Darnell, James E.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 6,080

STATs and Gene Regulation

Darnell, J. E. (1997) · Science

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 3,979

STATs: transcriptional control and biological impact

Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 3,201

Stat3 as an Oncogene

Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 2,790

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 2,070

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 1,974

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 1,808

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

Sladek, F. M., Zhong, W. M., Lai, E., & Darnell, J. E. (1990) · Genes & Development

Genomics and Chromatin DynamicsLiver physiology and pathology

Cited by 1,027

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., & Yancopoulos, G. D. (1995) · Science

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 979

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

Schindler, C., Shuai, K., Prezioso, V. R., & Darnell, J. E. (1992) · Science

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 899

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Shuai, K., Horvath, C. M., Huang, L. H. T., Qureshi, S. A., Cowburn, D., & Darnell, J. E. (1994) · Cell

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 807

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

Shuai, K., Stark, G. R., Kerr, L. M., & Darnell, J. E. (1993) · Science

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 802

Signal Transduction and the Control of Gene Expression

Brivanlou, A. H., & Darnell, J. E. (2002) · Science

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 699

Stat3 Activation Is Required for Cellular Transformation by v- src

Bromberg, J. F., Horvath, C. M., Besser, D., Lathem, W. W., & Darnell, J. E. (1998) · Molecular and Cellular Biology

Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 614

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E., Stein, R. B., & Rosen, J. (1995) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 415

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.

Müller, M., Laxton, C., Briscoe, J., Schindler, C., Improta, T., Darnell, J. E., Stark, G. R., & Kerr, I. M. (1993) · The EMBO Journal

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 411

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 397

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

Haspel, R. L., Salditt‐Georgieff, M., & Darnell, J. E. (1996) · The EMBO Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 312

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites.

Vinkemeier, U., Cohen, S. L., Moarefi, I., Chait, B. T., Kuriyan, J., & Darnell, J. E. (1996) · The EMBO Journal

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 308

Validating Stat3 in cancer therapy

Darnell, J. E. (2005) · Nature Medicine

Cytokine Signaling Pathways and InteractionsTGF-β signaling in diseases

Cited by 307

Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3

Leslie, K., Lang, C., Devgan, G., Azare, J., Berishaj, M., Gerald, W., Kim, Y. B., Paz, K., Darnell, J. E., Albanese, C., et al. (2006) · Cancer Research

Cytokine Signaling Pathways and InteractionsCancer-related Molecular Pathways

Cited by 285

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

Shen, Y., Devgan, G., Darnell, J. E., & Bromberg, J. F. (2001) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 249

Stat3 Recruitment by Two Distinct Ligand-induced, Tyrosine-phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain

Weber-Nordt, R. M., Riley, J. K., Greenlund, A. C., Moore, K. W., Darnell, J. E., & Schreiber, R. D. (1996) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 218

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1

Haspel, R. L., & Darnell, J. E. (1999) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 203