Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice.
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The stability of dendritic spines in the neocortex is profoundly influenced by sensory experience, which determines the magnitude and pattern of neural firing. By optically manipulating the temporal structure of neural activity in vivo using channelrhodopsin-2 and repeatedly imaging dendritic spines along these stimulated neurons over a period of weeks, we show that the specific pattern, rather than the total amount of activity, determines spine stability in awake mice.
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The pattern of neural activity, rather than the magnitude, determines the stability of dendritic spines.
“Recently, an elegant study combining optogenetic stimulation and in vivo imaging showed that it is the pattern of neural activity, rather than the magnitude, that determines the stability of dendritic spines (Wyatt et al., 2012).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Wyatt et al., 2012
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- Authors
- Wyatt, R. M., Tring, E., & Trachtenberg, J. T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Trachtenberg, Joshua T
- Venue
- Nature Neuroscience
- Published
- 2012-06-17
- Volume
- 15
- Issue
- 7
- Pages
- 949-951
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3386353
- OpenAlex
- W1994082182
- Cited by
- 22
- References
- 22
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH077972, MH077972)
- National Eye Institute (EY016052, R01EY016052, R01EY023871)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neural activity patterns, spike timing, cortical pyramidal neurons, neocortex, sensory experience, channelrhodopsin-2, optogenetic stimulation, in vivo imaging, synaptic plasticity, awake mice
- MeSH terms
- Channelrhodopsins, Action Potentials, Amygdala, Animals, Mice, Transgenic, Neural Pathways, Sensory Receptor Cells, Wakefulness, Neocortex, Dendritic Spines, Mice
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