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Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

Darrah, Patricia A, Patel, Dipti T, De Luca, Paula M, Lindsay, Ross W B, Davey, Dylan F, Flynn, Barbara J, Hoff, Søren T, Andersen, Peter, Reed, Steven G, Morris, Sheldon L, Roederer, Mario, Seder, Robert A·2007·Nature Medicine

DOI 10.1038/nm1592

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Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes
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“We used Boolean combinations of gated DC subsets in the three cytokine gates (IL-12, IL-6, and TNF-a) as described to uniquely discriminate responding cells based on their cytokine production (25).”
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Authors: Darrah, P. A., Patel, D. T., De Luca, P. M., Lindsay, R. W. B., Davey, D. F., Flynn, B. J., Hoff, S. T., Andersen, P., Reed, S. G., Morris, S. L., Roederer, M., & Seder, R. A.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2007-06-10
Volume: 13
Issue: 7
Pages: 843-850
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/nm1592
OpenAlex: W2066738380
Cited by: 1,378
References: 47
FWCI: 94.76
Type: journal article
Language: en
Open access: closed

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Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

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