An Alternative Pathway Mediates the Mouse and Human Cone Visual Cycle

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

Cideciyan, A. V., Alemán, T. S., Boye, S. L., Schwartz, S., Kaushal, S., Román, A. J., Pang, J., Sumaroka, A., Windsor, E. A. M., Wilson, J. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807027105 · Cited by 674 · see citing works

The Murine Cone Photoreceptor

Applebury, M. L., Antoch, M. P., Baxter, L. C., Chun, L. L. Y., Falk, J. D., Farhangfar, F., Kage, K., Krzystolik, M. G., Lyass, L., & Robbins, J. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)00062-3 · Cited by 566 · see citing works

Vertebrate Photoreceptors

Ebrey, T. G., & Koutalos, Y. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00014-8 · Cited by 441 · see citing works

Diseases Caused by Defects in the Visual Cycle: Retinoids as Potential Therapeutic Agents

Travis, G. H., Golczak, M., Moise, A. R., & Palczewski, K. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105225 · Cited by 419 · see citing works

Isomerization and Oxidation of Vitamin A in Cone-Dominant Retinas

Mata, N. L., Radu, R. A., Clemmons, R. S., & Travis, G. H. (2002) · Neuron · doi:10.1016/s0896-6273(02)00912-1 · Cited by 382 · see citing works

The Ferrier Lecture, 1962 Visual adaptation

Rushton, W. A. H. (1965) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1965.0024 · Cited by 354 · see citing works

Physiological Features of the S- and M-cone Photoreceptors of Wild-type Mice from Single-cell Recordings

Nikonov, S. S., Kholodenko, R. V., Lem, J., & Pugh, E. N. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609490 · Cited by 298 · see citing works

Biochemistry of visual pigment regeneration: the Friedenwald lecture.

Saari, J. C. (2000) · PubMed · Cited by 243 · see citing works

Intra-retinal visual cycle required for rapid and complete cone dark adaptation

Wang, J.-S., Estevez, M. E., Cornwall, M. C., & Kefalov, V. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2258 · Cited by 151 · see citing works

A dissection of the electroretinogram from the isolated rat retina with microelectrodes and drugs

Green, D. G., & KAPOUSTA-BRUNEAU, N. V. (1999) · Visual Neuroscience · doi:10.1017/s0952523899164125 · Cited by 144 · see citing works

Photoreceptors of Nrl −/− Mice Coexpress Functional S- and M-cone Opsins Having Distinct Inactivation Mechanisms

Nikonov, S. S., Daniele, L. L., Zhu, X., Craft, C. M., Swaroop, A., & Pugh, E. N. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200409208 · Cited by 138 · see citing works

Muller cells of chicken retina synthesize 11- <i>cis</i> -retinol

Das, S. R., Bhardwaj, N., Kjeldbye, H., & Gouras, P. (1992) · Biochemical Journal · doi:10.1042/bj2850907 · Cited by 135 · see citing works

Signaling Properties of a Short-Wave Cone Visual Pigment and Its Role in Phototransduction

Shi, G., Yau, K., Chen, J., & Kefalov, V. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2211-07.2007 · Cited by 76 · see citing works

Subfunctionalization of a Retinoid-Binding Protein Provides Evidence for Two Parallel Visual Cycles in the Cone-Dominant Zebrafish Retina

Fleisch, V. C., Schonthaler, H. B., von Lintig, J., & Neuhauss, S. C. F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2367-08.2008 · Cited by 68 · see citing works

Visual pigment bleaching in isolated salamander retinal cones. Microspectrophotometry and light adaptation.

Jones, G. J., Fein, A., MacNichol, E. F., & Cornwall, M. C. (1993) · The Journal of General Physiology · doi:10.1085/jgp.102.3.483 · Cited by 66 · see citing works

RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice

Wenzel, A., von Lintig, J., Oberhauser, V., Tanimoto, N., Grimm, C., & Seeliger, M. W. (2007) · Investigative Opthalmology &amp; Visual Science · doi:10.1167/iovs.06-0652 · Cited by 66 · see citing works

Effects of inhibiting glutamine synthetase and blocking glutamate uptake on b-wave generation in the isolated rat retina

Winkler, B. S., KAPOUSTA-BRUNEAU, N. V., ARNOLD, M. J., & Green, D. G. (1999) · Visual Neuroscience · doi:10.1017/s095252389916214x · Cited by 58 · see citing works

Do N-methyl-D-aspartate receptors mediate synaptic responses in the mudpuppy retina?

Coleman, P. A., & Miller, R. F. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04728.1988 · Cited by 47 · see citing works

NBQX, an improved non-NMDA antagonist studied in retinal ganglion cells

Yu, W., & Miller, R. F. (1995) · Brain Research · doi:10.1016/0006-8993(95)00665-d · Cited by 46 · see citing works

Nrl -Knockout Mice Deficient in Rpe65 Fail to Synthesize 11- cis Retinal and Cone Outer Segments

Feathers, K. L., Lyubarsky, A., Khan, N. W., Teofilo, K., Swaroop, A., Williams, D. S., Pugh, E. N., & Thompson, D. A. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1234 · Cited by 44 · see citing works

Mouse cone photoresponses obtained with electroretinogram from the isolated retina

Heikkinen, H. A., Nymark, S., & Koskelainen, A. (2008) · Vision Research · doi:10.1016/j.visres.2007.11.005 · Cited by 42 · see citing works

Light adaptation and the rising phase of the flash photocurrent of salamander retinal rods.

Jones, G. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020891 · Cited by 39 · see citing works

Influence of laminin-2 on Schwann cell-axon interactions

Uziyel, Y., Hall, S., & Cohen, J. (2000) · Glia · doi:10.1002/1098-1136(200011)32:2 · Cited by 36 · see citing works

Retinoid cycles in the cone-dominated chicken retina

Trevino, S. G., Villazana-Espinoza, E. T., Muniz, A., & Tsin, A. T. C. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01881 · Cited by 31 · see citing works

Retinyl ester hydrolase and the visual cycle in the chicken eye

Bustamante, J. J., Ziari, S., Ramirez, R. D., & Tsin, A. T. C. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.6.r1346 · Cited by 16 · see citing works

A New Method for Measuring Free Drug Concentration: Retinal Tissue as a Biosensor

Nymark, S., Haldin, C., Tenhu, H. J., & Koskelainen, A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1116 · Cited by 13 · see citing works

Effect of light exposure on the accumulation and depletion of retinyl ester in the chicken retina

Villazana-Espinoza, E. T., Hatch, A. L., & Tsin, A. T. C. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.04.011 · Cited by 13 · see citing works

An adaptive ERG technique to measure normal and altered dark adaptation in the mouse

DeMarco, P. J., Katagiri, Y., Enzmann, V., Kaplan, H. J., & McCall, M. A. (2007) · Documenta Ophthalmologica · doi:10.1007/s10633-007-9078-5 · Cited by 8 · see citing works

The Retinal Pigment Epithelium in Health and Disease

Sparrrow, J. R., Hicks, D., & Hamel, C. (2010) · Current Molecular Medicine · doi:10.2174/156652410793937813 · Cited by 625 · see citing works

Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions

Schmidt, T. M., Chen, S., & Hattar, S. S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.001 · Cited by 553 · see citing works

Intrinsically Photosensitive Retinal Ganglion Cells

Do, M. T. H., & Yau, K. (2010) · Physiological Reviews · doi:10.1152/physrev.00013.2010 · Cited by 477 · see citing works

The Cone-specific visual cycle

Wang, J.-S., & Kefalov, V. J. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.11.001 · Cited by 335 · see citing works

A comprehensive review of retinal gene therapy

Boye, S. E., Boye, S. L., Lewin, A. S., & Hauswirth, W. W. (2013) · Molecular Therapy · doi:10.1038/mt.2012.280 · Cited by 262 · see citing works

Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy

Cideciyan, A. V. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.04.002 · Cited by 256 · see citing works

Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool

van Wyk, M., Pielecka-Fortuna, J., Löwel, S., & Kleinlogel, S. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002143 · Cited by 205 · see citing works

Vitamin A Metabolism in Rod and Cone Visual Cycles

Saari, J. C. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150748 · Cited by 189 · see citing works

Spectral and Temporal Sensitivity of Cone-Mediated Responses in Mouse Retinal Ganglion Cells

Wang, Y. V., Weick, M., & Demb, J. B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0629-11.2011 · Cited by 181 · see citing works

Key enzymes of the retinoid (visual) cycle in vertebrate retina

Kiser, P. D., Golczak, M., Maeda, A., & Palczewski, K. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.03.005 · Cited by 177 · see citing works

Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm

Markwell, E. L., Feigl, B., & Zele, A. J. (2010) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2010.00479.x · Cited by 159 · see citing works

Rods progressively escape saturation to drive visual responses in daylight conditions

Kling, A., Reinhard, K., Storchi, R., Dietter, J., Seitter, H., Davis, K. E., Idrees, S., Mutter, M., Walmsley, L., Bedford, R. A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01816-6 · Cited by 142 · see citing works

Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

Bazan, N. G., Calandria, J. M., & Serhan, C. N. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r001131 · Cited by 140 · see citing works

Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells

Morshedian, A., Kaylor, J. J., Ng, S. Y., Tsan, A., Frederiksen, R., Xu, T., Yuan, L., Sampath, A. P., Radu, R. A., Fain, G., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.004 · Cited by 131 · see citing works

CRALBP supports the mammalian retinal visual cycle and cone vision

Xue, Y., Shen, S. Q., Jui, J., Rupp, A. C., Byrne, L. C., Hattar, S. S., Flannery, J. G., Corbo, J. C., & Kefalov, V. J. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79651 · Cited by 120 · see citing works

Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches

Kefalov, V. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.303008 · Cited by 114 · see citing works

Animal Models of Retinal Disease

Fletcher, E. L., Jobling, A. I., Vessey, K. A., Luu, C. D., Guymer, R. H., & Baird, P. N. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-384878-9.00006-6 · Cited by 109 · see citing works

The Role of Vitamin A in Retinal Diseases

Sajovic, J., Meglič, A., Glavač, D., Markelj, Š., Hawlina, M., & Fakin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031014 · Cited by 109 · see citing works

Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina

Kaylor, J. J., Yuan, Q., Cook, J., Sarfare, S., Makshanoff, J., Miu, A., Kim, A., Kim, P., Habib, S., Roybal, C. N., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1114 · Cited by 107 · see citing works

Intrinsically photosensitive retinal ganglion cells

Pickard, G. E., & Sollars, P. J. (2010) · Science China Life Sciences · doi:10.1007/s11427-010-0024-5 · Cited by 106 · see citing works

Differential Cone Pathway Influence on Intrinsically Photosensitive Retinal Ganglion Cell Subtypes

Schmidt, T. M., & Kofuji, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3656-10.2010 · Cited by 104 · see citing works

Vitamin A and Vision

Saari, J. C. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-024-0945-1_9 · Cited by 106 · see citing works

Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2

de Melo, J., Miki, K., Rattner, A., Smallwood, P. M., Zibetti, C., Hirokawa, K. E., Monuki, E. S., Campochiaro, P. A., & Blackshaw, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107488109 · Cited by 101 · see citing works

Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy

Hunter, J. J., Masella, B. D., Dubra, A., Sharma, R., Yin, L., Merigan, W. H., Palczewska, G., Palczewski, K., & Williams, D. R. (2010) · Biomedical Optics Express · doi:10.1364/boe.2.000139 · Cited by 99 · see citing works

Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations

Zhang, N., Tsybovsky, Y., Kolesnikov, A. V., Rôżanowska, M., Świder, M., Schwartz, S., Stone, E. M., Palczewska, G., Maeda, A., Kefalov, V. J., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv073 · Cited by 98 · see citing works

Fundus Albipunctatus Associated with Compound Heterozygous Mutations in RPE65

Schatz, P., Preising, M. N., Lorenz, B., Sander, B., Larsen, M., & Rosenberg, T. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2010.09.005 · Cited by 97 · see citing works

Intrinsically Photosensitive Retinal Ganglion Cells

Pickard, G. E., & Sollars, P. J. (2011) · Springer eBooks · doi:10.1007/112_2011_4 · Cited by 94 · see citing works

Metabolism of carotenoids and retinoids related to vision

von Lintig, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.303990 · Cited by 91 · see citing works

Shedding new light on the generation of the visual chromophore

Palczewski, K., & Kiser, P. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008211117 · Cited by 88 · see citing works

Reprogramming of adult rod photoreceptors prevents retinal degeneration

Montana, C. L., Kolesnikov, A. V., Shen, S. Q., Myers, C. A., Kefalov, V. J., & Corbo, J. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214387110 · Cited by 86 · see citing works

Melanopsin and Mechanisms of Non-visual Ocular Photoreception

Sexton, T. J., Buhr, E. D., & Gelder, R. N. V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.301226 · Cited by 77 · see citing works

Fifty years of dark adaptation 1961–2011

Reuter, T. (2011) · Vision Research · doi:10.1016/j.visres.2011.08.021 · Cited by 73 · see citing works

RPE65 gene therapy slows cone loss in Rpe65-deficient dogs

Mowat, F. M., Breuwer, A. R., Bartoe, J. T., Annear, M. J., Zhang, Z., Smith, A. J., Bainbridge, J. W., Petersen‐Jones, S. M., & Ali, R. R. (2012) · Gene Therapy · doi:10.1038/gt.2012.63 · Cited by 65 · see citing works

The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently of the Interphotoreceptor Retinoid-Binding Protein

Kolesnikov, A. V., Tang, P. H., Parker, R. O., Crouch, R. K., & Kefalov, V. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0438-11.2011 · Cited by 59 · see citing works

Multimodal Characterization of Proliferative Diabetic Retinopathy Reveals Alterations in Outer Retinal Function and Structure

Boynton, G. E., Stem, M. S., Kwark, L., Jackson, G. R., Farsiu, S., & Gardner, T. W. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2014.12.001 · Cited by 58 · see citing works

Voltage-clamp recordings of light responses from wild-type and mutant mouse cone photoreceptors

Ingram, N. T., Sampath, A. P., & Fain, G. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201912419 · Cited by 52 · see citing works

Light responses of primate and other mammalian cones

Cao, L.-H., Luo, D.-G., & Yau, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400268111 · Cited by 51 · see citing works

Molecular components affecting ocular carotenoid and retinoid homeostasis

von Lintig, J., Moon, J., & Babino, D. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100864 · Cited by 50 · see citing works

Interphotoreceptor Retinoid-Binding Protein as the Physiologically Relevant Carrier of 11-<i>cis-</i>Retinol in the Cone Visual Cycle

Parker, R., Wang, J.-S., Kefalov, V. J., & Crouch, R. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3722-10.2011 · Cited by 49 · see citing works

Revival of light signalling in the postmortem mouse and human retina

Abbas, F., Becker, S., Jones, B. W., Mure, L. S., Panda, S., Hanneken, A. M., & Vinberg, F. (2022) · Nature · doi:10.1038/s41586-022-04709-x · Cited by 49 · see citing works

Persistence of non-viral vector mediated RPE65 expression: Case for viability as a gene transfer therapy for RPE-based diseases

Koirala, A., Conley, S. M., Makkia, R., Liu, Z., Cooper, M. J., Sparrow, J. R., & Naash, M. I. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.299 · Cited by 47 · see citing works

RPE65 Is Present in Human Green/Red Cones and Promotes Photopigment Regeneration in an<i>In Vitro</i>Cone Cell Model

Tang, P. H., Buhusi, M. C., Ma, J.-X., & Crouch, R. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4265-11.2011 · Cited by 45 · see citing works

Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia

Tworak, A., Kolesnikov, A. V., Hong, J. D., Choi, E. H., Luu, J. C., Palczewska, G., Dong, Z., Lewandowski, D., Brooks, M. J., Campello, L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112982 · Cited by 44 · see citing works

In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones

Sharma, R., Schwarz, C., Williams, D. R., Palczewska, G., Palczewski, K., & Hunter, J. J. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17946 · Cited by 43 · see citing works

LACK OF AUTOFLUORESCENCE IN FUNDUS ALBIPUNCTATUS ASSOCIATED WITH MUTATIONS IN RDH5

Schatz, P., Preising, M., Lorenz, B., Sander, B., Larsen, M., Eckstein, C., & Rosenberg, T. (2010) · Retina · doi:10.1097/iae.0b013e3181dc050a · Cited by 44 · see citing works

Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans

Abbas, F., & Vinberg, F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.662453 · Cited by 41 · see citing works

Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa

MacLachlan, T. K., Milton, M. N., Turner, O., Tukov, F., Choi, V. W., Penraat, J., Hanks, S. M., Vrouvlianis, J., Leehy, B., Li, H., et al. (2018) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2017.12.001 · Cited by 40 · see citing works

Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling

Moore-Dotson, J. M., Beckman, J. J., Mazade, R. E., Hoon, M., Bernstein, A. S., Romero-Aleshire, M. J., Brooks, H. L., & Eggers, E. D. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17999 · Cited by 39 · see citing works

Retinal Gene Expression and Visually Evoked Behavior in Diabetic Long Evans Rats

Kirwin, S. J., Kanaly, S. T., Hansen, C. R., Cairns, B., Ren, M., & Edelman, J. L. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6609 · Cited by 39 · see citing works

Parallel visual cycles in the zebrafish retina

Fleisch, V. C., & Neuhauss, S. C. F. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.05.001 · Cited by 38 · see citing works

Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease

Zeng, S., Zhang, T., Madigan, M. C., Fernando, N., Aggio-Bruce, R., Zhou, F., Pierce, M., Chen, Y., Huang, L., Natoli, R., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577935 · Cited by 37 · see citing works

AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice

Choi, V. W., Bigelow, C. E., McGee, T. L., Gujar, A. N., Li, H., Hanks, S. M., Vrouvlianis, J., Maker, M., Leehy, B., Zhang, Y., et al. (2015) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1038/mtm.2015.22 · Cited by 35 · see citing works

cis Retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration

Sato, S., & Kefalov, V. J. (2016) · The Journal of Physiology · doi:10.1113/jp272831 · Cited by 35 · see citing works

The Retina-Based Visual Cycle

Sato, S., & Kefalov, V. J. (2024) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100820-083937 · Cited by 32 · see citing works

AMPA receptor mediated d ‐serine release from retinal glial cells

Sullivan, S. J., & Miller, R. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07077.x · Cited by 32 · see citing works

Simultaneous ex vivo Functional Testing of Two Retinas by in vivo Electroretinogram System

Vinberg, F., & Kefalov, V. J. (2015) · Journal of Visualized Experiments · doi:10.3791/52855 · Cited by 31 · see citing works

Autophagy in the eye: from physiology to pathophysiology

Liton, P. B., Boesze‐Battaglia, K., Boulton, M. E., Boya, P., Ferguson, T. A., Ganley, I. G., Kauppinen, A., Laurie, G. W., Mizushima, N., Morishita, H., et al. (2023) · Autophagy Reports · doi:10.1080/27694127.2023.2178996 · Cited by 29 · see citing works

Lamprey vision: Photoreceptors and organization of the retina

Fain, G. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.10.008 · Cited by 29 · see citing works

Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin

Wunderlich, K. A., Tanimoto, N., Grosche, A., Zrenner, E., Pekny, M., Reichenbach, A., Seeliger, M. W., Pannicke, T., & Perez, M.-T. (2015) · The FASEB Journal · doi:10.1096/fj.15-272963 · Cited by 29 · see citing works

Chromophore Supply Rate-Limits Mammalian Photoreceptor Dark Adaptation

Wang, J., Nymark, S., Frederiksen, R., Stabio, M. E., Shen, S. Q., Corbo, J. C., Cornwall, M. C., & Kefalov, V. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1245-14.2014 · Cited by 28 · see citing works

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function

Kiser, P. D., Zhang, J., Sharma, A., Angueyra, J. M., Kolesnikov, A. V., Badiee, M., Tochtrop, G. P., Kinoshita, J., Peachey, N. S., Li, W., et al. (2018) · The Journal of General Physiology · doi:10.1085/jgp.201711815 · Cited by 28 · see citing works

Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning

Rhim, I., Coello‐Reyes, G., & Nauhaus, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-90650-4 · Cited by 27 · see citing works

Inhibition to retinal rod bipolar cells is regulated by light levels

Eggers, E. D., Mazade, R. E., & Klein, J. S. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00872.2012 · Cited by 27 · see citing works

An alternative isomerohydrolase in the retinal Müller cells of a cone‐dominant species

Takahashi, Y., Moiseyev, G. P., Chen, Y., Nikolaeva, O., & Ma, J. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08216.x · Cited by 26 · see citing works

Circadian and light-driven regulation of rod dark adaptation

Xue, Y., Shen, S. Q., Corbo, J. C., & Kefalov, V. J. (2015) · Scientific Reports · doi:10.1038/srep17616 · Cited by 26 · see citing works

Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells

Flood, M. D., Moore-Dotson, J. M., & Eggers, E. D. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00855.2017 · Cited by 25 · see citing works

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision

Ward, R. H. R., Kaylor, J. J., Cobice, D., Pepe, D. A., McGarrigle, E. M., Brockerhoff, S. E., Hurley, J. B., Travis, G. H., & Kennedy, B. N. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011374 · Cited by 25 · see citing works

Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling

Wei, M., Sun, Y., Li, S., Chen, Y., Li, L., Fang, M., Shi, R., Tong, D., Chen, J., Ma, Y., et al. (2023) · Protein & Cell · doi:10.1093/procel/pwad007 · Cited by 25 · see citing works

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones

Kiser, P. D., Kolesnikov, A. V., Kiser, J. Z., Dong, Z., Chaurasia, B., Wang, L., Summers, S. A., Hoang, T. V., Blackshaw, S., Peachey, N. S., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802493r · Cited by 24 · see citing works

Regeneration of Photopigment Is Enhanced in Mouse Cone Photoreceptors Expressing RPE65 Protein

Tang, P. H., Wheless, L., & Crouch, R. K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0182-11.2011 · Cited by 24 · see citing works

The role of retinol dehydrogenase 10 in the cone visual cycle

Xue, Y., Sato, S., Razafsky, D. S., Sahu, B., Shen, S. Q., Potter, C., Sandell, L. J., Corbo, J. C., Palczewski, K., Maeda, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02549-8 · Cited by 24 · see citing works

Ground squirrel – A cool model for a bright vision

Li, W. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.06.005 · Cited by 23 · see citing works

Light responses of mammalian cones

Fain, G., & Sampath, A. P. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02551-0 · Cited by 23 · see citing works

Light adaptation alters the source of inhibition to the mouse retinal OFF pathway

Mazade, R. E., & Eggers, E. D. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00384.2013 · Cited by 22 · see citing works

Variation in Rhodopsin Kinase Expression Alters the Dim Flash Response Shut Off and the Light Adaptation in Rod Photoreceptors

Sakurai, K., Young, J. E., Kefalov, V. J., & Khani, S. C. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7158 · Cited by 21 · see citing works

Topography of Cone Dark Adaptation Deficits in Age‐Related Maculopathy

Gaffney, A. J., Binns, A. M., & Margrain, T. H. (2011) · Optometry and Vision Science · doi:10.1097/opx.0b013e3182223697 · Cited by 21 · see citing works

Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses

Kolesnikov, A. V., & Kefalov, V. J. (2012) · Journal of Visualized Experiments · doi:10.3791/3424 · Cited by 21 · see citing works

Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs

Gao, S., Kahremany, S., Zhang, J., Jastrzębska, B., Querubin, J. R., Petersen‐Jones, S. M., & Palczewski, K. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.111294 · Cited by 21 · see citing works

Diabetic photoreceptors: Mechanisms underlying changes in structure and function

Becker, S., Carroll, L. S., & Vinberg, F. (2020) · Visual Neuroscience · doi:10.1017/s0952523820000097 · Cited by 20 · see citing works

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

Mowat, F. M., Gervais, K. J., Occelli, L. M., Annear, M. J., Querubin, J. R., Bainbridge, J. W., Smith, A. J., Ali, R. R., & Petersen‐Jones, S. M. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-21930 · Cited by 20 · see citing works

Sensory Transduction

Fain, G. (2019) · doi:10.1093/oso/9780198835028.001.0001 · Cited by 22 · see citing works

Function of mammalian M-cones depends on the level of CRALBP in Müller cells

Kolesnikov, A. V., Kiser, P. D., Palczewski, K., & Kefalov, V. J. (2020) · The Journal of General Physiology · doi:10.1085/jgp.202012675 · Cited by 19 · see citing works

An S-Opsin Knock-In Mouse (F81Y) Reveals a Role for the Native Ligand 11-cis-Retinal in Cone Opsin Biosynthesis

Insinna, C., Daniele, L. L., Davis, J. A., Larsen, D. D., Kuemmel, C., Wang, J., Nikonov, S. S., Knox, B. E., & Pugh, E. N. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-12.2012 · Cited by 19 · see citing works

Towards a New Biomarker for Diabetic Retinopathy: Exploring RBP3 Structure and Retinoids Binding for Functional Imaging of Eyes In Vivo

Kaushik, V., Gessa, L., Kumar, N., & Fernandes, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054408 · Cited by 19 · see citing works

Early diabetes impairs ON sustained ganglion cell light responses and adaptation without cell death or dopamine insensitivity

Flood, M. D., Wellington, A. J., Cruz, L. A., & Eggers, E. D. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108223 · Cited by 18 · see citing works

Retinol dehydrogenase 8 and ATP‐binding cassette transporter 4 modulate dark adaptation of M‐cones in mammalian retina

Kolesnikov, A. V., Maeda, A., Tang, P. H., Imanishi, Y., Palczewski, K., & Kefalov, V. J. (2015) · The Journal of Physiology · doi:10.1113/jp271285 · Cited by 18 · see citing works

Retinal regions shape human and murine Müller cell proteome profile and functionality

Kaplan, L., Drexler, C., Pfaller, A. M., Brenna, S., Wunderlich, K. A., Dimitracopoulos, A., Merl‐Pham, J., Perez, M., Schlötzer-Schrehardt, U. M., Enzmann, V., et al. (2022) · Glia · doi:10.1002/glia.24283 · Cited by 17 · see citing works

Interphotoreceptor Retinoid‐Binding Protein Protects Retinoids from Photodegradation

Gonzalez‐Fernandez, F., Betts-Obregon, B. S., Yust, B. G., Mimun, J., Sung, D., Sardar, D. K., & Tsin, A. T. C. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12416 · Cited by 17 · see citing works

Cis-retinoids and the chemistry of vision

Cascella, M., Bärfuss, S., & Stocker, A. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.06.003 · Cited by 16 · see citing works

Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells

Flood, M. D., & Eggers, E. D. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00218.2021 · Cited by 16 · see citing works

Diacylglycerol O-Acyltransferase Type-1 Synthesizes Retinyl Esters in the Retina and Retinal Pigment Epithelium

Kaylor, J. J., Radu, R. A., Bischoff, N., Makshanoff, J., Hu, J. G., Lloyd, M. B., Eddington, S., Bianconi, T., Bok, D., & Travis, G. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125921 · Cited by 16 · see citing works

Different types of retinal inhibition have distinct neurotransmitter release properties

Moore-Dotson, J. M., Klein, J. S., Mazade, R. E., & Eggers, E. D. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00447.2014 · Cited by 14 · see citing works

Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling

Mazade, R. E., & Eggers, E. D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00948.2015 · Cited by 14 · see citing works

RDH12 allows cone photoreceptors to regenerate opsin visual pigments from a chromophore precursor to escape competition with rods

Kaylor, J. J., Frederiksen, R., Bedrosian, C. K., Huang, M., Stennis-Weatherspoon, D., Huynh, T. H., Ngan, T., Mulamreddy, V., Sampath, A. P., Fain, G., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.06.031 · Cited by 13 · see citing works

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

Ward, R. H. R., Sundaramurthi, H., Giacomo, V. D., & Kennedy, B. N. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00037 · Cited by 13 · see citing works

Electrophysiological and microperimetry changes in vitamin A deficiency retinopathy

Saker, S., Morales, M., Jhittay, H., Wen, Y., & Amoaku, W. (2015) · Documenta Ophthalmologica · doi:10.1007/s10633-015-9484-z · Cited by 13 · see citing works

Unusual morphology of foveal Müller glia in an adult human born pre-term

Kar, D., Singireddy, R., Kim, Y. J., PACKER, O. S., Schalek, R. L., Cao, D., Sloan, K. R., Pollreisz, A., Dacey, D. M., & Curcio, C. A. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1409405 · Cited by 11 · see citing works

Clinical applications of retinal gene therapies

Fu, X., Huu, V. A. N., Duan, Y., Kermany, D., Valentim, C. C. S., Zhang, R., Zhu, J., Zhang, C. L., Sun, X., & Zhang, K. (2018) · Precision Clinical Medicine · doi:10.1093/pcmedi/pby004 · Cited by 11 · see citing works

A Comprehensive Study of the Retinal Phenotype of Rpe65-Deficient Dogs

Annear, M. J., Mowat, F. M., Occelli, L. M., Smith, A. J., Curran, P. G., Bainbridge, J. W., Ali, R. R., & Petersen‐Jones, S. M. (2021) · Cells · doi:10.3390/cells10010115 · Cited by 10 · see citing works

Rhodopsin in the rod surface membrane regenerates more rapidly than bulk rhodopsin in the disc membranes in vivo

Kessler, C., Tillman, M., Burns, M. E., & Pugh, E. N. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.272518 · Cited by 10 · see citing works

The Cone-specific visual cycle

Wang, J.-S., & Kefalov, V. J. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.11.001 · Cited by 335 · see citing works

Intra-retinal visual cycle required for rapid and complete cone dark adaptation

Wang, J.-S., Estevez, M. E., Cornwall, M. C., & Kefalov, V. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2258 · Cited by 151 · see citing works

E.: “A Summary of

Wang, J.-S., Estevez, M. E., Cornwall, M. C., & Kefalov, V. J. (1968)

The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently of the Interphotoreceptor Retinoid-Binding Protein

Kolesnikov, A. V., Tang, P. H., Parker, R. O., Crouch, R. K., & Kefalov, V. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0438-11.2011 · Cited by 59 · see citing works

Chromophore Supply Rate-Limits Mammalian Photoreceptor Dark Adaptation

Wang, J., Nymark, S., Frederiksen, R., Stabio, M. E., Shen, S. Q., Corbo, J. C., Cornwall, M. C., & Kefalov, V. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1245-14.2014 · Cited by 28 · see citing works