Laminar and compartmental regulation of dendritic growth in mature cortex
Open accessAbstract
Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.
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Dendrite length, complexity, and synaptic turnover are well controlled during neuronal development, remain rather stable in many cortical areas during adulthood, yet a subset of synapses exhibit life-long cell type-specific, experience-dependent plasticity.
“Dendrite length, complexity and synaptic turnover are well controlled during neuronal development, remain rather stable in many cortical areas during adulthood, yet a subset of synapses are thought to exhibit life-long cell type-specific, experience-dependent plasticity (Chow et al., 2009;De Paola et al., 2006;Kasai et al., 2010;Trachtenberg et al., 2002).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Chow et al., 2009
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Experimental — accuracy not yet measuredPTEN and mTOR are not involved in induction of dendritic plasticity in layer 5 pyramidal neurons.
“PTEN and mTOR were not involved in induction of dendritic plasticity in layer 5 pyramidal neurons.71”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [71]
PTEN and mTOR induce sprouting of apical but not basal dendrites of mouse cortical layer 2/3 pyramidal neurons.
“The tumour suppressor phosphatase and tensin homolog (PTEN) and its downstream target mammalian target of rapamycin (mTOR), for example, were shown to induce the sprouting of apical but not basal dendrites of mouse cortical layer 2/3 pyramidal neurons.71”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [71]
Loss of PTEN causes continuous growth of L2/3 pyramidal neuron apical dendrites and expansion of the mature cortex.
“In contrast, absence of the tumor suppressor protein, phosphatase and tensin homolog (PTEN), results in continuous growth of L2/3 pyramidal neuron apical dendrites and expansion of the mature cortex [22].”
From Experience-dependent structural plasticity in the cortex (2011) · cites this paper as [22]
In the cerebral cortex, spines are constantly formed and eliminated.
“In the cerebral cortex, while dendritic branches are mostly stable over time (Trachtenberg et al., 2002; Mizrahi and Katz, 2003; Chow et al., 2009; Mostany and Portera-Cailliau, 2011; Schubert et al., 2013), spines are constantly formed and eliminated.”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Chow et al., 2009
In the cerebral cortex, dendritic branches are mostly stable over time.
“In the cerebral cortex, while dendritic branches are mostly stable over time (Trachtenberg et al., 2002; Mizrahi and Katz, 2003; Chow et al., 2009; Mostany and Portera-Cailliau, 2011; Schubert et al., 2013), spines are constantly formed and eliminated.”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Chow et al., 2009
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Cites
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- Authors
- Chow, D. K., Groszer, M., Pribadi, M., Machniki, M., Carmichael, S. T., Liu, X., & Trachtenberg, J. T.
- Affiliations
- University of California, Los Angeles (US)
- Inserm (FR)
- Corresponding author
- Trachtenberg, Joshua T
- Venue
- Nature Neuroscience
- Published
- 2009-01-18
- Volume
- 12
- Issue
- 2
- Pages
- 116-118
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2842592
- OpenAlex
- W2076748846
- Cited by
- 113
- References
- 11
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 5 · 2017: 12 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 15
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH68172, U54MH068172)
- National Eye Institute (EY016052, R01EY016052)
- National Institute of General Medical Sciences (GM-07185, T32GM007185)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- dendritic growth, mature neurons, PTEN, mTOR signaling, pyramidal neurons, basal dendrites, tumor suppressor loss, cortical development, dendritic compartmentalization
- MeSH terms
- Age Factors, Animals, Antibiotics, Antineoplastic, Carrier Proteins, Cerebral Cortex, Dendrites, Humans, Signal Transduction, Phosphotransferases (Alcohol Group Acceptor), Pyramidal Cells, Gene Expression Regulation, Developmental, Sirolimus, PTEN Phosphohydrolase, Mice, TOR Serine-Threonine Kinases
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