Cited by 85Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Synapse rearrangements upon learning: from divergent–sparse connectivity to dedicated sub-circuits

Caroni, Pico, Chowdhury, Ananya, Lahr, Maria·2014·Trends in Neurosciences

Abstract

Learning can involve formation of new synapses and loss of synapses, providing memory traces of learned skills. Recent findings suggest that these synapse rearrangements reflect assembly of task-related sub-circuits from initially broadly distributed and sparse connectivity in the brain. These local circuit remodeling processes involve rapid emergence of synapses upon learning, followed by protracted validation involving strengthening of some new synapses, and selective elimination of others. The timing of these consolidation processes can vary. Here, we review these findings, focusing on how molecular/cellular mechanisms of synapse assembly, strengthening, and elimination might interface with circuit/system mechanisms of learning and memory consolidation. An integrated understanding of these learning-related processes should provide a better basis to elucidate how experience, genetic background, and disease influence brain function.

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Crossref · 10.1016/j.tins.2014.08.011

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  • Reelin signaling activates PI3kinase, which initiates a pathway that induces phosphorylation of LIM kinase-1 (LIMK-1), which in turn phosphorylates cofilin at an inhibitory site, blocking the actin-depolymerizing activity of cofilin.

    “Reelin signaling activates PI3kinase, as described above [61]. In turn, PI3kinase initiates a signaling pathway that induces phosphorylation of LIM kinase-1 (LIMK-1), which in turn phosphorylates cofilin at an inhibitory site, blocking the actin-depolymerizing activity of cofilin [62, 63].”

    From ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease (2017) · cites this paper as [62]

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Authors
Caroni, P., Chowdhury, A., & Lahr, M.
Affiliations
Friedrich Miescher Institute (CH)
Corresponding author
Caroni, Pico
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2014-10
Volume
37
Issue
10
Pages
604-614
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2012140908
Cited by
85
References
155
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 15 · 2017: 11 · 2016: 10 · 2015: 12
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Novartis Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
synaptic plasticity, synaptic pruning, synaptogenesis, memory consolidation, sparse connectivity, learning, memory traces
MeSH terms
Animals, Brain, Humans, Learning, Memory, Nerve Net, Neuronal Plasticity, Synapses

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