Controlled gene expression in primary Lgr5 organoid cultures

Koo, Bon-Kyoung, Stange, Daniel E, Sato, Toshiro, Karthaus, Wouter, Farin, Henner F, Huch, Meritxell, van Es, Johan H, Clevers, Hans·2012·Nature Methods

DOI 10.1038/nmeth.1802

Cited by (322)

Items 101–200 of 322

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Lingling Xian, Dan Georgess, Tait H Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qi-hua Gu, Xiaoyan Zhang, Stefania Senger et al. · 2017 · Nature Communications
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Pramudita Ramadhina Prasetyanti, Cheryl Doreen Zimberlin, Michael L Bots, Louis Vermeulen, Felipe de Sousa e Melo, Jan Paul Medema · 2013 · Molecular Cancer
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Ranga, Adrian, Lutolf, Matthias P · 2012 · Current Opinion in Cell Biology
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Wen-Yi Li, Zhaokun Wu, Weidong Meng, Chao-Ting Zhang, Ming-Zhen Cheng, Yue-Hong Chen, Yini Zou, Ke-Jun Li, S. Lin, Wenjun Xiong et al. · 2022 · Cytokine
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Anthony M. Esposito, Pamela Cheung, Talia H. Swartz, Hongru Li, Tshidi Tsibane, Natasha D. Durham, Christopher F. Basler, Dan P. Felsenfeld, Benjamin K. Chen · 2016 · Virology
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