The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
Abstract
The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epitope expression. However, recent data suggest that resident microglia may be functionally distinct from bone marrow- or blood-derived phagocytes, which invade the CNS under pathological conditions. During the last few years, research on brain myeloid cells has been markedly changed by the advent of new tools in imaging, genetics and immunology. These methodologies have yielded unexpected results, which challenge the traditional view of brain macrophages. On the basis of these new studies, we differentiate brain myeloid subtypes with regard to their origin, function and fate in the brain and illustrate the divergent features of these cells during neurodegeneration.
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“Many of these cytokines are known to be highly elevated in neurological diseases and/or involved in the recruitment of peripheral immune cells into the CNS under pathological conditions”
From iPSC-derived human microglia-like cells to study neurological diseases (2017) · cites this paper as Prinz et al., 2011
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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
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Self-citationReich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Immune attack: the role of inflammation in Alzheimer disease
Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134
Self-citationDavies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
Metadata
- Authors
- Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M.
- Affiliations
- University Medical Center Freiburg (DE)
- Charité – Universitätsmedizin Berlin (DE)
- University of Chicago (US)
- Cleveland Clinic (US)
- Corresponding author
- Prinz, Marco
- Ransohoff, Richard M
- Venue
- Nature Neuroscience
- Published
- 2011-09-27
- Volume
- 14
- Issue
- 10
- Pages
- 1227-1235
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2071753918
- Cited by
- 674
- References
- 102
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 33 · 2023: 29 · 2022: 37 · 2021: 42 · 2020: 54 · 2019: 39 · 2018: 50 · 2017: 52 · 2016: 64 · 2015: 60 · 2014: 59 · 2013: 65 · 2012: 46
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microglia, meningeal macrophages, perivascular macrophages, neurodegeneration, myeloid cell heterogeneity, phagocytes, brain macrophages
- MeSH terms
- Animals, Brain Diseases, Cell Differentiation, Central Nervous System, Humans, Models, Biological, Nerve Degeneration, Signal Transduction, Microglia, Myeloid Cells
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