200 and transgenic mouse strains used for selective senescent cell removal (INK-ATTAC, p16-3MR).201”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [201]
In the citing paper
“Ageing is a significant risk factor for T2DM36”
From Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence (2024) · cites this paper as [36]
In the citing paper
“SCs accumulate with age and as a result of the exposure to a variety of stressors including radiation.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [1]
In the citing paper
“They play a causal role in many age-related diseases (such as neurodegenerative and cardiovascular diseases, osteoarthritis, and cancer) via expression of the senescence-associated secretory phenotype (SASP) to secret various inflammatory mediators and proteases1–7.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [1]
In the citing paper
“In many tissues, irreversibly cell cycle-arrested senescent cells accumulate during normal aging.”
From Aging of hematopoietic stem cells (2018) · cites this paper as [56]
In the citing paper
“In healthy aging, common cellular stresses can yield primary senescent cells that diminish tissue-repair capacity due to cell cycle arrest in progenitor cells and increase production of proinflammatory and matrix-degrading molecules (3, 4).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Natural lung aging is associated with molecular and physiological changes that cause alterations in lung function, diminished pulmonary remodeling and regenerative capacity, and increased susceptibility to acute and chronic lung diseases.”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Exposure to extrinsic time-related effects, such as chronic exposure to atmospheric pollution, dusts, particulates, and gases, induce low-level insults to cellular function and accelerate aging of the lung (3).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Age-associated changes in intrinsic mechanisms that aid in cell regeneration and repair, such as depletion of adult stem cell reservoirs, mitochondrial dysfunction, increased oxidative stress, and telomere shortening, contribute to an inability of lung cells to maintain baseline homeostasis.”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Senescent cells display a genetic and morphologic phenotype that is distinct from growth-competent cells and can have a detrimental impact on neighboring cells, structural components, and composition of the extracellular matrix (ECM) (3).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Excessive accumulation of senescent cells in numerous tissues leads to multiple chronic diseases, tissue dysfunction, age-related diseases and organ ageing.”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [12]
In the citing paper
“However, excessive accumulation of senescent cells causally shortens the healthy lifespan [11] and drives organ ageing [12], age-related organ deterioration/disorders [13,14], tissue dysfunction and chronic diseases, including cardiovascular diseases (CVDs) [15,16], cancer [2], neurodegenerative diseases [17,18] and osteoarthritis [19].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [12]
In the citing paper
“An age-associated increase in NK cell senescence has been shown to impair antiviral immune responses in response to influenza (3, 128).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Age-associated impairments in innate and adaptive immune responses in the lung may contribute to increased susceptibility of older persons developing an asthma exacerbation (3, 19, 107, 109, 110).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Further, age-associated changes in genomic instability, telomere shortening, epigenetic alterations, cellular senescence, impaired autophagy, and mitochondrial dysfunction may promote IPF development and progression (3, 12, 62, 84, 88, 89, 116, 145).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Age-associated immunosenescence and cellular senescence in response to exposure to cigarette smoke can greatly impact COPD pathogenesis (3, 19, 86).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Age-associated alterations in immune surveillance, specifically decreased innate and adaptive immune responses, and dysfunctional immune response regulation can be responsible for increased lung pathology in response to infectious stimuli (3, 62, 106, 110, 114, 135).”
From Aging and Lung Disease (2020) · cites this paper as [3]
In the citing paper
“Cellular senescence, a process that essentially entails permanent proliferative arrest of cells in response to various stressors, has emerged as a potentially important contributor to aging and age-related diseases and hence is a target of therapeutic interventions (3).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [3]
In the citing paper
“Importantly, removal of senescent cells promotes healthy aging in mice, making senescence‐associated inflammatory signaling an attractive target of therapeutic intervention for aging and age‐related disease (Tilstra et al, 2012; Childs et al, 2015; Baker et al, 2016; Ogrodnik et al, 2021).”
From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Childs et al, 2015
In the citing paper
“Notably, SA-β-gal in diverse types of senescent cells is one widely used marker for identifying senescence in vitro and in vivo, which is linked to the increased content of lysosomes.20–23”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [20]
In the citing paper
“While SA-β-gal is widely used as a marker of cellular senescence,20–22”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [20]
In the citing paper
“A challenge in targeting senescence is the apparent heterogeneity of this cellular state, wherein a variety of insults may incite senescence, the inflammatory secretory phenotype is modified depending on cell type, and the senescent phenotype may even change based on the stage of senescence [22–24].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
Nieto-Vazquez, I., Fernández-Veledo, S., de Alvaro, C., & Lorenzo, M. (2008) · Diabetes · doi:10.2337/db07-1062 · Cited by 209
RetractedThe serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Self-citationChimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
Grupp, S. A., Kalos, M., Barrett, D., Aplenc, R., Porter, D. L., Rheingold, S. R., Teachey, D. T., Chew, A., Hauck, B., Wright, J. F., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215134 · Cited by 3,509
Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., Finkelstein, E. A., Hong, Y., Johnston, S. C., Khera, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820a55f5 · Cited by 3,208
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,584
Flagged first, then by citations
Research works printed but not linked: 1
- Baker, D.J. et al. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat. Cell Biol. 10, 825–836 (2008). · DOI · Paper page
Cited by
Sorted by citations
Items 301–400 of 1,010
Age-related diseases as vicious cycles
Belikov, A. V. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.002 · Cited by 95
Functional heterogeneity in senescence
Kirschner, K., Rattanavirotkul, N., Quince, M. F., & Chandra, T. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190109 · Cited by 95
Age and Sex: Impact on adipose tissue metabolism and inflammation
Varghese, M., Song, J., & Singer, K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111563 · Cited by 100
Zampetidis, C., Galanos, P., Angelopoulou, A., Zhu, Y., Polyzou, A., Karamitros, T., Kotsinas, A., Lаgopati, N., Mourkioti, I., Mirzazadeh, R., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.10.017 · Cited by 94
Błasiak, J., Piechota, M. J., Pawłowska, E., Szatkowska, M., Sikora, E., & Kaarniranta, K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5293258 · Cited by 94
Elyahu, Y., & Monsonego, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101231 · Cited by 93
Is exercise a senolytic medicine? A systematic review
Chen, X., Yi, Z., Wong, G. T., Hasan, K. M. M., Kwan, J. S., Ma, A. C., & Chang, R. C. (2021) · Aging Cell · doi:10.1111/acel.13294 · Cited by 88
Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
Masaldan, S., Clatworthy, S. A. S., Gamell, C., Smith, Z. M., Francis, P. S., Denoyer, D., Meggyesy, P. M., Fontaine, S. L., & Cater, M. A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.007 · Cited by 92
MicroRNA‐570 is a novel regulator of cellular senescence and inflammaging
Baker, J. R., Vuppusetty, C., Colley, T., Hassibi, S., Fenwick, P. S., Donnelly, L., Ito, K., & Barnes, P. J. (2018) · The FASEB Journal · doi:10.1096/fj.201800965r · Cited by 93
Pun, F. W., Leung, G. H. D., Leung, H.-W., Liu, B. H. M., Long, X., Ozerov, I. V., Wang, J., Ren, F., Aliper, A. M., Izumchenko, E., et al. (2022) · Aging · doi:10.18632/aging.203960 · Cited by 86
Eukaryotic Cell Size Control and Its Relation to Biosynthesis and Senescence
Xie, S., Swaffer, M. P., & Skotheim, J. M. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120219-040142 · Cited by 93
Zhang, F., Guo, J., Yu, S., Zheng, Y., Duan, M., Zhao, L., Wang, Y., Yang, Z., & Jiang, X. (2024) · 癌症：英文版 · doi:10.1002/cac2.12591 · Cited by 100
Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics
Peng, M., Li, N., Wang, H., Li, Y., Liu, H., Luo, Y., Lang, B., Zhang, W., Li, S., Tian, L., et al. (2025) · MedComm · doi:10.1002/mco2.70304 · Cited by 98
Endothelium-mediated contributions to fibrosis
Sun, X., Nkennor, B., Mastikhina, O., Soon, K., & Nunes, S. S. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.10.015 · Cited by 93
Progress in the study of molecular mechanisms of intervertebral disc degeneration
Xia, Q., Zhao, Y., Dong, H., Mao, Q., Zhu, L., Xia, J., Weng, Z., Liao, W., Hu, Z., Yi, J., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116593 · Cited by 87
JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells
Wu, W., Fu, J., Gu, Y., Yu, W., Ma, P., & Wu, J. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0518 · Cited by 88
Sex/gender-related differences in inflammaging
Olivieri, F., Marchegiani, F., Matacchione, G., Giuliani, A., Ramini, D., Fazioli, F., Sabbatinelli, J., & Bonafè, M. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111792 · Cited by 89
Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases
Yang, B., Lin, Y., Huang, Y., Shen, Y.-Q., & Chen, Q. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103032 · Cited by 94
Non-cell autonomous effects of the senescence-associated secretory phenotype in cancer therapy.
Saleh, T., Tyutynuk-Massey, L., Cudjoe, E. K., Idowu, M. O., Landry, J. W., & Gewirtz, D. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00164 · Cited by 85
Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells
Hansel, C., Jendrossek, V., & Klein, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093279 · Cited by 89
Type I interferons and related pathways in cell senescence
Frisch, S. M., & MacFawn, I. (2020) · Aging Cell · doi:10.1111/acel.13234 · Cited by 89
β cell aging and age-related diabetes
Zhu, M., Liu, X., Liu, W., Lu, Y., Cheng, J., & Chen, Y. (2021) · Aging · doi:10.18632/aging.202593 · Cited by 96
Gan, L., Liu, D., Liu, J., Chen, E., Chen, C., Liu, L., Hu, H., Guan, X., Ma, W., Zhang, Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00625-0 · Cited by 87
Klopack, E. T., Crimmins, E. M., Cole, S. W., Seeman, T. E., & Carroll, J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202780119 · Cited by 87
Hussong, S. A., Banh, A. Q., Skike, C. E. V., Dorigatti, A. O., Hernandez, S. F., Hart, M. J., Ferrán, B., Makhlouf, H., Gaczynska, M. E., Osmulski, P. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37840-y · Cited by 85
Zhang, H., Xu, J., Long, Y., Maimaitijiang, A., Su, Z., Li, W., & Li, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312928 · Cited by 97
Exosome-based immunomodulation during aging: A nano-perspective on inflamm-aging
Prattichizzo, F., Micolucci, L., Cricca, M., Carolis, S. D., Mensa’, E., Ceriello, A., Procopio, A. D., Bonafè, M., & Olivieri, F. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.02.008 · Cited by 86
Clayton, Z. S., Rossman, M. J., Mahoney, S. A., Venkatasubramanian, R., Maurer, G. S., Hutton, D. A., VanDongen, N. S., Greenberg, N. T., Longtine, A. G., Ludwig, K. R., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21392 · Cited by 84
“11,12 As such, cellular senescence may contribute to vascular oxidative stress, reduced NO bioavailability, adverse changes to the aortic ECM, and vascular dysfunction with aging.”
BackgroundTrias, E., Beilby, P. R., Kovacs, M., Ibarburu, S., Varela, V., Barreto-Núñez, R., Bradford, S. C., Beckman, J. S., & Barbeito, L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00042 · Cited by 85
Senescence-Associated MicroRNAs
Munk, R. B., Panda, A. C., Grammatikakis, I., Gorospe, M., & Abdelmohsen, K. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.03.008 · Cited by 90
Influence of the Mediterranean Diet on Healthy Aging
Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 94
Integrated Cascade Nanozymes with Antisenescence Activities for Atherosclerosis Therapy
Liu, W., Zhang, Y., Wei, G., Zhang, M., Li, T., Liu, Q., Zhou, Z., Du, Y., & Wei, H. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202304465 · Cited by 86
Current senolytics: Mode of action, efficacy and limitations, and their future
Rad, A. N., & Grillari, J. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111888 · Cited by 87
Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells
Parikh, P., Britt, R. D., Manlove, L. J., Wicher, S. A., Roesler, A. M., Ravix, J., Teske, J. J., Thompson, M. A., Sieck, G. C., Kirkland, J. L., et al. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0176oc · Cited by 87
Chang-Panesso, M. (2021) · Pediatric Nephrology · doi:10.1007/s00467-020-04849-0 · Cited by 97
Queen, N. J., Hassan, Q. N., & Cao, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00605 · Cited by 86
Byun, H., Lee, Y., Kim, J., & Yoon, G. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.11.122 · Cited by 81
Sanborn, M. A., Wang, X., Gao, S., Dai, Y., & Rehman, J. (2025) · Nature Communications · doi:10.1038/s41467-025-57047-7 · Cited by 82
“In total, we derived 72 mouseand 64 human putative CS cell-type signatures (Supplementary Data 4, 5).”
InfluentialVázquez-Villaseñor, I., Garwood, C. J., Heath, P. R., Simpson, J. E., Ince, P. G., & Wharton, S. B. (2019) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12559 · Cited by 82
Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential
He, Y., Xie, W., Li, H., Jin, H., Zhang, Y., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.793088 · Cited by 84
Frailty biomarkers under the perspective of geroscience: A narrative review
Gonçalves, R. S. D. S. A., Maciel, Á. C. C., Rolland, Y., Vellas, B. J., & Barreto, P. D. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101737 · Cited by 89
Choubey, D., & Panchanathan, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.002 · Cited by 83
Is DNA damage indispensable for stress-induced senescence?
Bielak-Żmijewska, A., Mosieniak, G., & Sikora, E. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.004 · Cited by 86
Nicotine in Senescence and Atherosclerosis
Centner, A. M., Bhide, P. G., & Salazar, G. (2020) · Cells · doi:10.3390/cells9041035 · Cited by 86
Mühleder, S., Fernández-Chacón, M., García-Gónzalez, I., & Benedito, R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03664-y · Cited by 84
Duan, M., Xu, Y., Li, Y., Feng, H., & Chen, Y. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03101-y · Cited by 85
Roy, B. (2025) · Medical Sciences · doi:10.3390/medsci13030087 · Cited by 103
Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects
Fransen, M., & Lismont, C. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7515 · Cited by 87
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1
Cohen, C., Le Goff, O., Soysouvanh, F., Vasseur, F., Tanou, M., Nguyen, C., Amrouche, L., Le Guen, J., Saltel‐Fulero, O., Meunier, T., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114146 · Cited by 79
Self-citationHypothalamic inflammation in metabolic disorders and aging
Bhusal, A., Rahman, M. H., & Suk, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04019-x · Cited by 87
Varela-Eirín, M., Carpintero-Fernández, P., Guitián‐Caamaño, A., Varela-Vázquez, A., García-Yuste, A., Sánchez‐Temprano, A., Bravo, S. B., Cabanas, J. Y., Fonseca, E., Largo, R., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05089-w · Cited by 87
Aquino‐Martinez, R., Eckhardt, B. A., Rowsey, J. L., Fraser, D. G., Khosla, S., Farr, J. N., & Monroe, D. G. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0529 · Cited by 78
Mitochondrial quality control in AMD: does mitophagy play a pivotal role?
Hyttinen, J. M. T., Viiri, J., Kaarniranta, K., & Błasiak, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2843-7 · Cited by 82
Salerno, N., Marino, F., Scalise, M., Salerno, L., Molinaro, C., Filardo, A., Chiefalo, A., Panuccio, G., Angelis, A. D., Urbanek, K., et al. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111740 · Cited by 83
Cellular senescence and kidney aging
Rex, N., Melk, A., & Schmitt, R. (2023) · Clinical Science · doi:10.1042/cs20230140 · Cited by 89
Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
Liu, X., Wang, Y., Zhang, X., Gao, Z., Zhang, S., Shi, P., Zhang, X., Song, L., Hendrickson, H., Zhou, D., et al. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.06.013 · Cited by 77
Population aging and trends of pulmonary tuberculosis incidence in the elderly
Li, S.-J., Li, Y.-F., Song, W.-M., Zhang, Q.-Y., Liu, S.-Q., Xu, T., An, Q.-Q., Liu, J., & Li, H. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-05994-z · Cited by 80
Immune Aging and Immunotherapy in Cancer
Kaiser, M., Semeraro, M. D., Herrmann, M., Absenger, G., Gerger, A., & Renner, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137016 · Cited by 79
Ting, K. K., Coleman, P. R., Kim, H. J., Zhao, Y., Mulangala, J., Cheng, N. C., Li, W., Gunatilake, D., Johnstone, D. M., Loo, L., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00927-x · Cited by 81
DNA damage, metabolism and aging in pro-inflammatory T cells
Li, Y., Goronzy, J. J., & Weyand, C. M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.027 · Cited by 80
Ogata, Y., Yamada, T., Hasegawa, S., Sanada, A., Iwata, Y., Arima, M., Nakata, S., Sugiura, K., & Akamatsu, H. (2020) · Experimental Dermatology · doi:10.1111/exd.14205 · Cited by 84
Severe COVID-19 Lung Infection in Older People and Periodontitis
Aquino-Martínez, R., & Vigueras, S. H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020279 · Cited by 79
Targeting metabolism in cellular senescence, a role for intervention
Nacarelli, T., & Sell, C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.049 · Cited by 79
Li, Z., Jiao, Y., Fan, E. K., Scott, M. J., Li, Y., Li, S., Billiar, T. R., Wilson, M. A., Shi, X., & Fan, J. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700140 · Cited by 78
Senescent cells as promising targets to tackle age-related diseases
Prašnikar, E., Borišek, J., & Perdih, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101251 · Cited by 78
Evaluating causality of cellular senescence in non-alcoholic fatty liver disease
Meijnikman, A. S., Herrema, H., Scheithauer, T. P. M., Kroon, J., Nieuwdorp, M., & Groen, A. K. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100301 · Cited by 81
Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis
Zhang, X., He, S., Liang, X., Li, W., Li, T.-F., & Li, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.728100 · Cited by 78
Microbiota-immune-brain interactions: A lifespan perspective
Ratsika, A., Cruz-Pereira, J. S., Lynch, C. M. K., Clarke, G. A., & Cryan, J. F. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102652 · Cited by 83
Flores, A., Gerónimo‐Olvera, C., Girardi, K. D. C. D. V., Ñecuñir, D., Patel, S. K., Bons, J., Wright, M. C., Geschwind, D. H., Höke, A., Gomez-Sanchez, J. A., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317907 · Cited by 80
Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?
Abbadie, C., Pluquet, O., & Pourtier, A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2587-9 · Cited by 77
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, D., Martins, I., Cristóvão, A. M., Dias, A. F., Neves-Silva, D., Pereira, T., Chapela, D., Farinho, A., Jacinto, A., & Saúde, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109334 · Cited by 74
Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
Rescigno, T., Micolucci, L., Tecce, M. F., & Capasso, A. (2017) · Molecules · doi:10.3390/molecules22010105 · Cited by 75
Jiang, M., Wang, H., Liu, Z., Lin, L., Wang, L., Xie, M., Li, D., Zhang, J., & Zhang, R. (2020) · The FASEB Journal · doi:10.1096/fj.202000734r · Cited by 74
Prattichizzo, F., de Candia, P., & Ceriello, A. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154799 · Cited by 80
NF-κB, a culprit of both inflamm-ageing and declining immunity?
Songkiatisak, P., Rahman, S. M. T., Aqdas, M., & Sung, M. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00277-w · Cited by 81
Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration
Xu, J., Shao, T., Lou, J., Zhang, J., & Xia, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1172920 · Cited by 77
Aging conundrum: A perspective for ovarian aging
Wu, J., Liu, Y., Song, Y., Wang, L., Ai, J., & Li, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.952471 · Cited by 73
YAP1‐LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis
He, C., Lv, X., Huang, C., Hua, G., Ma, B., Chen, X., Angeletti, P. C., Dong, J., Zhou, J. R., Wang, Z., et al. (2019) · EMBO Reports · doi:10.15252/embr.201744948 · Cited by 72
Hughes, M., McGettrick, H. M., & Sapey, E. (2020) · European Respiratory Review · doi:10.1183/16000617.0102-2019 · Cited by 77
The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets
Rossi, M., & Abdelmohsen, K. (2021) · Cells · doi:10.3390/cells10071740 · Cited by 71
Kim, M., Seol, J., Sato, T., Fukamizu, Y., Sakurai, T., & Okura, T. (2022) · Nutrients · doi:10.3390/nu14040755 · Cited by 77
Hallmarks and mechanisms of cellular senescence in aging and disease
Ajoolabady, A., Praticò, D., Bahijri, S., Eldakhakhny, B. M., Tuomilehto, J. O., Wu, F., & Ren, J. T. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02655-x · Cited by 87
SirT3 and p53 Deacetylation in Aging and Cancer
Chen, J., Wang, A., & Chen, Q. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25669 · Cited by 73
Yu, S., Wang, X., Geng, P., Tang, X.-D., Xiang, L., Lu, X., Li, J., Ruan, Z., Chen, J., Xie, G., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12405 · Cited by 72
The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma
Bullone, M., & Lavoie, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122612 · Cited by 74
Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation
Zhang, P., Wang, Q., Nie, L., Zhou, X., Zhou, X., Zhao, P., Ji, N., Liang, X., Ding, Y., Yuan, Q., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010648 · Cited by 75
Malavolta, M., Giacconi, R., Brunetti, D., Provinciali, M., & Maggi, F. (2020) · Cells · doi:10.3390/cells9040909 · Cited by 72
Noninvasive NIR Imaging of Senescence via In Situ Labeling
Liu, J., Ma, X., Cui, C., Chen, Z., Wang, Y., Deenik, P. R., & Cui, L. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01313 · Cited by 77
Rosenberg, N., Van Haele, M., Lanton, T., Brashi, N., Bromberg, Z., Adler, H., Giladi, H., Peled, A., Goldenberg, D. S., Axelrod, J. H., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.07.029 · Cited by 72
Plant-derived nanovesicles: harnessing nature's power for tissue protection and repair
Chen, X., Xing, X., Lin, S., Huang, L., He, L., Zou, Y., Zhang, X., Su, B.-H., Lu, Y., & Zheng, D. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02193-7 · Cited by 72
Therapeutic Potential of Senolytics in Cardiovascular Disease
Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07075-w · Cited by 69
Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth
Li, Y., Zhao, H., Huang, X., Tang, J., Zhang, S., Li, Y., Liu, X., He, L., Ju, Z., Lui, K. O., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0050-6 · Cited by 71
Endothelial Senescence: A New Age in Pulmonary Hypertension
Culley, M. K., & Chan, S. Y. (2022) · Circulation Research · doi:10.1161/circresaha.121.319815 · Cited by 71
Pharma-Nutritional Properties of Olive Oil Phenols. Transfer of New Findings to Human Nutrition
Crespo, M. C., Tomé‐Carneiro, J., Dávalos, A., & Visioli, F. (2018) · Foods · doi:10.3390/foods7060090 · Cited by 72
SETD1A protects from senescence through regulation of the mitotic gene expression program
Tajima, K., Matsuda, S., Yae, T., Drapkin, B. J., Morris, R. T., Boukhali, M., Niederhoffer, K., Comaills, V., Dubash, T. D., Nieman, L. T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10786-w · Cited by 73
Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease
Lynch, S. M., Guo, G., Gibson, D. S., Bjourson, A. J., & Singh, T. (2021) · Cells · doi:10.3390/cells10123367 · Cited by 70
p53: From Fundamental Biology to Clinical Applications in Cancer
Capuozzo, M., Santorsola, M., Bocchetti, M., Perri, F., Cascella, M., Granata, V., Celotto, V., Gualillo, O., Cossu, A. M., Nasti, G., et al. (2022) · Biology · doi:10.3390/biology11091325 · Cited by 74
Yaakov, T. B., Wasserman, T., Aknin, E., & Savir, Y. (2023) · eLife · doi:10.7554/elife.74915 · Cited by 69
Targeting senescent cells with NKG2D-CAR T cells
Deng, Y., Kumar, A., Xie, K., Schaaf, K., Scifo, E., Morsy, S., Li, T., Ehninger, A., Bano, D., & Ehninger, D. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01976-7 · Cited by 75
Drew, W., Wilson, D. V., & Sapey, E. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.020 · Cited by 73
Metadata
- Authors
- Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M.
- Affiliations
- Mayo Clinic (US)
- Venue
- Nature Medicine
- Published
- 2015-12
- Volume
- 21
- Issue
- 12
- Pages
- 1424-1435
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC4748967
- OpenAlex
- W2193792657
- Cited by
- 2,363
- References
- 170
- Citations by year
- 2026: 257 · 2025: 278 · 2024: 275 · 2023: 278 · 2022: 259 · 2021: 266 · 2020: 246 · 2019: 191 · 2018: 153 · 2017: 106 · 2016: 51 · 2015: 1
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute on Aging (AG41122-01P2, P01AG041122, R37AG013925)
- National Cancer Institute (R01CA166347, R01CA096985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, aging, age-related diseases, senescent cells, senescence induction, senolytics, anti-aging therapy, paracrine signaling, autocrine signaling, proliferative arrest
- MeSH terms
- Aging, Animals, Disease, Health, Humans, Longevity, Signal Transduction, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
