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Cited by 284

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis

Open access
Mishra, Bibhuti B., Lovewell, Rustin R., Olive, Andrew J., Zhang, Guoliang, Wang, Wenfei, Eugenin, Eliseo, Smith, Clare M., Phuah, Jia Yao, Long, Jarukit E., Dubuke, Michelle L., Palace, Samantha G., Goguen, Jon D., Baker, Richard E., Nambi, Subhalaxmi, Mishra, Rabinarayan, Booty, Matthew G., Baer, Christina E., Shaffer, Scott A., Dartois, Veronique, McCormick, Beth A., Chen, Xinchun, Sassetti, Christopher M.·2017·Nature Microbiology
DOI 10.1038/nmicrobiol.2017.72
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Abstract

Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents subsequent pathological inflammation. In contrast, we report that nitric oxide primarily protects mice by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade that promotes bacterial replication. Using M. tuberculosis mutants as indicators of the pathogen's environment, we inferred that granulocytic inflammation generates a nutrient-replete niche that supports M. tuberculosis growth. Parallel clinical studies indicate that a similar inflammatory pathway promotes tuberculosis in patients. The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavitary tuberculosis lesions; the abundance of its products correlates with the number of airway neutrophils and bacterial burden and a genetic polymorphism that increases ALOX12 expression is associated with tuberculosis risk. These data suggest that M. tuberculosis exploits neutrophilic inflammation to preferentially replicate at sites of tissue damage that promote contagion.

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Metadata

Authors
Mishra, B. B., Lovewell, R. R., Olive, A. J., Zhang, G., Wang, W., Eugenin, E., Smith, C. M., Phuah, J. Y., Long, J. E., Dubuke, M. L., Palace, S. G., Goguen, J. D., Baker, R. E., Nambi, S., Mishra, R., Booty, M. G., Baer, C. E., Shaffer, S. A., Dartois, V., McCormick, B. A., Chen, X., & Sassetti, C. M.
Venue
Nature Microbiology
Publisher
Springer Science and Business Media LLC
Published
2017-05-15
Volume
2
Issue
7
Pages
17072-17072
ISSN
2058-5276 (ISSN-L)
DOI
10.1038/nmicrobiol.2017.72
OpenAlex
W2614705174
Cited by
284
References
48
FWCI
20.26
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.