Cited by 322Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Subcortical origins of human and monkey neocortical interneurons

Ma, Tong, Wang, Congmin, Wang, Lei, Zhou, Xing, Tian, Miao, Zhang, Qiangqiang, Zhang, Yue, Li, Jiwen, Liu, Zhidong, Cai, Yuqun, Liu, Fang, You, Yan, Chen, Chao, Campbell, Kenneth, Song, Hongjun, Ma, Lan, Rubenstein, John L, Yang, Zhengang·2013·Nature Neuroscience

DOI 10.1038/nn.3536

Open this paper in CoChat — free account

Abstract

Cortical GABAergic inhibitory interneurons have crucial roles in the development and function of the cerebral cortex. In rodents, nearly all neocortical interneurons are generated from the subcortical ganglionic eminences. In humans and nonhuman primates, however, the developmental origin of neocortical GABAergic interneurons remains unclear. Here we show that the expression patterns of several key transcription factors in the developing primate telencephalon are very similar to those in rodents, delineating the three main subcortical progenitor domains (the medial, lateral and caudal ganglionic eminences) and the interneurons tangentially migrating from them. On the basis of the continuity of Sox6, COUP-TFII and Sp8 transcription factor expression and evidence from cell migration and cell fate analyses, we propose that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon. Our findings reveal that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping our understanding of the origin and classification of primate neocortical interneurons.

Integrity signals

Registry

Crossref · 10.1038/nn.3536

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Self-citation
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
Spatio-temporal transcriptome of the human brain
Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature · doi:10.1038/nature10523 · Cited by 2,084
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420
Neurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342
Interneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190
The origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873
Self-citation
Corridors of migrating neurons in the human brain and their decline during infancy
Sanai, N., Nguyen, T., Ihrie, R. A., Mirzadeh, Z., Tsai, H.-H., Wong, M., Gupta, N., Berger, M. S., Huang, E., Garcia-Verdugo, J.-M., et al. (2011) · Nature · doi:10.1038/nature10487 · Cited by 849

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 201–300 of 322

Anin vitromodel of human neocortical development using pluripotent stem cells: cocaine-induced cytoarchitectural alterations
Kindberg, A. A., Bendriem, R. M., Spivak, C. E., Chen, J., Handreck, A., Lupica, C. R., Liu, J., Freed, W. J., & Lee, C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.017251 · Cited by 14
Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex
Viswanadham, V., Kim, S. N., Caglayan, E., Doan, R. N., Dou, Y., Bizzotto, S., Khoshkhoo, S., Huang, A. Y., Yeh, R. C., Chhouk, B. H., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116458 · Cited by 40
Fate plasticity of interneuron specification
Mostajo-Radji, M. A., Mancia, W., Breevoort, A., Gonzalez-Ferrer, J., Schweiger, H. E., Lehrer, J., Zhou, L., Schmitz, M. T., Perez, Y., Mukhtar, T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112295 · Cited by 9
Developmental dynamics of marmoset prefrontal cortical SST and PV interneuron networks highlight primate-specific features
Fin, N. A. S. H., Yip, A., Scott, J. T., Teo, L., Homman‐Ludiye, J., & Bourne, J. A. (2025) · Development · doi:10.1242/dev.204254 · Cited by 14
An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains
Kim, J. Y., Poddar, A., Sandoval, K., Chu, J. S. F., Horton, E. C., Cui, D., Nakamura, K. C., Lu, I.-L., Mui, M. H., Bartels, T., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01987-2 · Cited by 13
Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains
Feng, X., Gao, Y., Chu, F., Shan, Y., Liu, M., Wang, Y.-Y., Zhu, Y., Lu, Q. R., & Li, M. (2025) · Nature Communications · doi:10.1038/s41467-025-56058-8 · Cited by 10
Transcriptomic and morphologic vascular aberrations underlying FCDIIb etiology
Fang, C., Zhang, X., Yang, L., Sun, L., Lu, Y., Liu, Y., Guo, J., Wang, M., Tan, Y., Zhang, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58535-6 · Cited by 11
The production and functions of caudal ganglionic eminence-derived inhibitory neurons
Horton, E. C., & Paredes, M. F. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.06.007 · Cited by 9
Using the Optical Fractionator to Estimate Total Cell Numbers in the Normal and Abnormal Developing Human Forebrain
Larsen, K. B. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00112 · Cited by 9
Migratory cortical interneuron-specific transcriptome abnormalities in schizophrenia
Park, J. M., Liu, D., Park, G.-H., Noh, H., Ni, P., Yin, C., Huang, W., & Chung, S. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.054 · Cited by 9
Self-tuition as an essential design feature of the brain
Leopold, D. A., & Averbeck, B. B. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0530 · Cited by 9
Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models
Bigarreau, J., Rouach, N., Perrier, A. L., Mouthon, F., & Charvériat, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031684 · Cited by 10
Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion
Yang, Y., Booker, S. A., Clegg, J. M., Urzainqui, I. Q., Sumera, A., Kozić, Z., Dando, O., Lorenzo, S. M., Hérault, Y., Kind, P. C., et al. (2023) · BMC Neuroscience · doi:10.1186/s12868-022-00771-3 · Cited by 9
Cortical interneurons: fit for function and fit to function? Evidence from development and evolution
Keijser, J., & Sprekeler, H. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1172464 · Cited by 9
Transcriptome and in Vitro Differentiation Profile of Human Embryonic Stem Cell Derived NKX2.1-Positive Neural Progenitors
Chen, C. Y., Plocik, A. M., Anderson, N. C., Moakley, D. F., Boyi, T., Dundes, C. E., Lassiter, C. M., Graveley, B. R., & Grabel, L. B. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9676-2 · Cited by 8
Self-citation
Using organoids to study human brain development and evolution
Chan, W. K., Fetit, R., Griffiths, R., Marshall, H., Mason, J. O., & Price, D. J. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22819 · Cited by 8
Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly
Currey, L., Harvey, T. J., Pelenyi, A., Piper, M., & Thor, S. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1586550 · Cited by 8
Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques
Gray, D. T., Peña, N. M. D. L., Umapathy, L., Burke, S. N., Engle, J. R., Trouard, T. P., & Barnes, C. A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1163-20.2020 · Cited by 7
Seeking clues in brain development to explain the extraordinary evolution of language in humans
Clowry, G. J. (2014) · Language Sciences · doi:10.1016/j.langsci.2014.06.014 · Cited by 8
Overview of the Development of the Human Brain and Spinal Cord
ten Donkelaar, H. J., Takakuwa, T., Vasung, L., Yamada, S., Shiota, K., & van der Vliet, T. (2023) · Springer eBooks · doi:10.1007/978-3-031-26098-8_1 · Cited by 8
De novo variants in SP9 cause a novel form of interneuronopathy characterized by intellectual disability, autism spectrum disorder, and epilepsy with variable expressivity
Tessarech, M., Friocourt, G., Marguet, F., Lecointre, M., Mao, M. L., Díaz, R. M., Mignot, C., Keren, B., Héron, B., de Bie, C., et al. (2024) · Genetics in Medicine · doi:10.1016/j.gim.2024.101087 · Cited by 7
S p8 expression in putative neural progenitor cells in guinea pig and human cerebrum
Zhang, X., Cai, Y., Wang, F., Wu, J., Mo, L., Zhang, F., Patrylo, P. R., Pan, A., Ma, C., Fu, J. X., et al. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22367 · Cited by 7
Self-citation
Neuronal density and expression of calcium‐binding proteins across the layers of the superior colliculus in the common marmoset (Callithrix jacchus)
Chong, M. H. Y., Worthy, K. H., Rosa, M. G. P., & Atapour, N. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25388 · Cited by 6
A comparative view of human and mouse telencephalon inhibitory neuron development
Chung, C., Girgiss, J., & Gleeson, J. G. (2025) · Development · doi:10.1242/dev.204306 · Cited by 6
Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei
Alhesain, M., Alzu’bi, A., Sankar, N., Smith, C. J., Kerwin, J. M., Laws, R., Lindsay, S., & Clowry, G. J. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1530236 · Cited by 6
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"
Karimy, J. K., Newville, J., Sadegh, C., Morris, J. A., Monuki, E. S., Limbrick, D. D., McAllister, J. P., Koschnitzky, J. E., Lehtinen, M. K., & Jantzie, L. L. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00406-7 · Cited by 6
Pathogenesis of Germinal Matrix Hemorrhage: Insights from Single-Cell Transcriptomics
Chen, J., Choi, J. J.-Y., Lin, P.-Y., & Huang, E. J. (2024) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-111523-023446 · Cited by 6
A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamusPreprint
Aivazidis, A., Memi, F., Rademaker, K., Koko, M., Roberts, K., Trinh, A. L., Petryszak, R., Kleshchevnikov, V., Tuck, E. J., Lisgo, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.05.685843 · Cited by 6
Maturational Changes of Gamma-Aminobutyric Acid A Receptors Measured With Benzodiazepine Binding of Iodine 123 Iomazenil Single-Photon Emission Computed Tomography
Ikemoto, S., Hamano, S., Hirata, Y., Matsuura, R., & Kikuchi, K. (2018) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2018.02.008 · Cited by 5
Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics
Koch, N. A., Corrigan, B. W., Feyerabend, M., Gulli, R. A., Jimenez-Sosa, M. S., Abbass, M., Sunstrum, J. K., Matovic, S., Roussy, M. P., Luna, R., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115159 · Cited by 6
Transcriptional Regulation of Cortical Interneuron Development
Pai, E. L.-L., Vogt, D. L., Hu, J. S., & Rubenstein, J. L. R. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0047 · Cited by 6
Self-citation
Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques
Gray, D. T., Umapathy, L., Peña, N. M. D. L., Burke, S. N., Engle, J. R., Trouard, T. P., & Barnes, C. A. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz275 · Cited by 7
Gray Matter Lesions
Bigio, M. R. D. (2018) · Wiley eBooks · doi:10.1002/9781119013112.ch22 · Cited by 5
Molecular diversity and lineage commitment of human interneuron progenitorsPreprint
Velmeshev, D., Chavali, M., Nowakowski, T. J., Bhade, M., Mayer, S., Goyal, N., Alvarado, B., Mancia, W., Wang, S., Speir, M. L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.13.444045 · Cited by 5
Human cerebral organoids: Complex, versatile, and human-relevant models of neural development and brain diseases
Coronel, R., González-Sastre, R., Mateos-Martínez, P., Maeso, L., Llorente-Beneyto, E., Martín-Benito, S., Gagosian, V. S. C., Foti, L., González, M. D. C., López-Alonso, V., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01639 · Cited by 5
A selective defect in the glial wedge as part of the neuroepithelium disruption in hydrocephalus development in the mouse hyh model is associated with complete corpus callosum dysgenesis
Rodríguez‐Pérez, L., Sebastian, J. L., de Diego, I., Smith‐Fernández, A., Roales‐Buján, R., Jimenez, A. J., & Páez, P. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1330412 · Cited by 4
An interneuron progenitor maintains neurogenic potential in vivo and differentiates into GABAergic interneurons after transplantation in the postnatal rat brain
Wang, Q., Hong, P., Gao, H., Chen, Y., Yang, Q., Jiang, M. H., & Li, H. (2016) · Scientific Reports · doi:10.1038/srep19003 · Cited by 5
Functional maturation of neocortical inhibitory interneurons
Larimer, P., & Hasenstaub, A. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00019-3 · Cited by 5
Distinct developmental growth patterns account for the disproportionate expansion of the rostral and caudal isocortex in evolution
Charvet, C. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00190 · Cited by 4
Fused dorsal-ventral cerebral organoids model human cortical interneuron migrationPreprint
Bagley, J. A., Reumann, D., Bian, S., & Knoblich, J. A. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/131250 · Cited by 3
Human cortical interneuron development unraveled
Kessaris, N. (2022) · Science · doi:10.1126/science.abn6333 · Cited by 4
Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior
Boroujeni, K. B., Balaram, P., Tiesinga, P. H. E., & Womelsdorf, T. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102873 · Cited by 4
Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain
Jia, L., Li, X., Yan, Y., Xu, L., Guo, J., Wang, W., Zhang, W., Li, L., Shang, B., Zhang, Y., et al. (2026) · Science · doi:10.1126/science.adw1803 · Cited by 4
Self-citation
Tyrosine hydroxylase-producing neurons in the human cerebral cortex do not colocalize with calcium-binding proteins or the serotonin 3A receptor
Asmus, S. E., Raghanti, M. A., Beyerle, E. R., Fleming-Beattie, J. C., Hawkins, S. M., McKernan, C., & Rauh, N. A. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.07.007 · Cited by 3
Expression of the schizophrenia associated gene FEZ1 in the early developing fetal human forebrain
Alhesain, M., Ronan, H., LeBeau, F. E. N., & Clowry, G. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1249973 · Cited by 3
Development of the Central Nervous System
Catala, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-31512-6_1-1 · Cited by 4
Cortical interneurons: fit for function and fit to function? Evidence from development and evolutionPreprint
Keijser, J., & Sprekeler, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.23.529671 · Cited by 3
The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of NeuroblastsPreprint
Kim, J., Sandoval, K., Poddar, A., Chu, J. S. F., Horton, E. C., Cui, D., Nakamura, K. C., Bartels, T., Wood, C. M., Rowitch, D. H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.06.543768 · Cited by 3
Developmental dynamics of the prefrontal cortical SST and PV interneuron networks: Insights from the monkey highlight human-specific featuresPreprint
Fin, N. A. S. H., Yip, A., Teo, L., Homman‐Ludiye, J., & Bourne, J. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.10.602904 · Cited by 3
Neocortical neurogenesis: a proneural gene perspective
Vasan, L., Moffat, A., Mattar, P. A., & Schuurmans, C. (2025) · FEBS Journal · doi:10.1111/febs.70158 · Cited by 3
Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex
Li, J., Yang, F., Li, W., Fu, T., Li, Z., Sha, Z., Zheng, W., Yang, C., Yu, J., Han, D., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-10366-x · Cited by 2
Self-citation
Development and Developmental Disorders of the Cerebral Cortex
ten Donkelaar, H. J., Vasung, L., Molnár, Z., Aronica, E., Lammens, M. M. Y., van Bokhoven, H., Ulzen, K. K.-V., & Hori, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-26098-8_10 · Cited by 3
Advances in the use of GABAergic interneurons for the treatment of epilepsy
Frisina, F., Valetti, G., Zuccarini, G., Conti, L., & Merlo, G. R. (2019) · Journal of Stem Cell Therapy and Transplantation · doi:10.29328/journal.jsctt.1001014 · Cited by 2
Characterization and Stage-Dependent Lineage Analysis of Intermediate Progenitors of Cortical GABAergic Interneurons
Esumi, S., Nasu, M., Kawauchi, T., Miike, K., Morooka, K., Yanagawa, Y., Seki, T., Sakimura, K., Fukuda, T., & Tamamaki, N. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.607908 · Cited by 2
Tracing interneuron roots
Whalley, K. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3628 · Cited by 2
Prenatal betamethasone does not affect glutamatergic or GABAergic neurogenesis in preterm newborns
Vose, L. R., Vinukonda, G., Diamond, D., Korumilli, R., Hu, F., Zia, M., Hevner, R. F., & Ballabh, P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.009 · Cited by 2
Hedgehog Promotes Production of Inhibitory Interneurons in Vivo and in Vitro from Pluripotent Stem Cells
Anderson, N. C., Chen, C. Y., & Grabel, L. B. (2016) · Journal of Developmental Biology · doi:10.3390/jdb4030026 · Cited by 3
Self-citation
Hemorrhagic Lesions
Bigio, M. R. D. (2018) · Wiley eBooks · doi:10.1002/9781119013112.ch20 · Cited by 2
GABAergic neuron dysregulation in a human neurodevelopmental model for major psychiatric disordersPreprint
Guo, Z., Su, Y., Huang, W., Yao, X. S., Hong, Y., Gordin-Kivity, A., Nguyen, H. N., Wen, Z., Rojas, F., Gong, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614564 · Cited by 3
Self-citation
Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal GangliaPreprint
Siebert, C., Song, M., Moriano, J., Li, Z., Cebrián‐Silla, A., Walker, M., Chen, S., Baltazar, J., de Oliveira, L. G., Shankar, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.31.697063 · Cited by 3
Self-citation
Fusion of single-cell transcriptome and DNA-binding data, for genomic network inference in cortical development
Bartlett, T. E. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04201-9 · Cited by 1
Preferential transduction of parvalbumin-expressing cortical neurons by AAV-mDLX5/6 vectors
Yazdan-Shahmorad, P., Gibson, S. D., Lee, J. C., & Horwitz, G. D. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1269025 · Cited by 1
Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices
Tsolias, A., Mojica, C. A., Yamani, R., Khanna, S., Abdullatif, S. A., Snyder, B. J., Chang, W., Guillamón-Vivancos, T., Goodliffe, J. W., Capriglione, A. L., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09866-7 · Cited by 1
A pipeline for cell migration analysis in live-cell imaging data from human iPSC-derived forebrain assembloids
Weidman, M. P., Campbell, N. B., Headings, C., Chung, S., Khan, M., Kandukuri, A., Lim, V., Olubowale, G., Kim, M. J., Devor, A., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1880548 · Cited by 2
Development and Developmental Disorders of the Forebrain
ten Donkelaar, H. J., Lammens, M. M. Y., Cruysberg, J. R. M., Ulzen, K. K.-V., Hori, A., Shiota, K., Itoh, K., & Willemsen, M. A. A. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-26098-8_9 · Cited by 2
Epigenetics in Child Psychiatry
Elia, J., Kingsley, R. S., Yost, O., Bongiorno, C., Bernacki, C. G., Ambrosini, A. P., Okuyama, M., & Hakonarson, H. H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00020-6 · Cited by 1
Modeling Down Syndrome Neurodevelopment with Dosage Compensation
Czerminski, J. T. (2019) · eScholarship@UMassChan · doi:10.13028/j7xf-1q21 · Cited by 1
Current progress in brain organoid technology
Wei, P. A. N. G., YanTong, L. I. U., & Xiang, Y. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0278 · Cited by 1
An interface of genetically engineered human forebrain assembloids and polymeric nanofiber scaffolds for multiscale profiling of interneuron migration disordersPreprint
Rauthan, R., Bharti, V., Agashe, A., Singh, P., York, H. M., Nain, A. S., Arumugam, S., & Chakraborty, D. (2024) · Research Square · doi:10.21203/rs.3.rs-3831019/v1 · Cited by 1
Human brains teach us a surprising lesson
McKenzie, M. G., & Fishell, G. (2016) · Science · doi:10.1126/science.aai9379
Telencephalic Tissue Formation in 3D Stem Cell Culture
Kadoshima, T., Sakaguchi, H., & Eiraku, M. (2017) · Springer eBooks · doi:10.1007/978-981-10-3768-9_1
Development of the Central Nervous System
Catala, M. (2020) · Springer eBooks · doi:10.1007/978-3-319-72168-2_1
Brain organoids as a model system for human neurodevelopment in health and disease
Reiner, O., & Karzbrun, E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00010-2
Generation and characterisation of human cortical interneurons reporter stem cell lines
Santos, C., & de la Concepción, M. L. R. (2019) · ORCA Online Research @Cardiff (Cardiff University)
From human pluripotent stem cells to cerebral cortical neurons
Deleanu, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822230-0.00013-2
Fusion of single-cell transcriptome and DNA-binding data, for genomic network inference in cortical developmentPreprint
Bartlett, T. E. (2021) · BMC Bioinformatics · doi:10.1101/2021.05.18.444638 · Cited by 2
c-Jun NH2-terminal kinase signaling controls cellular mechanisms of guided cortical interneuron migration
Smith, S. E. (2020) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.7976
Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrainPreprint
Yang, Y., Booker, S. A., Clegg, J. M., Urzainqui, I. Q., Sumera, A., Kozić, Z., Dando, O., Lorenzo, S. M., Hérault, Y., Kind, P. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.03.446920
The Importance of Studying Human Brain
Jakovcevski, M., Mitrović, S., & Jakovčevski, I. (2021) · Serbian Journal of Experimental and Clinical Research · doi:10.2478/sjecr-2020-0065 · Cited by 1
The construction of 3D cognitive networks from iPSCs through precise spatiotemporal specification
Miu, K.-K., Cao, D., Wang, Z., Hao, S., & Chan, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823809-7.00012-8
Faculty Opinions recommendation of Conserved cell types with divergent features in human versus mouse cortex.
Tiwari, V. K., & Singh, A. P. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736463800.793571577
Cerebral Cortex, Including Germinal Matrix
Bigio, M. R. D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781316671863.021
Epigenetics in child psychiatry
Elia, J., Izaki, Y., Borreggine, K. L., Yost, O., Castro, A., Chang, C. Y., Ambrosini, A. P., Fels, S., Poddar, K., Rayfield, J., et al. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00012-x
Faculty Opinions recommendation of Generation and assembly of human brain region-specific three-dimensional cultures.
Muotri, A. R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733994888.793560520
Radial migration in the developing cerebral cortex
Noctor, S. C., Cunningham, C. L., & Kriegstein, A. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00015-8 · Cited by 2
Faculty Opinions recommendation of Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.
Weiner, J. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734891244.793556605
Faculty Opinions recommendation of Self-organized developmental patterning and differentiation in cerebral organoids.
Muotri, A. R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727390956.793560518
C-Jun N-Terminal Kinase Signaling Guides the Migration of Interneurons During Cortical Development
Myers, A. (2017) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6285
Faculty Opinions recommendation of hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.
Muotri, A. R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735150559.793560524
Neurodevelopment
Zilles, K., & Palomero‐Gallagher, N. (2020) · doi:10.1093/med/9780198713005.003.0011
Faculty Opinions recommendation of Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.
Herrera, E., & Escalante, A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732279312.793579530
Generation of Homogeneous Populations of Cortical Interneurons from Human Pluripotent Stem Cells
Ni, P., Fan, L., Zinski, A. L., & Chung, S. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3287-1_2
Cortical Neuron Migration in Health and Disease
Javier‐Torrent, M., & Nguyen, L. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch17
Brain cell types and distribution
Kooijmans, R. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00198-4
The Development of the Central Nervous System and Human Neural Stem Cells
Ávila, A., Ascenzi, B. M., & Vidal, P. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-822404-5.00001-2
Development of the Hippocampal Formation
Lavenex, P., Amaral, D. G., Lavenex, P. B., Guillemot, F., Insausti, R., & Urbán, N. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0004
Bringing Chandelier Cells Out of the Shadows: Exploring the Development of a Unique Neuron Type in the BrainPreprint
Lenherr, C., Neves, G., Oliveira, M. G., & Burrone, J. (2025) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041506
Additional file 1 of Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion
Yang, Y., Booker, S. A., Clegg, J. M., Urzainqui, I. Q., Sumera, A., Kozić, Z., Dando, O., Lorenzo, S. M., Hérault, Y., Kind, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26562655
Additional file 4 of Prenatal alcohol exposure is a leading cause of interneuronopathy in humans
Marguet, F., Friocourt, G., Brosolo, M., Sauvestre, F., Marcorelles, P., Lesueur, C., Marret, S., Gonzalez, B. J., & Laquerrière, A. (2020) · Figshare · doi:10.6084/m9.figshare.13310404
Additional file 1 of Fusion of single-cell transcriptome and DNA-binding data, for genomic network inference in cortical development
Bartlett, T. E. (2021) · Figshare · doi:10.6084/m9.figshare.14736948

Authors: Ma, T., Wang, C., Wang, L., Zhou, X., Tian, M., Zhang, Q., Zhang, Y., Li, J., Liu, Z., Cai, Y., Liu, F., You, Y., Chen, C., Campbell, K., Song, H., Ma, L., Rubenstein, J. L., & Yang, Z.
Affiliations: Fudan University (CN)
Shanghai Medical College of Fudan University (CN)
Hebei Medical University (CN)
Children's Hospital of Fudan University (CN)
Cincinnati Children's Hospital Medical Center (US)
Johns Hopkins University (US)
University of California, San Francisco (US)
Corresponding author: Yang, Zhengang
ORCID: Wang, Lei
Zhou, Xing
Zhang, Qiangqiang
Zhang, Yue
Li, Jiwen
Liu, Zhidong
Liu, Fang
You, Yan
Campbell, Kenneth
Song, Hongjun
Ma, Lan
Rubenstein, John L
Yang, Zhengang
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2013-10-06
Volume: 16
Issue: 11
Pages: 1588-1597
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3536
OpenAlex: W2085806268
Cited by: 322
References: 50
Citations by year: 2026: 17 · 2025: 22 · 2024: 19 · 2023: 27 · 2022: 23 · 2021: 33 · 2020: 31 · 2019: 28 · 2018: 19 · 2017: 27 · 2016: 21 · 2015: 21 · 2014: 31 · 2013: 3
FWCI: 9.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Chinese Academy of Sciences
Fudan University
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: neocortical interneurons, GABAergic interneurons, ganglionic eminence, transcription factors, SOX6, COUP-TFII, Sp8, tangential migration, human brain development, ventral telencephalon
MeSH terms: Adult, Age Factors, Animals, Animals, Newborn, Bromodeoxyuridine, Cell Count, Cell Movement, Cells, Cultured, Embryo, Mammalian, gamma-Aminobutyric Acid, Humans, Interneurons, Macaca mulatta, Male, Nerve Tissue Proteins, Organ Culture Techniques, Transcription Factors, Transfection, Gene Expression Regulation, Developmental, Neocortex, Green Fluorescent Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Subcortical origins of human and monkey neocortical interneurons

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks