Intra-retinal visual cycle required for rapid and complete cone dark adaptation

Wang, Jin-Shan; Estevez, Maureen E; Cornwall, M Carter; Kefalov, Vladimir J

doi:10.1038/nn.2258

Cited by 151Retinal Development and DisordersPhotoreceptor and optogenetics researchRetinal Diseases and Treatments

Intra-retinal visual cycle required for rapid and complete cone dark adaptation

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Wang, Jin-Shan, Estevez, Maureen E, Cornwall, M Carter, Kefalov, Vladimir J·2009·Nature Neuroscience

DOI 10.1038/nn.2258PMC PMC2707787

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Abstract

Daytime vision is mediated by retinal cones, which, unlike rods, remain functional even in bright light and dark-adapt rapidly. These cone properties are enabled by rapid regeneration of their pigment. This in turn requires rapid chromophore recycling that may not be achieved by the canonical retinal pigment epithelium visual cycle. Recent biochemical studies have suggested the presence of a second, cone-specific visual cycle, although its physiological function remains to be established. We found that the Müller cells in the salamander neural retina promote cone-specific pigment regeneration and dark adaptation that are independent of the pigment epithelium. Without this pathway, dark adaptation of cones was slow and incomplete. Notably, the rates of cone pigment regeneration by the retina and pigment epithelium visual cycles were essentially identical, suggesting a possible common rate-limiting step. Finally, we also observed cone dark adaptation in the isolated mouse retina.

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In salamander, cones in an isolated retina lacking RPE regain light sensitivity after bleaching, while bleached cones separated from the retina do not.
“Salamander cones maintained within an isolated retina free of the RPE recover light sensitivity after bleaching; however, this recovery disappears in bleached cones disassociated from the retina (Wang et al., 2009).”
From New insights into retinoid metabolism and cycling within the retina (2013) · cites this paper as Wang et al., 2009
Inner retinal ARAT activity is associated with chicken Müller cells in primary culture.
“Studies involving primary cultures of chicken Müller cells indicate that inner retinal ARAT enzymatic activity is associated with this cell type.85,302,431”
From Chemistry of the Retinoid (Visual) Cycle (2014) · cites this paper as [431]
The Results section, “Müller Cells are Part of the Retina Visual Cycle” (page unavailable), links Müller cells to cone pigment regeneration in isolated salamander retina. It does not report ARAT activity or experiments with primary cultures of chicken Müller cells; searches for ARAT and cultured chicken Müller cells found no such passage in our copy. (LLM, conf=0.76)
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E.: “A Summary of
Wang, J.-S., Estevez, M. E., Cornwall, M. C., & Kefalov, V. J. (1968)
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The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently of the Interphotoreceptor Retinoid-Binding Protein
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An Alternative Pathway Mediates the Mouse and Human Cone Visual Cycle
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The Cone-specific visual cycle
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cis Retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration
Sato, S., & Kefalov, V. J. (2016) · The Journal of Physiology · doi:10.1113/jp272831 · Cited by 35 · see citing works
Self-citation

Authors: Wang, J.-S., Estevez, M. E., Cornwall, M. C., & Kefalov, V. J.
Affiliations: Boston University (US)
Washington University in St. Louis (US)
Corresponding author: Kefalov, Vladimir J
ORCID: Cornwall, M Carter
Kefalov, Vladimir J
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-02-01
Volume: 12
Issue: 3
Pages: 295-302
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.2258
PMC: PMC2707787
OpenAlex: W2103344716
Cited by: 151
References: 38
Citations by year: 2026: 4 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 16 · 2018: 10 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 11 · 2012: 11
FWCI: 6.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Foundation for the National Institutes of Health
Karl Kirchgessner Foundation
Research to Prevent Blindness
National Eye Institute (EY 02687, P30EY002687, EY-01157, R01EY019312, R01EY001157, EY019312)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Keywords: visual cycle, Müller cells, cone photoreceptors, retinal pigment epithelium, salamander retina, mouse retina, retinal pigment
MeSH terms: Ambystoma, Animals, Dark Adaptation, Electroretinography, Mice, Inbred C57BL, Photic Stimulation, Retina, Time Factors, Caudata, Urodela, Visual Perception, Retinal Cone Photoreceptor Cells, Photoreceptor Cells, Vertebrate, Mice

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Intra-retinal visual cycle required for rapid and complete cone dark adaptation

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