Reversed graph embedding resolves complex single-cell trajectories
Qiu, Xiaojie, Mao, Qi, Tang, Ying, Wang, Li, Chawla, Raghav, Pliner, Hannah A, Trapnell, Cole·2017·Nature Methods
Cited by (141)
Items 101–141 of 141
- Novel insights from a multiomics dissection of the Hayflick limitChan, Michelle, Yuan, Han, Soifer, Ilya, Maile, Tobias M, Wang, Rebecca Y, Ireland, Andrea, O'Brien, Jonathon J, Goudeau, Jérôme, Chan, Leanne JG, Vijay, Twaritha et al. · 2022 · eLife
- A panoramic view of cell population dynamics in mammalian agingZhang, Zehao, Schaefer, Chloe, Jiang, Weirong, Lu, Ziyu, Lee, Jasper, Sziraki, Andras, Abdulraouf, Abdulraouf, Wick, Brittney, Haeussler, Maximilian, Li, Zhuoyan et al. · 2025 · Science
- Altered cell and RNA isoform diversity in aging Down syndrome brainsPalmer, Carter R., Liu, Christine S., Romanow, William J., Lee, Ming-Hsiang, Chun, Jerold · 2021 · Proceedings of the National Academy of Sciences
- Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infectionKasmani, Moujtaba Y., Zander, Ryan, Chung, H. Kay, Chen, Yao, Khatun, Achia, Damo, Martina, Topchyan, Paytsar, Johnson, Kaitlin E., Levashova, Darya, Burns, Robert et al. · 2023 · Journal of Experimental Medicine
- Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegenerationWelch, Gwyneth M., Boix, Carles A., Schmauch, Eloi, Davila-Velderrain, Jose, Victor, Matheus B., Dileep, Vishnu, Bozzelli, P. Lorenzo, Su, Qiao, Cheng, Jemmie D., Lee, Audrey et al. · 2022 · Science Advances
- Mosaic integration and knowledge transfer of single-cell multimodal data with MIDASHe, Zhen, Hu, Shuofeng, Chen, Yaowen, An, Sijing, Zhou, Jiahao, Liu, Runyan, Shi, Junfeng, Wang, Jing, Dong, Guohua, Shi, Jinhui et al. · 2024 · Nature Biotechnology
- SuperCT: a supervised-learning framework for enhanced characterization of single-cell transcriptomic profilesXie, Peng, Gao, Mingxuan, Wang, Chunming, Zhang, Jianfei, Noel, Pawan, Yang, Chaoyong, Von Hoff, Daniel, Han, Haiyong, Zhang, Michael Q, Lin, Wei · 2019 · Nucleic Acids Research
- Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemiaLee, Seung Hyun, Kim, Nayoung, Kim, Minkyu, Woo, Sang-Ho, Han, Inhee, Park, Jisu, Kim, Kyeongdae, Park, Kyu Seong, Kim, Kibyeong, Shim, Dahee et al. · 2022 · Nature Communications
- The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathologyLau, Shun-Fat, Wu, Wei, Wong, Hiu Yi, Ouyang, Li, Qiao, Yi, Xu, Jiahui, Lau, Jessica Hiu-Yan, Wong, Carlton, Jiang, Yuanbing, Holtzman, David M. et al. · 2023 · Nature Aging
- Exploring single cells in space and time during tissue development, homeostasis and regenerationMayr, Urs, Serra, Denise, Liberali, Prisca · 2019 · Development
- Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAsCates, Kitra, McCoy, Matthew J., Kwon, Ji-Sun, Liu, Yangjian, Abernathy, Daniel G., Zhang, Bo, Liu, Shaopeng, Gontarz, Paul, Kim, Woo Kyung, Chen, Shawei et al. · 2021 · Cell Stem Cell
- An interpretable deep-learning architecture of capsule networks for identifying cell-type gene expression programs from single-cell RNA-sequencing dataWang, Lifei, Nie, Rui, Yu, Zeyang, Xin, Ruyue, Zheng, Caihong, Zhang, Zhang, Zhang, Jiang, Cai, Jun · 2020 · Nature Machine Intelligence
- Uncovering axes of variation among single-cell cancer specimensChen, William S., Zivanovic, Nevena, van Dijk, David, Wolf, Guy, Bodenmiller, Bernd, Krishnaswamy, Smita · 2020 · Nature Methods
- Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screensXu, Zihan, Sziraki, Andras, Lee, Jasper, Zhou, Wei, Cao, Junyue · 2024 · Nature Biotechnology
- Generative modeling of single-cell gene expression for dose-dependent chemical perturbationsKana, Omar, Nault, Rance, Filipovic, David, Marri, Daniel, Zacharewski, Tim, Bhattacharya, Sudin · 2023 · Patterns
- Network control principles for identifying personalized driver genes in cancerGuo, Wei-Feng, Zhang, Shao-Wu, Zeng, Tao, Akutsu, Tatsuya, Chen, Luonan · 2020 · Briefings in Bioinformatics
- Differentiation reveals latent features of aging and an energy barrier in murine myogenesisKimmel, Jacob C., Yi, Nelda, Roy, Margaret, Hendrickson, David G., Kelley, David R. · 2021 · Cell Reports
- Exercise modifies the transcriptional regulatory features of monocytes in Alzheimer’s patients: a multi-omics integration analysis based on single cell technologyChen, Yisheng, Sun, Yaying, Luo, Zhiwen, Chen, Xiangjun, Wang, Yi, Qi, Beijie, Lin, Jinrong, Lin, Wei-Wei, Sun, Chenyu, Zhou, Yifan et al. · 2022 · Frontiers in Aging Neuroscience
- Single-Cell Computational Strategies for Lineage Reconstruction in Tissue SystemsHerring, Charles A., Chen, Bob, McKinley, Eliot T., Lau, Ken S. · 2018 · Cellular and Molecular Gastroenterology and Hepatology
- Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.Wang, Shuyong, Wang, Xuan, Shan, Yiran, Tan, Zuolong, Su, Yuxin, Cao, Yannan, Wang, Shuang, Dong, Jiahong, Gu, Jin, Wang, Yunfang · 2024 · Cell Stem Cell
- Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditisLi, Huihui, Chen, Xueting, Wang, James Jiqi, Shen, Juan, Abuduwufuer, Kudusi, Zhang, Zhao, Dong, Zhensheng, Wen, Zheng, He, Jingwei, Chen, Silian et al. · 2025 · Signal Transduction and Targeted Therapy
- Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancersWang, Yawei, Chen, Di, Liu, Yu, Shi, Daiwang, Duan, Chao, Li, Jinghan, Shi, Xiang, Zhang, Yong, Yu, Zhanwu, Sun, Nan et al. · 2023 · Cell Death & Disease
- Lung endothelium exploits susceptible tumor cell states to instruct metastatic latencyJakab, Moritz, Lee, Ki Hong, Uvarovskii, Alexey, Ovchinnikova, Svetlana, Kulkarni, Shubhada R., Jakab, Sevinç, Rostalski, Till, Spegg, Carleen, Anders, Simon, Augustin, Hellmut G. · 2024 · Nature Cancer
- Squidiff: predicting cellular development and responses to perturbations using a diffusion modelHe, Siyu, Zhu, Yuefei, Tavakol, Daniel Naveed, Ye, Haotian, Lao, Yeh-Hsing, Zhu, Zixian, Xu, Cong, Chauhan, Shradha, Garty, Guy, Tomer, Raju et al. · 2026 · Nature Methods
- A Comprehensive Survey of Statistical Approaches for Differential Expression Analysis in Single-Cell RNA Sequencing StudiesDas, Samarendra, Rai, Anil, Merchant, Michael L., Cave, Matthew C., Rai, Shesh N. · 2021 · Genes
- Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolutionMonberg, Maria E., Geiger, Heather, Lee, Jaewon J., Sharma, Roshan, Semaan, Alexander, Bernard, Vincent, Wong, Justin, Wang, Fang, Liang, Shaoheng, Swartzlander, Daniel B. et al. · 2022 · Nature Communications
- Cancer Cells Enter an Adaptive Persistence to Survive Radiotherapy and Repopulate TumorZhao, Yucui, Lu, Tingting, Song, Yanwei, Wen, Yanqin, Deng, Zheng, Fan, Jiahui, Zhao, Minghui, Zhao, Ruyi, Luo, Yuntao, xie, Jianzhu et al. · 2023 · Advanced Science
- APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s casesPerez-Corredor, Paula, Vanderleest, Timothy E., Vacano, Guido N., Sanchez, Justin S., Villalba-Moreno, Nelson D., Marino, Claudia, Krasemann, Susanne, Mendivil-Perez, Miguel A., Aguillón, David, Jiménez-Del-Río, Marlene et al. · 2024 · Frontiers in Molecular Neuroscience
- Differential gene expression analysis for multi-subject single-cell RNA-sequencing studies with<i>aggregateBioVar</i>Thurman, Andrew L, Ratcliff, Jason A, Chimenti, Michael S, Pezzulo, Alejandro A · 2021 · Bioinformatics
- Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor modelHachey, Stephanie J., Hatch, Christopher J., Gaebler, Daniela, Mocherla, Aneela, Nee, Kevin, Kessenbrock, Kai, Hughes, Christopher C. W. · 2024 · Breast Cancer Research
- Chromatin accessibility dynamics of myogenesis at single cell resolutionPliner, Hannah A., Packer, Jonathan, McFaline-Figueroa, José L., Cusanovich, Darren A., Daza, Riza, Srivatsan, Sanjay, Qiu, Xiaojie, Jackson, Dana, Minkina, Anna, Adey, Andrew et al. · 2017
- Ancestral developmental potentials in early bony fish contributed to vertebrate water-to-land transitionBi, Xu-Peng, 深圳华大基因,广东 深圳518083,中国, BGI-Shenzhen, Shenzhen, Guangdong 518083, China, Zhang, Guo-Jie, 中国科学院动物进化与遗传前沿交叉卓越创新中心,云南 昆明 650223,中国, 中国科学院昆明动物研究所遗传资源与进化国家重点实验室,云南 昆明 650223,中国, Villum Center for Biodiversity Genomics, Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Copenhagen DK-2100, Denmark, Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China, Villum Center for Biodiversity Genomics, Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark · 2021 · Zoological Research
- Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafishHuang, Delai, Kapadia, Emaan H., Liang, Yipeng, Shriver, Leah P., Dai, Shengkun, Patti, Gary J., Humbel, Bruno M., Laudet, Vincent, Parichy, David M. · 2025 · Proceedings of the National Academy of Sciences
- SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden2025
- Single-cell analyses reveal metastasis mechanism and microenvironment remodeling of lymph node in intrahepatic cholangiocarcinomaLi, Zhe, Ma, Lijie, Chen, Mengdi, Chen, Xing, Sha, Meng, Hang, Hualian · 2025 · JHEP Reports
- Cellular senescence in human liver under normal aging and cancerKarpova, Alla, Li, Xiang, Peng, Chien-Wei, Gallant, Kelsey L., Rapp, Daniel R., Alligood, Daniel M., Houston, Andrew J., Park, Alex, Targino da Costa, Andre Luiz N., Chou, Wen-hung et al. · 2026 · Cell Genomics
- Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liverSanchez Vasquez, Juan Diego, Nkongolo, Shirin, Traum, Daniel, Sotov, Valentin, Kim, Samuel C., Mahamed, Deeqa, Mehrotra, Aman, Patel, Anjali, Chen, Diana Y., Fung, Scott et al. · 2025 · Journal of Clinical Investigation
- Spatial Transcriptomics Unveils Regional Heterogeneity and Subclonal Dynamics in the Lung Adenocarcinoma MicroenvironmentAn, Haoyuan, Fang, Wei, Chen, Haiyan, Huang, Weiying, Liu, Hongbin, Zhang, Zhenlei, Zhao, Hanzhu, Zhang, Yanbing, Zhao, Miaoqing, Qiu, Jianfeng et al. · 2025 · Computer Methods and Programs in Biomedicine
- Chimeric brain models to study human glial-neuronal and macroglial-microglial interactionsJin, Mengmeng, Ma, Ziyuan, Zhang, Haiwei, Dang, Rui, Papetti, Ava V., Stillitano, Alessandro C., Zou, Lisa, Goldman, Steven A., Jiang, Peng · 2026 · Cell Reports
- ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturationBangru, Sushant, Chen, Jackie, Baker, Nicholas, Das, Diptatanu, Chembazhi, Ullas V., Derham, Jessica M., Chorghade, Sandip, Arif, Waqar, Alencastro, Frances, Duncan, Andrew W. et al. · 2025 · Genes & Development
- Type 1 interferon perturbates clonal competition by reshaping human blood developmentLama, Chhiring, Isakov, Danielle, Rosenberg, Shira, Quijada-Álamo, Miguel, Saurty-Seerunghen, Mirca S., Moein, Sara, Nozais, Mathis, Abera, Tsega-Ab, Sakaguchi, Olivia, Totwani, Mansi et al. · 2026 · Nature Genetics