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Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion
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Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K., & de Lecea, L. (2007) · Nature · doi:10.1038/nature06310 · Cited by 1,341
Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice
Huber, D., Petreanu, L., Ghitani, N., Ranade, S., Hromádka, T., Mainen, Z., & Svoboda, K. (2008) · Nature · doi:10.1038/nature06445 · Cited by 539
V1 spinal neurons regulate the speed of vertebrate locomotor outputs
Gosgnach, S., Lanuza, G. M., Butt, S. J. B., Saueressig, H., Zhang, Y., Velasquez, T., Riethmacher, D., Callaway, E. M., Kiehn, O., & Goulding, M. (2006) · Nature · doi:10.1038/nature04545 · Cited by 405
Self-citation
Research works printed but not linked: 43
- Grillner, S. The motor infrastructure: from ion channels to neuronal networks. Nat. Rev. Neurosci. 4, 573–586 (2003). · DOI
- Feldman, J.L. & Del Negro, C.A. Looking for inspiration: new perspectives on respiratory rhythm. Nat. Rev. Neurosci. 7, 232–242 (2006). · DOI · Paper page
- Kiehn, O. Locomotor circuits in the mammalian spinal cord. Annu. Rev. Neurosci. 29, 279–306 (2006). · DOI
- Dubuc, R. et al. Initiation of locomotion in lampreys. Brain Res. Rev. 57, 172–182 (2008). · DOI
- Jordan, L.M., Liu, J., Hedlund, P.B., Akay, T. & Pearson, K.G. Descending command systems for the initiation of locomotion in mammals. Brain Res. Rev. 57, 183–191 (2008). · DOI · Paper page
- Schmidt, B.J. & Jordan, L.M. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res. Bull. 53, 689–710 (2000). · DOI · Paper page
- Kiehn, O., Kjaerulff, O., Tresch, M.C. & Harris-Warrick, R.M. Contributions of intrinsic motor neuron properties to the production of rhythmic motor output in the mammalian spinal cord. Brain Res. Bull. 53, 649–659 (2000). · DOI
- Nishimaru, H. & Kudo, N. Formation of the central pattern generator for locomotion in the rat and mouse. Brain Res. Bull. 53, 661–669 (2000). · DOI
- Clarac, F., Pearlstein, E., Pflieger, J.F. & Vinay, L. The in vitro neonatal rat spinal cord preparation: a new insight into mammalian locomotor mechanisms. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 190, 343–357 (2004). · DOI
- Kullander, K. et al. Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. Science 299, 1889–1892 (2003). · DOI · Paper page
- Lanuza, G.M., Gosgnach, S., Pierani, A., Jessell, T.M. & Goulding, M. Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron 42, 375–386 (2004). · DOI · Paper page
- Crone, S.A. et al. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron 60, 70–83 (2008). · DOI · Paper page
- Zhang, Y. et al. V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. Neuron 60, 84–96 (2008). · DOI
- Zhang, F., Aravanis, A.M., Adamantidis, A., de Lecea, L. & Deisseroth, K. Circuit-breakers: optical technologies for probing neural signals and systems. Nat. Rev. Neurosci. 8, 577–581 (2007). · DOI · Paper page
- Gradinaru, V., Mogri, M., Thompson, K.R., Henderson, J.M. & Deisseroth, K. Optical deconstruction of parkinsonian neural circuitry. Science 324, 354–359 (2009). · DOI · Paper page
- Pulver, S.R., Pashkovski, S.L., Hornstein, N.J., Garrity, P.A. & Griffith, L.C. Temporal dynamics of neuronal activation by Channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae. J. Neurophysiol. 101, 3075–3088 (2009). · DOI
- Liewald, J.F. et al. Optogenetic analysis of synaptic function. Nat. Methods 5, 895–902 (2008). · DOI
- Douglass, A.D., Kraves, S., Deisseroth, K., Schier, A.F. & Engert, F. Escape behavior elicited by single, channelrhodopsin-2–evoked spikes in zebrafish somatosensory neurons. Curr. Biol. 18, 1133–1137 (2008). · DOI
- Arenkiel, B.R. et al. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron 54, 205–218 (2007). · DOI · Paper page
- Wang, H. et al. High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc. Natl. Acad. Sci. USA 104, 8143–8148 (2007). · DOI
- Fremeau, R.T. Jr. et al. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 31, 247–260 (2001). · DOI
- Fremeau, R.T. Jr., Voglmaier, S., Seal, R.P. & Edwards, R.H. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci. 27, 98–103 (2004). · DOI · Paper page
- Wilson, J.M. et al. Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein. J. Neurosci. 25, 5710–5719 (2005). · DOI
- Lundfald, L. et al. Phenotype of V2-derived interneurons and their relationship to the axon guidance molecule EphA4 in the developing mouse spinal cord. Eur. J. Neurosci. 26, 2989–3002 (2007). · DOI
- Crone, S.A., Zhong, G., Harris-Warrick, R. & Sharma, K. In mice lacking V2a interneurons, gait depends on speed of locomotion. J. Neurosci. 29, 7098–7109 (2009). · DOI · Paper page
- Restrepo, C.E. et al. Transmitter-phenotypes of commissural interneurons in the lumbar spinal cord of newborn mice. J. Comp. Neurol. 517, 177–192 (2009). · DOI
- Nagel, G. et al. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc. Natl. Acad. Sci. USA 100, 13940–13945 (2003). · DOI · Paper page
- Boyden, E.S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat. Neurosci. 8, 1263–1268 (2005). · DOI · Paper page
- Kiehn, O. & Kjaerulff, O. Distribution of central pattern generators for rhythmic motor outputs in the spinal cord of limbed vertebrates. Ann. NY Acad. Sci. 860, 110–129 (1998). · DOI
- Zhong, G., Diaz-Rios, M. & Harris-Warrick, R.M. Serotonin modulates the properties of ascending commissural interneurons in the neonatal mouse spinal cord. J. Neurophysiol. 95, 1545–1555 (2006). · DOI
- Bracci, E., Ballerini, L. & Nistri, A. Spontaneous rhythmic bursts induced by pharmacological block of inhibition in lumbar motoneurons of the neonatal rat spinal cord. J. Neurophysiol. 75, 640–647 (1996). · DOI
- Zaporozhets, E., Cowley, K.C. & Schmidt, B.J. Propriospinal neurons contribute to bulbospinal transmission of the locomotor command signal in the neonatal rat spinal cord. J. Physiol. (Lond.) 572, 443–458 (2006). · DOI
- Reed, W.R., Shum-Siu, A. & Magnuson, D.S. Reticulospinal pathways in the ventrolateral funiculus with terminations in the cervical and lumbar enlargements of the adult rat spinal cord. Neuroscience 151, 505–517 (2008). · DOI
- Liu, J. & Jordan, L.M. Stimulation of the parapyramidal region of the neonatal rat brain stem produces locomotor-like activity involving spinal 5-HT7 and 5-HT2A receptors. J. Neurophysiol. 94, 1392–1404 (2005). · DOI
- Kiehn, O. & Kjaerulff, O. Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J. Neurophysiol. 75, 1472–1482 (1996). · DOI · Paper page
- Aravanis, A.M. et al. An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J. Neural Eng. 4, S143–S156 (2007). · DOI
- McLean, D.L., Masino, M.A., Koh, I.Y., Lindquist, W.B. & Fetcho, J.R. Continuous shifts in the active set of spinal interneurons during changes in locomotor speed. Nat. Neurosci. 11, 1419–1429 (2008). · DOI · Paper page
- Roberts, A., Soffe, S.R., Wolf, E.S., Yoshida, M. & Zhao, F.Y. Central circuits controlling locomotion in young frog tadpoles. Ann. NY Acad. Sci. 860, 19–34 (1998). · DOI
- Magnuson, D.S. & Trinder, T.C. Locomotor rhythm evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord in vitro. J. Neurophysiol. 77, 200–206 (1997). · DOI
- Marchetti, C., Beato, M. & Nistri, A. Alternating rhythmic activity induced by dorsal root stimulation in the neonatal rat spinal cord in vitro. J. Physiol. (Lond.) 530, 105–112 (2001). · DOI
- Bonnot, A., Whelan, P.J., Mentis, G.Z. & O'Donovan, M.J. Locomotor-like activity generated by the neonatal mouse spinal cord. Brain Res. Brain Res. Rev. 40, 141–151 (2002). · DOI
- Stornetta, R.L., Sevigny, C.P. & Guyenet, P.G. Vesicular glutamate transporter DNPI/VGLUT2 mRNA is present in C1 and several other groups of brainstem catecholaminergic neurons. J. Comp. Neurol. 444, 191–206 (2002). · DOI
- Parkitna, J.R., Engblom, D. & Schutz, G. Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes. Methods Mol. Biol. 530, 325–342 (2009). · DOI
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Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
The development and application of optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113817 · Cited by 1,822
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Madisen, L., Mao, T., Koch, H., Zhuo, J.-M., Berenyi, A., Fujisawa, S., Hsu, Y.-W. A., Garcia, A. J., Gu, X., Zanella, S., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3078 · Cited by 1,398
Decoding the organization of spinal circuits that control locomotion
Kiehn, O. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.9 · Cited by 742
Self-citationRestoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury
van den Brand, R., Heutschi, J., Barraud, Q., DiGiovanna, J., Bartholdi, K., Huerlimann, M., Friedli, L., Vollenweider, I., Moraud, E. M., Duis, S., et al. (2012) · Science · doi:10.1126/science.1217416 · Cited by 767
Metadata
- Authors
- Hägglund, M., Borgius, L., Dougherty, K. J., & Kiehn, O.
- Venue
- Nature Neuroscience
- Published
- 2010-01-17
- Volume
- 13
- Issue
- 2
- Pages
- 246-252
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2068467384
- Cited by
- 253
- References
- 7
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
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