Cited by 674Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

Prinz, Marco, Priller, Josef, Sisodia, Sangram S, Ransohoff, Richard M·2011·Nature Neuroscience

DOI 10.1038/nn.2923

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Abstract

The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epitope expression. However, recent data suggest that resident microglia may be functionally distinct from bone marrow- or blood-derived phagocytes, which invade the CNS under pathological conditions. During the last few years, research on brain myeloid cells has been markedly changed by the advent of new tools in imaging, genetics and immunology. These methodologies have yielded unexpected results, which challenge the traditional view of brain macrophages. On the basis of these new studies, we differentiate brain myeloid subtypes with regard to their origin, function and fate in the brain and illustrate the divergent features of these cells during neurodegeneration.

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898
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Multiple sclerosis
Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Immune attack: the role of inflammation in Alzheimer disease
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Self-citation
Tissue-resident macrophages
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096

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Authors: Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M.
Affiliations: University Medical Center Freiburg (DE)
Charité – Universitätsmedizin Berlin (DE)
University of Chicago (US)
Cleveland Clinic (US)
Corresponding author: Prinz, Marco
Ransohoff, Richard M
ORCID: Prinz, Marco
Priller, Josef
Sisodia, Sangram S
Ransohoff, Richard M
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2011-09-27
Volume: 14
Issue: 10
Pages: 1227-1235
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.2923
OpenAlex: W2071753918
Cited by: 674
References: 102
Citations by year: 2026: 17 · 2025: 23 · 2024: 33 · 2023: 29 · 2022: 37 · 2021: 42 · 2020: 54 · 2019: 39 · 2018: 50 · 2017: 52 · 2016: 64 · 2015: 60 · 2014: 59 · 2013: 65 · 2012: 46
FWCI: 4.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: microglia, meningeal macrophages, perivascular macrophages, neurodegeneration, myeloid cell heterogeneity, phagocytes, brain macrophages
MeSH terms: Animals, Brain Diseases, Cell Differentiation, Central Nervous System, Humans, Models, Biological, Nerve Degeneration, Signal Transduction, Microglia, Myeloid Cells

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

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