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Context-dependent regulatory variants in Alzheimer’s diseasePreprint

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Pristimerin Alleviates Nanoparticulate Titanium Dioxide-Triggered Neurodegeneration in Hippocampal and Cortex by Downregulation of Inflammation and Oxidative Damage

Wang, Y., Zhang, G., Wang, L., Cheng, Z., & Zhao, Z. (2026) · Biological Trace Element Research · doi:10.1007/s12011-025-04928-z · Cited by 2 · see citing works

Confined migration induces non-lethal DNA damage in developing neurons

Zhang, Z., Canela, A., Kurisu, J., Zou, P., Kawaue, T., Nakazawa, N., Takeda, N., Saeki, M., Utsunomiya, M., Bilgic, M., et al. (2026) · Nature · doi:10.1038/s41586-026-10648-8 · Cited by 2 · see citing works

Circulating Cell Free DNA and DNA Double-Strand Breakage in Alzheimer’s Disease

Nguyen, M. V. L., Wood, C., Rios, A., Salter, Z., & Reddy, P. H. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-240012 · Cited by 2 · see citing works

Taming hyper-active Cdk5: Disrupting the Cdk5–p25 axis as a therapeutic avenue for neurodegeneration and beyond

Kamel, E. M., Alsalamah, S. A., Khadrawy, S. M., Ahmed, N. A., Alkhayl, F. F. A., & Lamsabhi, A. M. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156234 · Cited by 1 · see citing works

Gas6 restores microglial efferocytosis and limits neuroinflammation in neonatal hypoxic-ischemic encephalopathy by activating MerTK and the PI3K–Rac1 pathway

Liu, Y., Kasimu, A., Song, Y., Liu, J., Si, C., Chen, Q., Zhang, Y., Xie, L., Chen, D., & Li, B. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02911-2 · Cited by 1 · see citing works

A protective role for APP in nuclear waste clearance via lysosomal exocytosis

Dougnon, G., Otsuka, T., Nakamura, Y., Sakai, A., Yamanaka, T., Matsui, N., Nakahara, A., Ito, A., Hatano, A., Matsumoto, M., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2524190123 · Cited by 4 · see citing works

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

Hill, N., AlMuallim, H. Y. O., Maddock, E., Hobbs, C., Clarke, E. E., Goncalves, M. B. C. V., & Corcoran, J. P. T. (2026) · FEBS Open Bio · doi:10.1002/2211-5463.70284 · Cited by 1 · see citing works

Chronic IL-1-induced DNA double-strand break response in hippocampal neurons drives cognitive deficitsPreprint

Belloy, M., Schmitt, B. A. M., Marty, F. H., Paut, C., Emilie, B.-P., Aïda, A., Alis, M., Ecalard, R., Boursereau, R., Gonzalez‐Dunia, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.03.578747 · Cited by 1 · see citing works

Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegenerationPreprint

Cohen, S., Cheradame, L., Pratt, K. J. B., Collins, S. E., Barillas, A., Carlson, A., Ramani, V., Legube, G., Villeda, S., Mullins, R. D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.22.619740 · Cited by 1 · see citing works

The Divergent 3D Genome Landscapes of Aging and Neurodegenerative mouse modelsPreprint

Kashuk, E., Smirnov, D., Eremenko, E., Tsitrina, A. A., Kriukov, D. V., Golova, A., Kaluski-Kopatch, S., Khrameeva, E. E., & Toiber, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.10.687599 · Cited by 1 · see citing works

Senescence of cortical neurons following persistent DNA double-strand breaks induces cerebrovascular lesionsPreprint

Kopsidas, C. A., Lowe, C. C., Zhang, J., Kang, W., Zhou, X., & Feng, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525738

A Consensus Gene Regulatory Network for Neurodegenerative Diseases Using Single-Cell RNA-Seq Data

Koumadorakis, D. E., Krokidis, M. G., Dimitrakopoulos, G. Ν., & Vrahatis, A. G. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-31978-5_20

Runx3 and Brn3a interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron developmentPreprint

Orlovsky, K., Appel, E., Hantisteanu, S., Olender, T., Lotem, J., Levanon, D., & Groner, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4099142/v1

Current Understanding of ALS Onset, Progression and TreatmentsPreprint

Rossmiller, B. P., & Bagheri, M. (2024) · doi:10.14293/pr2199.001277.v1

Perturbations to Stimulus-Dependent Gene Activity Patterns in Neurodegenerative Disorders

Madabhushi, R., & Tsai, L. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_15

Spatial transcriptomics

Belalov, I., Wang, Y., Buzdin, A. A., & Li, X. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-19110-7.00003-3

Retrotransposon Activation in the Aged and Alzheimer’s Disease Brain Examined by Nanopore Long-read DNA SequencingPreprint

Kelsey, M. M. G., Chongtham, A., LaCava, J., Taylor, M. S., Boeke, J. D., Gage, F. H., Seluanov, A., Gorbunova, V. A., Pereira, A. C., & Sedivy, J. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.12.693943

Additional file 1 of Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration

Li, L.-J., Sun, X.-Y., Huang, Y., Lu, S., Xu, Y.-M., Yang, J., Xie, X.-X., Zhu, J., Niu, X.-Y., Wang, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26488356

L'implication des hybrides ADN : ARN et de la modification m6A des ARN dans la réparation des cassures double-brins de l'ADN

Saur, F. (2023) · doi:10.70675/dce63b34z1573z4c87z9c02z6d5c0807db2a

Disruption of DNA Repair as an Emerging Epigenetic Mechanism Underlying Autism Spectrum Disorder

Kelvington, B. A., Kim, J., Banerjee, S., Stevens, H. E., Chow, H., & Abel, T. G. (2026) · Current Psychiatry Reports · doi:10.1007/s11920-026-01684-2

Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives

wang, H., Yang, X., Wang, S., Yang, Z., Yang, X., Yang, Y., Li, Z., Ren, Y., Zhang, Q., Zhao, B., et al. (2026) · iMeta · doi:10.1002/imt2.70146

The double-edged sentinel: cGAS-STING as a context-dependent regulator of microglial senescence and neuronal genotoxic stress in neurodegeneration

Zhang, C., & Yang, Z. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112118 · Cited by 1 · see citing works

Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease

Welch, G. (2022) · DSpace@MIT (Massachusetts Institute of Technology)

DNA damage induced neuroinflammation in neurodegenerative disease

Song, X., Theeng Mei, A. W., Ma, F., Leung, D., & Herrup, K. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.047445 · Cited by 6 · see citing works

Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes

Mecca, C., Giambanco, I., Donato, R., & Arcuri, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010318 · Cited by 259 · see citing works

Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage

Arvanitaki, E. S., Goulielmaki, E., Gkirtzimanaki, K., Niotis, G., Tsakani, E., Nenedaki, E., Rouska, I., Kefalogianni, M., Xydias, D., Kalafatakis, I., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317402121 · Cited by 50 · see citing works

Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double‐stranded RNA

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