Cited by 585Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Dendritic spine pathology in schizophrenia

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Glausier, J.R., Lewis, D.A.·2013·Neuroscience

Abstract

Schizophrenia is a neurodevelopmental disorder whose clinical features include impairments in perception, cognition and motivation. These impairments reflect alterations in neuronal circuitry within and across multiple brain regions that are due, at least in part, to deficits in dendritic spines, the site of most excitatory synaptic connections. Dendritic spine alterations have been identified in multiple brain regions in schizophrenia, but are best characterized in layer 3 of the neocortex, where pyramidal cell spine density is lower. These spine deficits appear to arise during development, and thus are likely the result of disturbances in the molecular mechanisms that underlie spine formation, pruning, and/or maintenance. Each of these mechanisms may provide insight into novel therapeutic targets for preventing or repairing the alterations in neural circuitry that mediate the debilitating symptoms of schizophrenia.

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Crossref · 10.1016/j.neuroscience.2012.04.044

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  1. Arnsten AF Paspalas CD Gamo NJ Yang Y Wang M Dynamic Network Connectivity: A new form of neuroplasticity Trends Cogn Sci 2010b 14 365 375 20554470 PMC2914830
  2. Deo AJ Cahill ME Li S Goldszer I Henteleff R VanLeeuwen JE Rafalovich I Gao R Stachowski EK Sampson AR Lewis DA Penzes P Sweet RA Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: Its role in dendritic pathology Neurobiol Dis 2011b PMC3259283 22120753
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Authors
Glausier, J. R., & Lewis, D. A.
Affiliations
University of Pittsburgh (US)
Corresponding author
Lewis, D.A.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2013-10
Volume
251
Pages
90-107
ISSN
0306-4522 (ISSN-L)
OpenAlex
W1997950587
Cited by
581
References
248
Citations by year
2026: 29 · 2025: 37 · 2024: 43 · 2023: 52 · 2022: 50 · 2021: 48 · 2020: 55 · 2019: 42 · 2018: 43 · 2017: 43 · 2016: 42 · 2015: 48 · 2014: 32 · 2013: 12 · 2012: 4
FWCI
4.13
Type
journal article
Language
en
Open access
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (P50MH084053, MH084053, R01MH043784, MH043784)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
schizophrenia, dendritic spines, synaptic dysfunction, pyramidal neurons, synaptic pruning, neural circuits, brain development, therapeutic target
MeSH terms
Humans, Schizophrenia, Pyramidal Cells, Neocortex, Dendritic Spines

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