The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
Imaging macrophages with nanoparticles
Abstract
Nanomaterials have much to offer, not only in deciphering innate immune cell biology and tracking cells, but also in advancing personalized clinical care by providing diagnostic and prognostic information, quantifying treatment efficacy and designing better therapeutics. This Review presents different types of nanomaterial, their biological properties and their applications for imaging macrophages in human diseases, including cancer, atherosclerosis, myocardial infarction, aortic aneurysm, diabetes and other conditions. We anticipate that future needs will include the development of nanomaterials that are specific for immune cell subsets and can be used as imaging surrogates for nanotherapeutics. New in vivo imaging clinical tools for noninvasive macrophage quantification are thus ultimately expected to become relevant to predicting patients' clinical outcome, defining treatment options and monitoring responses to therapy.
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“These organs typically cope relatively well with high SPION accumulation, which can be explained – at least in part – by the fact that the liver is main storage organ for iron in the body [132].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [132]
In the citing paper
“Macrophage infiltration can be used as a biomarker in several pathological conditions. It can for instance provide information on the stage and progression of cardiovascular disorders, such as atherosclerosis [169, 170].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [169]
In the citing paper
“Approximately 100-fold higher resolution than conventional computed tomography scans showed promise, and this approach is being clinically tested for application in human subjects.152”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [152]
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Rejali, L., Lotfi, M., Pourakbar, P., Masoudiankhouzani, M., Haghighi, A. B., Maleki, K., & Chermehini, N. Y. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10151-6
Cell Selective STING‐Activating Polysaccharide Immunomodulators for Cancer Therapy
Zhu, Q., Miao, J., Ds, X., Mc, Z., Chen, S. H., Wang, J., Chen, W., Guo, J., Xu, L., Ma, S., et al. (2026) · Advanced Materials · doi:10.1002/adma.74178
A Rhodamine-Mannan Fluorescent Probe Targeting M2 Macrophages for Polarization Imaging
Wen, L., Li, Y., Wu, T., Yu, Y., Wu, Y., Wang, Y., & Wang, D. (2026) · Journal of Fluorescence · doi:10.1007/s10895-026-04892-4
Smart Nanotechnology for Precision Immunomodulation
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Feng, J., Huang, Y., He, Y., Deng, C., Jiang, Z., Li, Q., Li, Y., Lan, X., & Xu, Y. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1912847
Tumor-associated macrophages: Ontogeny, plasticity, spatial ecosystems, and therapeutic targeting
Elnaggar, A., & Elnaggar, A. (2026) · Advances in cancer research · doi:10.1016/bs.acr.2026.06.002
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Cardiac nanomedicine for ischemic injury and remodeling: imaging and therapy
Zhang, W., Zeng, X.-L., Himly, M., Li, Y., & Zhang, G. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2742413
Bionanomaterial-Based Diagnostics and Drug Delivery
Poongavanam, S. S., Abdul-Azees, P. A., Chen, J., Dai, Q., Cheng, H., Marinkovic, M., Dean, D. D., Chen, X., & Yeh, C. (2026) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-92-1553-9_4
Wang, T., Liu, C., Yang, H., Li, H., Liu, H., & Jia, F. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c15245
Metadata
- Authors
- Weissleder, R., Nahrendorf, M., & Pittet, M. J.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Weissleder, Ralph
- Venue
- Nature Materials
- Published
- 2014-01-23
- Volume
- 13
- Issue
- 2
- Pages
- 125-138
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2092877053
- Cited by
- 809
- References
- 183
- Citations by year
- 2026: 25 · 2025: 31 · 2024: 36 · 2023: 51 · 2022: 61 · 2021: 67 · 2020: 80 · 2019: 64 · 2018: 90 · 2017: 105 · 2016: 90 · 2015: 79 · 2014: 28
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Keywords
- macrophages, nanomaterials, macrophage targeting, tumor imaging, atherosclerosis, myocardial infarction, aortic aneurysm, diabetes mellitus, inflammation, innate immunity, cell tracking, non-invasive imaging, nanotherapeutics
- MeSH terms
- Humans, Inflammation, Macrophages, Nanoparticles, Cell Tracking
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