The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
Open accessAbstract
Development of therapeutic agents for severe acute respiratory syndrome (SARS) viral infection using short interfering RNA (siRNA) inhibitors exemplifies a powerful new means to combat emerging infectious diseases. Potent siRNA inhibitors of SARS coronavirus (SCV) in vitro were further evaluated for efficacy and safety in a rhesus macaque (Macaca mulatta) SARS model using clinically viable delivery while comparing three dosing regimens. Observations of SARS-like symptoms, measurements of SCV RNA presence and lung histopathology and immunohistochemistry consistently showed siRNA-mediated anti-SARS efficacy by either prophylactic or therapeutic regimens. The siRNAs used provided relief from SCV infection–induced fever, diminished SCV viral levels and reduced acute diffuse alveoli damage. The 10–40 mg/kg accumulated dosages of siRNA did not show any sign of siRNA-induced toxicity. These results suggest that a clinical investigation is warranted and illustrate the prospects for siRNA to enable a massive reduction in development time for new targeted therapeutic agents.
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Cites
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Cited by
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Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus
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Self-citationProgress towards in Vivo Use of siRNAs
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Antiviral agents active against influenza A viruses
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Self-citationNonviral methods for siRNA delivery
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Lipid nanoparticles for short interfering RNA delivery
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Metadata
- Authors
- Li, B.-J., Tang, Q., Cheng, D., Qin, C., Xie, F. Y., Wei, Q., Xu, J., Liu, Y., Zheng, B.-J., Woodle, M. C., Zhong, N., & Lu, P. Y.
- Venue
- Nature Medicine
- Published
- 2005-08-21
- Volume
- 11
- Issue
- 9
- Pages
- 944-951
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2006231275
- Cited by
- 433
- References
- 2
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
