Cited by 682Genomics and Phylogenetic StudiesGene expression and cancer classificationGenomic variations and chromosomal abnormalities

Direct selection of human genomic loci by microarray hybridization

Albert, Thomas J, Molla, Michael N, Muzny, Donna M, Nazareth, Lynne, Wheeler, David, Song, Xingzhi, Richmond, Todd A, Middle, Chris M +4 more·2007·Nature Methods

Abstract

We applied high-density microarrays to the enrichment of specific sequences from the human genome for high-throughput sequencing. After capture of 6,726 approximately 500-base 'exon' segments, and of 'locus-specific' regions ranging in size from 200 kb to 5 Mb, followed by sequencing on a 454 Life Sciences FLX sequencer, most sequence reads represented selection targets. These direct selection methods supersede multiplex PCR for the large-scale analysis of genomic regions.

Integrity signals

Registry

Crossref · 10.1038/nmeth1111

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Highly parallel methods to capture hundreds of thousands of exons, and other targets of interest, are under development.

    “Highly parallel methods to capture hundreds of thousands of exons, and other targets of interest, are under development (139).”

    From Genetic Mapping in Human Disease (2008) · cites this paper as [139]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Albert, T. J., Molla, M. N., Muzny, D. M., Nazareth, L., Wheeler, D., Song, X., Richmond, T. A., Middle, C. M., Rodesch, M. J., Packard, C. J., Weinstock, G. M., & Gibbs, R. A.
Corresponding author
  • Albert, Thomas J
  • Gibbs, Richard A
Venue
Nature Methods
Published
2007-10-14
Volume
4
Issue
11
Pages
903-905
ISSN
  • 1548-7091 (ISSN-L)
  • 1548-7105
OpenAlex
W1969596239
Cited by
681
References
8
Citations by year
2026: 6 · 2025: 10 · 2024: 33 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 11 · 2019: 21 · 2018: 26 · 2017: 20 · 2016: 26 · 2015: 31 · 2014: 41 · 2013: 50 · 2012: 63
FWCI
29.97
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Methods (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Human Genome Research Institute (R21HG004553, U54HG003273)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords
microarray hybridization, high-density microarrays, exon capture, next-generation sequencing, 454 pyrosequencing, human genome
MeSH terms
Humans, Nucleic Acid Hybridization, Oligodeoxyribonucleotides, Gene Library, Genome, Human, Polymerase Chain Reaction, Sequence Analysis, DNA, BRCA1 Protein, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Cell Line, Tumor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review