Validating Stat3 in cancer therapy

STATs: transcriptional control and biological impact

Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201

Stat3 as an Oncogene

Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790

Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K., Shapiro, D. N., Saltman, D. L., & Look, A. T. (1994) · Science · doi:10.1126/science.8122112 · Cited by 2,428

The STATs of cancer — new molecular targets come of age

Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278

Transcription factors as targets for cancer therapy

Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

Yoshikawa, H., Matsubara, K., Qian, G.-S., Jackson, P. E., Groopman, J. D., Manning, J. E., Harris, C. C., & Herman, J. G. (2001) · Nature Genetics · doi:10.1038/ng0501-29 · Cited by 724

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

Song, H., Wang, R., Wang, S., & Lin, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409894102 · Cited by 504

Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

Chiarle, R., Simmons, W. J., Cai, H., Dhall, G., Zamò, A., Raz, R., Karras, J. G., Levy, D. E., & Inghirami, G. (2005) · Nature Medicine · doi:10.1038/nm1249 · Cited by 441

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

He, B., You, L., Uematsu, K., Zang, K., Xu, Z., Lee, A. Y., Costello, J. F., McCormick, F., & Jablons, D. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232790100 · Cited by 380

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

Chan, K. S., Sano, S., Kiguchi, K., Anders, J., Komazawa, N., Takeda, J., & DiGiovanni, J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21032 · Cited by 355

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

Schust, J., Sperl, B., Hollis, A., Mayer, T. U., & Berg, T. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.018 · Cited by 1,105

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

Bollrath, J., Phesse, T. J., von Burstin, V. A., Putoczki, T., Bennecke, M., Bateman, T., Nebelsiek, T., Lundgren-May, T., Canli, Ö., Schwitalla, S., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.002 · Cited by 946

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Siddiquee, K., Zhang, S., Guida, W. C., Blaskovich, M. A., Greedy, B. M., Lawrence, H. R., Yip, M. L. R., Jove, R., McLaughlin, M. M., Lawrence, N. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609757104 · Cited by 741

JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

Salas, A., Hernández-Rocha, C., Duijvestein, M., Faubion, W. A., McGovern, D. P. B., Vermeire, S., Vetrano, S., & Casteele, N. V. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0273-0 · Cited by 658

STAT3 as a target for inducing apoptosis in solid and hematological tumors

Siddiquee, K., & Turkson, J. (2008) · Cell Research · doi:10.1038/cr.2008.18 · Cited by 496

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

Sherry, M. M., Reeves, A., Wu, J. K., & Cochran, B. H. (2009) · Stem Cells · doi:10.1002/stem.185 · Cited by 478

Therapeutic modulators of STAT signalling for human diseases

Miklóssy, G., Hilliard, T. S., & Turkson, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4088 · Cited by 418

Targeting STAT3 in cancer: how successful are we?

Yue, P.-B., & Turkson, J. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780802565791 · Cited by 425

Dysregulated molecular networks in head and neck carcinogenesis

Molinolo, A., Amornphimoltham, P., SQUARIZE, C. H., CASTILHO, R. M., Patel, V., & Gutkind, J. S. (2008) · Oral Oncology · doi:10.1016/j.oraloncology.2008.07.011 · Cited by 387

Signaling Pathways in Cancer and Embryonic Stem Cells

Dreesen, O., & Brivanlou, A. H. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-0004-8 · Cited by 362

The role of STAT3 in leading the crosstalk between human cancers and the immune system

Wang, Y., Shen, Y., Wang, S., Shen, Q., & Zhou, X. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.12.003 · Cited by 343

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

Sen, M., Thomas, S. M., Kim, S., Yeh, J. I., Ferris, R. L., Johnson, J. T., Duvvuri, U., Lee, J., Sahu, N., Joyce, S., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0191 · Cited by 313

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas

Ding, B. B., Yu, J., Yu, R. Y.-L., Mendez, L., Shaknovich, R., Zhang, Y., Cattoretti, G., & Ye, B. H. (2007) · Blood · doi:10.1182/blood-2007-04-087734 · Cited by 301

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

Kotha, A., Sekharam, M., Cilenti, L., Siddiquee, K., Khaled, A. R., Zervos, A. S., Carter, B., Turkson, J., & Jove, R. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0268 · Cited by 289

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

Cheng, J.-T., Deng, Y.-N., Yi, H.-M., Wang, G.-S., Fu, B.-S., Chen, W., Liu, W., Tai, Y., Peng, Y.-W., & Zhang, Q. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.7 · Cited by 271

Targeting Protein–Protein Interactions for Therapeutic Intervention: A Challenge for the Future

Zinzalla, G., & Thurston, D. E. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.12 · Cited by 266

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

Jarnicki, A., Putoczki, T. L., & Ernst, M. (2010) · Cell Division · doi:10.1186/1747-1028-5-14 · Cited by 246

JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia

Satriotomo, I., Bowen, K. K., & Vemuganti, R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04051.x · Cited by 227

Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer Therapy

Germain, D., & Frank, D. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2491 · Cited by 221

Luteolin Promotes Degradation in Signal Transducer and Activator of Transcription 3 in Human Hepatoma Cells: An Implication for the Antitumor Potential of Flavonoids

Selvendiran, K., Koga, H., Ueno, T., Yoshida, T., Maeyama, M., Torimura, T., Yano, H., Kojiro, M., & Sata, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4062 · Cited by 217

STAT3 activation

Rébé, C., Végran, F., Berger, H., & Ghiringhelli, F. (2013) · JAK-STAT · doi:10.4161/jkst.23010 · Cited by 222

Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes

Winter, C., Kristiansen, G., Kersting, S., Roy, J., Aust, D. E., Knösel, T., Rümmele, P., Jahnke, B., Hentrich, V., Rückert, F., et al. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002511 · Cited by 208

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

Zhang, X., Guo, A., Yu, J., Possemato, A. P., Chen, Y., Zheng, W., Polakiewicz, R. D., Kinzler, K. W., Vogelstein, B., Velculescu, V. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611665104 · Cited by 214

Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage

YI, J., PARK, S., KAPADIA, R., & VEMUGANTI, R. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.019 · Cited by 206

The MicroRNA let-7a Modulates Interleukin-6-dependent STAT-3 Survival Signaling in Malignant Human Cholangiocytes

Meng, F., Henson, R., Wehbe–Janek, H., Smith, H., Ueno, Y., & Patel, T. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607712200 · Cited by 201

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

Hazan‐Halevy, I., Harris, D., Liu, Z., Liu, J., Li, P., Chen, X., Shanker, S., Ferrajoli, A., Keating, M. J., & Estrov, Z. E. (2010) · Blood · doi:10.1182/blood-2009-10-230060 · Cited by 209

chinmo Is a Functional Effector of the JAK/STAT Pathway that Regulates Eye Development, Tumor Formation, and Stem Cell Self-Renewal in Drosophila

Flaherty, M. S., Salis, P., Evans, C. J., Ekas, L. A., Marouf, A., Zavadil, J., Banerjee, U. K., & Bach, E. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.006 · Cited by 189

STAT3 and apoptosis challenges in cancer

Fathi, N., Rashidi, G., Khodadadi, A., Shahi, S., & Sharifi, S. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.05.121 · Cited by 191

Molecular targets of isothiocyanates in cancer: Recent advances

Gupta, P., Kim, B., Kim, S., & Srivastava, S. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300684 · Cited by 191

An Oxazole-Based Small-Molecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects

Siddiquee, K., Gunning, P. T., Glenn, M. P., Katt, W. P., Zhang, S., Schrock, C. E., Sebti, S. M., Jove, R., Hamilton, A. D., & Turkson, J. (2007) · ACS Chemical Biology · doi:10.1021/cb7001973 · Cited by 188

Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells

Liu, X., Huang, J., Chen, T., Wang, Y., Xin, S., Li, J., Pei, G., & Kang, J. (2008) · Cell Research · doi:10.1038/cr.2008.309 · Cited by 188

A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

Zhang, X., Yue, P., Fletcher, S., Zhao, W., Gunning, P. T., & Turkson, J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.01.001 · Cited by 179

Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma

Han, Y., Amin, H. M., Franko, B., Frantz, C., Shi, X., & Lai, R. L. (2006) · Blood · doi:10.1182/blood-2006-04-017434 · Cited by 179

Epigallocatechin gallate and mitochondria—A story of life and death

de Oliveira, M. R., Nabavi, S. F., Daglia, M., Rastrelli, L., & Nabavi, S. M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.027 · Cited by 174

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

Zhang, Q., Wang, H. Y., Woetmann, A., Raghunath, P. N., Ødum, N., & Wasik, M. A. (2006) · Blood · doi:10.1182/blood-2005-08-007377 · Cited by 178

Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation

Braun, D. A., Fribourg, M., & Sealfon, S. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386573 · Cited by 168

Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML

Zhou, J., Bi, C., Janakakumara, J. V., Liu, S.-C., Chng, W. J., Tay, K.-G., Poon, L.-F., Xie, Z., Palaniyandi, S., Yu, H., et al. (2009) · Blood · doi:10.1182/blood-2008-05-156422 · Cited by 172

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Burgess, J. K., Mutsaers, S. E., Prêle, C. M., Schuliga, M. J., Grainge, C., & Knight, D. A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00037.2018 · Cited by 171

Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer

Kowshik, J., Baba, A. B., Giri, H., Reddy, G. D., Dixit, M., & Nagini, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109114 · Cited by 165

The function of Stat3 in tumor cells and their microenvironment

Groner, B., Lucks, P., & Borghouts, C. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.06.005 · Cited by 160

Cancer chemoprevention: scientific promise, clinical uncertainty

Sporn, M. B., & Liby, K. T. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0319 · Cited by 157

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

Herrmann, A., Priceman, S. J., Kujawski, M., Xin, H., Cherryholmes, G. A., Zhang, W., Zhang, C., Lahtz, C., Kowolik, C. M., Forman, S. J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73174 · Cited by 156

The Role of STAT-3 in the Induction of Apoptosis in Pancreatic Cancer Cells by Benzyl Isothiocyanate

Sahu, R. P., & Srivastava, S. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn470 · Cited by 150

Identification of a New Series of STAT3 Inhibitors by Virtual Screening

Matsuno, K., Masuda, Y., Uehara, Y., Satō, H., Muroya, A., Takahashi, O., Yokotagawa, T., Furuya, T., Okawara, T., Otsuka, M., et al. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml1000273 · Cited by 149

Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells

Behera, R., Kumar, V., Lohite, K., Karnik, S., & Kundu, G. C. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp289 · Cited by 146

IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells

Ding, B. B., Bi, E., Chen, H., Yu, J. J., & Ye, B. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201678 · Cited by 144

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

Timofeeva, O. A., Tarasova, N. I., Zhang, X., Chasovskikh, S., Cheema, A. K., Wang, H., Brown, M. L., & Dritschilo, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211805110 · Cited by 142

Cucurbitacins : A Promising Target for Cancer Therapy

Alghasham, A. (2013) · International Journal of Health Sciences · doi:10.12816/0006025 · Cited by 141

Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells

Yue, P., Zhang, X., Paladino, D., Sengupta, B., Ahmad, S., Holloway, R. W., Ingersoll, S. B., & Turkson, J. (2011) · Oncogene · doi:10.1038/onc.2011.409 · Cited by 137

Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy

Thuya, W. L., Cao, Y., Ho, P. C., Wong, A. L., Wang, L., Zhou, J., Nicot, C., & Goh, B. C. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.01.003 · Cited by 154

Paradigm shifts in the cell biology of STAT signaling

Sehgal, P. B. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.003 · Cited by 135

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

Xu, X., Kasembeli, M. M., Jiang, X., Tweardy, B. J., & Tweardy, D. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004783 · Cited by 135

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

Liu, L., Leung, K., Chan, D. S.-H., Wang, Y.-T., Ma, D., & Leung, C.-H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.250 · Cited by 123

Selective Inhibition of ErbB2-Overexpressing Breast Cancer In vivo by a Novel TAT-Based ErbB2-Targeting Signal Transducers and Activators of Transcription 3–Blocking Peptide

Tan, M., Lan, K., Yao, J., Lu, C., Sun, M., Neal, C. L., Lü, J., & Yu, D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2747 · Cited by 123

Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP

Huang, X., Meng, B., Iqbal, J., Ding, B. B., Perry, A. M., Cao, W., Smith, L. M., Bi, C., Jiang, C., Greiner, T. C., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.6004 · Cited by 126

Discovery of O-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents

Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q., & Zhou, J. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml3003082 · Cited by 121

Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target

Saini, U., Naidu, S. I., ElNaggar, A. C., Bid, H. K., Wallbillich, J. J., Bixel, K. L., Bolyard, C. M., Suarez, A. A., Kaur, B., Kuppusamy, P., et al. (2016) · Oncogene · doi:10.1038/onc.2016.197 · Cited by 119

The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells

Liby, K. T., Voong, N., Williams, C. R., Risingsong, R., Royce, D. B., Honda, T., Gribble, G. W., Sporn, M. B., & Letterio, J. J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0215 · Cited by 116

Stat3-Targeted Therapies Overcome the Acquired Resistance to Vemurafenib in Melanomas

Liu, F., Cao, J., Wu, J., Sullivan, K., Shen, J. L., Ryu, B., Xu, Z., Wei, W., & Cui, R. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.32 · Cited by 126

Sorafenib inhibits signal transducer and activator of transcription‐3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2†

Blechacz, B. R. A., Smoot, R. L., Bronk, S. F., Werneburg, N. W., Sirica, A. E., & Gores, G. J. (2009) · Hepatology · doi:10.1002/hep.23214 · Cited by 116

Inhibition of transcription factors with small organic molecules

Berg, T. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2008.07.023 · Cited by 120

Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer

Li, Q., Zhang, D., Chen, X., He, L., Li, T., Xu, X., & Li, M. (2015) · Scientific Reports · doi:10.1038/srep16082 · Cited by 114

The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine

Alshamsan, A., Hamdy, S. I., Samuel, J., El‐Kadi, A. O. S., Lavasanifar, A., & Uludağ, H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.003 · Cited by 114

STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation

Laßmann, S., Schuster, I., Walch, A. K., Göbel, H., Jütting, U., Makowiec, F., Hopt, U. T., & Werner, M. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.035113 · Cited by 114

Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR−/HER2+breast cancersPreprint

Barrueco, R. R., Yu, J., Saucedo-Cuevas, L. P., Oliván, M., Llobet‐Navàs, D., Putcha, P., Castro, V., Murga-Penas, E., Collazo-Lorduy, A., Castillo-Martín, M., et al. (2015) · Genes & Development · doi:10.1101/gad.262642.115 · Cited by 111

Identification of novel direct Stat3 target genes for control of growth and differentiation

Snyder, M., Huang, X.-Y., & Zhang, J. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706976200 · Cited by 108

Nonclassical Biological Activities of Quinolone Derivatives

Daneshtalab, M., & Ahmed, A. A. (2011) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3302n · Cited by 109

Dynamics and non-canonical aspects of JAK/STAT signalling

Mohr, A., Chatain, N., Domoszlai, T., Rinis, N., Sommerauer, M., Vogt, M., & Müller‐Newen, G. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.09.005 · Cited by 113

Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein

Fletcher, S., Turkson, J., & Gunning, P. T. (2008) · ChemMedChem · doi:10.1002/cmdc.200800123 · Cited by 105

Recent development of transition metal complexes with in vivo antitumor activity

Liang, J., Zhong, H., Yang, G., Vellaisamy, K., Ma, D., & Leung, C. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.06.002 · Cited by 101

Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway

Du, W., Hong, J., Wang, Y., Zhang, Y., Wang, P., Su, W., Lin, Y., Lu, R., Zou, W., Xiong, H., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01483.x · Cited by 101

The Drosophila cyst stem cell lineage

Zoller, R., & Schulz, C. (2012) · Spermatogenesis · doi:10.4161/spmg.21380 · Cited by 100

Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer

Zhang, Z. H., Li, M. Y., Wang, Z., Zuo, H. X., Wang, J. Y., Xing, Y., Jin, C. H., Xu, G., Piao, L. X., Piao, H., et al. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153172 · Cited by 100

Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification

Meeusen, B., & Janssens, V. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.10.002 · Cited by 96

STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17

Dai, B., Meng, J., Peyton, M., Girard, L., Bornmann, W. G., Ji, L., Minna, J. D., Fang, B., & Roth, J. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3647 · Cited by 94

Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides

Weerasinghe, P., Garcia, G., Zhu, Q., Yuan, P., Feng, L., Mao, L., & Jing, N. (2007) · International Journal of Oncology · doi:10.3892/ijo.31.1.129 · Cited by 95

Nucleocytoplasmic shuttling of persistently activated STAT3

Herrmann, A., Vogt, M., Mönnigmann, M., Clahsen, T., Sommer, U., Haan, S., Poli, V., Heinrich, P. C., & Müller-Newen, G. (2007) · Journal of Cell Science · doi:10.1242/jcs.03482 · Cited by 94

Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells

Zhang, G., Tsang, C. M., Deng, W., Yip, Y. L., Lui, V. W. Y., Wong, S. C. C., Cheung, A. L. M., Hau, P. M., Zeng, M., Lung, M. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062284 · Cited by 93

Fragment-based drug design and identification of HJC0123 , a novel orally bioavailable STAT3 inhibitor for cancer therapy

Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q., & Zhou, J. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.01.023 · Cited by 94

STAT3 Polymorphism Predicts Interferon-Alfa Response in Patients With Metastatic Renal Cell Carcinoma

Ito, N., Eto, M., Nakamura, E., Takahashi, A., Tsukamoto, T., Toma, H., Nakazawa, H., Hirao, Y., Uemura, H., Kagawa, S., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.8897 · Cited by 91

JAK/STAT pathway dysregulation in tumors: A Drosophila perspective

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Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors

Molavi, O., Ma, Z., Mahmud, A., Alshamsan, A., Samuel, J., Lai, R. L., Kwon, G. S., & Lavasanifar, A. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.032 · Cited by 91

Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF‐κB signaling pathways

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Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer

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Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities

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Targeting JAK1/STAT3 Signaling Suppresses Tumor Progression and Metastasis in a Peritoneal Model of Human Ovarian Cancer

Wen, W. X., Liang, W. P., Wu, J., Kowolik, C. M., Buettner, R., Scuto, A., Hsieh, M.-Y., Hong, H., Brown, C. E., Forman, S. J., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0077 · Cited by 88

Adiponectin deficiency: Role in chronic inflammation induced colon cancer

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Genetic alterations of protein tyrosine phosphatases in human cancers

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MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents

Fan, W., Tang, Z., Yin, L., Morrison, B., Hafez-Khayyata, S., Fu, P., Huang, H., Bagai, R. K., Jiang, S., Kresak, A. M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2668 · Cited by 83

Galiellalactone is a novel therapeutic candidate against hormone‐refractory prostate cancer expressing activated Stat3

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S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation

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Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals

Evans, M. K., Yu, C.-R., Lohani, A., Mahdi, R. M., Liu, X., Trzeciak, A. R., & Egwuagu, C. E. (2006) · Oncogene · doi:10.1038/sj.onc.1209993 · Cited by 82

STAT3: A Potential Drug Target for Tumor and Inflammation

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Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1–Stat3

Wu, C. X., Xu, A., Zhang, C. C., Olson, P., Chen, L., Lee, T. K., Cheung, T. T., Lo, C. M., & Wang, X. Q. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0001 · Cited by 80

Embelin Reduces Colitis-Associated Tumorigenesis through Limiting IL-6/STAT3 Signaling

Dai, Y., Jiao, H., Teng, G., Wang, W., Zhang, R., Wang, Y., Hebbard, L., George, J., & Qiao, L. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0378 · Cited by 78

STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo

Zhou, X., Ren, Y., Liu, A., Han, L., Zhang, K., Li, S., Li, P., Li, P., Kang, C., Wang, X., et al. (2014) · Oncology Reports · doi:10.3892/or.2014.3114 · Cited by 76

α-Mangostin: A Dietary Antioxidant Derived from the Pericarp of Garcinia mangostana L. Inhibits Pancreatic Tumor Growth in Xenograft Mouse Model

Hafeez, B. B., Mustafa, A., Fischer, J. W., Singh, A. K., Zhong, W., Shekhani, M. O., Meske, L. M., Havighurst, T. C., Kim, K., & Verma, A. K. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5212 · Cited by 77

Restoration of shp1 expression by 5-AZA-2′-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma

Han, Y. T., Amin, H. M., Frantz, C. E., Franko, B., Lee, J., Lin, Q., & Lai, R. L. (2006) · Leukemia · doi:10.1038/sj.leu.2404323 · Cited by 74

STAT3 Inhibition in Cancer: A Review of Emerging Therapeutics

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STAT3 transcription factor as target for anti-cancer therapy

Mohassab, A. M., Hassan, H. A., Abdelhamid, D. S., & Abdel‐Aziz, M. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00156-5 · Cited by 57

Targeting transcription factor STAT3 for cancer prevention and therapy

Chai, E. Z. P., Shanmugam, M. K., Arfuso, F., Dharmarajan, A., Wang, C., Kumar, A. P., Samy, R. P., Lim, L. H. K., Wang, L., Goh, B. C., et al. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.10.004 · Cited by 272

Signal transducer and activator of transcription 3 (STAT3)

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REVIEW REVIEW Central Role of STAT3 in Tumors

Stat, P., & Stat, S. L. (2016)