Cited by 561Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchMemory and Neural Mechanisms

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

Open access

Khan, Usman A, Liu, Li, Provenzano, Frank A, Berman, Diego E, Profaci, Caterina P, Sloan, Richard, Mayeux, Richard, Duff, Karen E, Small, Scott A·2014·Nature Neuroscience

DOI 10.1038/nn.3606PMC PMC4044925

Open this paper in CoChat — free account

Abstract

The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects in patients and mouse models to address basic questions about entorhinal cortex pathophysiology. The entorhinal cortex is divided into functionally distinct regions, the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC), and we exploited the high-resolution capabilities of the fMRI variant to ask whether either of them was affected in patients with preclinical Alzheimer's disease. Next, we imaged three mouse models of disease to clarify how tau and APP relate to entorhinal cortex dysfunction and to determine whether the entorhinal cortex can act as a source of dysfunction observed in other cortical areas. We found that the LEC was affected in preclinical disease, that LEC dysfunction could spread to the parietal cortex during preclinical disease and that APP expression potentiated tau toxicity in driving LEC dysfunction, thereby helping to explain regional vulnerability in the disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nn.3606

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
N4ITK: Improved N3 Bias Correction
Tustison, N. J., Avants, B., Cook, P. A., Zheng, Y., Egan, A., Yushkevich, P. A., & Gee, J. C. (2010) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2010.2046908 · Cited by 6,413
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Show all 60 references

Research works printed but not linked: 2

Kageyama, G.H. & Wong-Riley, M.T. Histochemical localization of cytochrome oxidase in the hippocampus: correlation with specific neuronal types and afferent pathways. Neuroscience 7, 2337–2361 (1982). · DOI
Moreno, H., Hua, F., Brown, T. & Small, S. Longitudinal mapping of mouse cerebral blood volume with MRI. NMR Biomed. 19, 535–543 (2006). · DOI

Sorted by citations

The Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990
Brain atrophy in Alzheimer’s Disease and aging
Pini, L., Pievani, M., Bocchetta, M., Altomare, D., Bosco, P., Cavedo, E., Galluzzi, S., Marizzoni, M., & Frisoni, G. B. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.002 · Cited by 836
Tau and neurodegenerative disease: the story so far
Iqbal, K., Liu, F., & Gong, C.-X. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.225 · Cited by 806
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719
Multi-atlas segmentation of biomedical images: A survey
Iglesias, J. E., & Sabuncu, M. R. (2015) · Medical Image Analysis · doi:10.1016/j.media.2015.06.012 · Cited by 667
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
Sabogal-Guáqueta, A. M., Muñoz‐Manco, J. I., Ramírez‐Pineda, J. R., Lamprea, M. R., Osorio, E., & Cardona‐Gómez, G. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.027 · Cited by 453
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
Busche, M. A., Wegmann, S., Dujardin, S., Commins, C., Schiantarelli, J., Klickstein, N., Kamath, T. V., Carlson, G. A., Nelken, I., & Hyman, B. T. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0289-8 · Cited by 413
Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity
Hanamsagar, R., Alter, M. D., Block, C. S., Sullivan, H., Bolton, J. L., & Bilbo, S. D. (2017) · Glia · doi:10.1002/glia.23176 · Cited by 384
Tau Aggregation and Its Interplay with Amyloid-β
Nisbet, R. M., Polanco, J.-C., Ittner, L. M., & Götz, J. (2015) · Acta Neuropathologica · doi:10.1007/s00401-014-1371-2 · Cited by 359
“AD [47].”
How Can Hearing Loss Cause Dementia?
Griffiths, T. D., Lad, M., Kumar, S., Holmes, E., McMurray, B., Maguire, E. A., Billig, A. J., & Sedley, W. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.003 · Cited by 389
Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit
Aggleton, J. P., Pralus, A., Nelson, A. J. D., & Hornberger, M. (2016) · Brain · doi:10.1093/brain/aww083 · Cited by 378
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
Brickman, A. M., Khan, U., Provenzano, F. A., Yeung, L., SUZUKI, W. A., Schroeter, H., Wall, M. M., Sloan, R. P., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3850 · Cited by 354
Self-citation
Multi-compartment microscopic diffusion imaging
Kaden, E., Kelm, N. D., Carson, R. P., Does, M. D., & Alexander, D. C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.06.002 · Cited by 345
Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions
Baleriola, J., Walker, C. A., Jean, Y. Y., Crary, J. F., Troy, C. M., Nagy, P. L., & Hengst, U. (2014) · Cell · doi:10.1016/j.cell.2014.07.001 · Cited by 352
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology
Schmitz, T. W., Spreng, R. N., Initiative, T. A. D. N., Weiner, M. W., Aisen, P. S. S., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowki, J. Q., Toga, A. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13249 · Cited by 345
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
Wang, M., Roussos, P., McKenzie, A., Zhou, X., Kajiwara, Y., Brennand, K. J., De Luca, G. C., Crary, J. F., Casaccia, P., Buxbaum, J. D., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0355-3 · Cited by 314
Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report
Saltmarche, A. E., Naeser, M. A., Ho, K. F., Hamblin, M. R., & Lim, L. (2017) · Photomedicine and Laser Surgery · doi:10.1089/pho.2016.4227 · Cited by 302
Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity
Hanamsagar, R., Alter, M. D., Block, C. L., Sullivan, H. K., Bolton, J. L., & Bilbo, S. D. (2017) · Glia · doi:10.1002/glia.23277 · Cited by 297
Neuroimaging biomarkers for Alzheimer’s disease.
Márquez, F., & Yassa, M. A. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0325-5 · Cited by 289
Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging
Maaß, A., Lockhart, S. N., Harrison, T. M., Bell, R. K., Mellinger, T. J., Swinnerton, K. N., Baker, S. L., Rabinovici, G. D., & Jagust, W. J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2028-17.2017 · Cited by 298
VDAC1, mitochondrial dysfunction, and Alzheimer’s disease
Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.010 · Cited by 286
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
Fu, H., Rodriguez, G. A., Herman, M., Emrani, S., Nahmani, E., Barrett, G., Figueroa, H. Y., Goldberg, E., Hussaini, S. A., & Duff, K. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.023 · Cited by 264
Self-citation
Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer’s Disease: A Focus on Aducanumab and Lecanemab
Shi, M., Chu, F., Zhu, F., & Zhu, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.870517 · Cited by 275
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs, H. I. L., Hedden, T., Schultz, A. P., Sepulcre, J., Perea, R. D., Amariglio, R. E., Papp, K. V., Rentz, D. M., Sperling, R. A., & Johnson, K. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0070-z · Cited by 270
Functional subregions of the human entorhinal cortex
Maaß, A., Berron, D., Libby, L. A., Ranganath, C., & Düzel, E. (2015) · eLife · doi:10.7554/elife.06426 · Cited by 266
Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms
Li, P., Marshall, L., Oh, G., Jakubowski, J. L., Groot, D., He, Y., Wang, T., Petronis, A., & Labrie, V. (2019) · Nature Communications · doi:10.1038/s41467-019-10101-7 · Cited by 234
Tau-aggregation inhibitor therapy for Alzheimer's disease
Wischik, C. M., Harrington, C. R., & Storey, J. M. D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.008 · Cited by 279
Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer's disease incidence
Brickman, A. M., Zahodne, L. B., Guzman, V. A., Narkhede, A., Meier, I. B., Griffith, E. Y., Provenzano, F. A., Schupf, N., Manly, J. J., Stern, Y., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.019 · Cited by 265
Self-citation
Entorhinal cortex dysfunction in Alzheimer's disease
Igarashi, K. M. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.11.006 · Cited by 276
Tau in neurodegenerative disease
Gao, Y.-L., Wang, N., Sun, F.-R., Cao, X.-P., Zhang, W., & Yu, J.-T. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.04.23 · Cited by 222
Retromer in Alzheimer disease, Parkinson disease and other neurological disorders
Small, S. A., & Petsko, G. A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3896 · Cited by 227
Self-citation
Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation
Howett, D., Castegnaro, A., Krzywicka, K., Hagman, J., Marchment, D., Henson, R. N., Rio, M., King, J. A., Burgess, N., & Chan, D. (2019) · Brain · doi:10.1093/brain/awz116 · Cited by 243
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 242
Exercise and Hippocampal Memory Systems
Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235
Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans
Reagh, Z. M., & Yassa, M. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411250111 · Cited by 239
Neurogenesis in aging and age-related neurodegenerative diseases
Čulig, L., Chu, X., & Bohr, V. A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101636 · Cited by 235
Functional topography of the human entorhinal cortex
Schröder, T. N., Haak, K. V., Jimenez, N. I. Z., Beckmann, C. F., & Doeller, C. F. (2015) · eLife · doi:10.7554/elife.06738 · Cited by 211
Integrating new findings and examining clinical applications of pattern separation
Leal, S. L., & Yassa, M. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0065-1 · Cited by 228
Modifiable Risk Factors for Alzheimer’s Disease
Edwards III, G. A., Gamez, N., Escobedo Jr., G., Calderon, O., & Moreno-Gonzalez, I. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00146 · Cited by 253
Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis
Zhu, M., Wang, X., Hjorth, E., Colas, R. A., Schroeder, L., Granholm, A.-C., Serhan, C. N., & Schultzberg, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9544-0 · Cited by 204
Neurocognitive Aging and the Hippocampus across Species
Leal, S. L., & Yassa, M. A. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.10.003 · Cited by 221
Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits
Reagh, Z. M., Noche, J. A., Tustison, N. J., Delisle, D., Murray, E. A., & Yassa, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.039 · Cited by 212
Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
Sepulcre, J., Grothe, M. J., Uquillas, F. D., Ortiz-Terán, L., Diez, I. P., Yang, H., Jacobs, H. I. L., Hanseeuw, B. J., Li, Q., Fakhri, G. E., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0206-4 · Cited by 195
Left–right dissociation of hippocampal memory processes in mice
Shipton, O. A., El-Gaby, M., Apergis‐Schoute, J., Deisseroth, K. A., Bannerman, D. M., Paulsen, O., & Kohl, M. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405648111 · Cited by 193
Chronic intermittent hypoxia induces oxidative stress and inflammation in brain regions associated with early-stage neurodegeneration
Snyder, B., Shell, B., Cunningham, J. T., & Cunningham, R. L. (2017) · Physiological Reports · doi:10.14814/phy2.13258 · Cited by 190
Amyloid assembly and disassembly
Chuang, E., Hori, A. M., Hesketh, C. D., & Shorter, J. (2018) · Journal of Cell Science · doi:10.1242/jcs.189928 · Cited by 188
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
Nuriel, T., Angulo, S. L., Khan, U., Ashok, A., Chen, Q., Figueroa, H. Y., Emrani, S., Liu, L., Herman, M., Barrett, G., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01444-0 · Cited by 181
Self-citation
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
Rosenberg, J. B., Kaplitt, M. G., De, B. P., Chen, A., Flagiello, T., Salami, C., Pey, E., Zhao, L., Ricart Arbona, R. J., Monette, S., et al. (2018) · Human Gene Therapy Clinical Development · doi:10.1089/humc.2017.231 · Cited by 176
Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease
Jun, H., Bramian, A., Soma, S., Saito, T., Saido, T. C., & Igarashi, K. M. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.023 · Cited by 170
Endosomal traffic jams represent a pathogenic hub and therapeutic target in Alzheimer’s disease
Small, S. A., Simoes-Spassov, S., Mayeux, R., & Petsko, G. A. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.08.003 · Cited by 168
Self-citation
Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17999-3 · Cited by 158
Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
Adams, J. N., Maass, A., Harrison, T. M., Baker, S. L., & Jagust, W. J. (2019) · eLife · doi:10.7554/elife.49132 · Cited by 160
Basal forebrain volume reliably predicts the cortical spread of Alzheimer’s degeneration
Fernández‐Cabello, S., Kronbichler, M., Dijk, K. R. A. V., Goodman, J. A., Spreng, R. N., Schmitz, T. W., & Initiative, O. B. O. T. A. D. N. (2020) · Brain · doi:10.1093/brain/awaa012 · Cited by 159
Age-related functional changes in domain-specific medial temporal lobe pathways
Berron, D., Neumann, K., Maaß, A., Schütze, H., Fließbach, K., Kiven, V., Jessen, F., Sauvage, M. M., Kumaran, D., & Düzel, E. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.12.030 · Cited by 158
Removing inter-subject technical variability in magnetic resonance imaging studies
Fortin, J., Sweeney, E. M., Muschelli, J., Crainiceanu, C. M., & Shinohara, R. T. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.036 · Cited by 158
Linalool Reverses Neuropathological and Behavioral Impairments in Old Triple Transgenic Alzheimer's Mice
Sabogal-Guáqueta, A. M., Osorio, E., & Cardona-Gómez, G. P. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.002 · Cited by 148
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 151
Cerebrospinal fluid β‐amyloid and phospho‐tau biomarker interactions affecting brain structure in preclinical Alzheimer disease
Fortea, J., Vilaplana, E., Alcolea, D. A., Carmona‐Iragui, M., Sánchez‐Saudinós, M., Sala, I., Antón‐Aguirre, S., González‐Ortiz, S., Medrano, S., Pegueroles, J., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24186 · Cited by 140
Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease
Lebois, E. P., Thorn, C. A., Edgerton, J. R., Popiolek, M., & Xi, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.018 · Cited by 145
Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway
Varma, V. R., Varma, S., An, Y., Hohman, T. J., Seddighi, S., Casanova, R., Beri, A., Dammer, E. B., Seyfried, N. T., Pletniková, O., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.206 · Cited by 146
Compromised Grid-Cell-like Representations in Old Age as a Key Mechanism to Explain Age-Related Navigational Deficits
Stangl, M., Achtzehn, J., Huber, K., Dietrich, C., Tempelmann, C., & Wolbers, T. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.038 · Cited by 145
Bacopa monnieri , a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies
Manap, A. S. A., Vijayabalan, S., Madhavan, P., Chia, Y. Y., Arya, A., Wong, E. H., Rizwan, F., Bindal, U., & Koshy, S. (2019) · Drug Target Insights · doi:10.1177/1177392819866412 · Cited by 164
Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease
Initiative, A. D. N., Pascoal, T. A., Mathotaarachchi, S. S., Mohades, S. T., Benedet, A. L., Chung, C.-O., Shin, M., Wang, S., Beaudry, T., Kang, M. S., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.37 · Cited by 137
Multifactorial causal model of brain (dis)organization and therapeutic intervention: Application to Alzheimer’s disease
Iturria‐Medina, Y., Carbonell, F., Sotero, R. C., Chouinard-Decorte, F., & Evans, A. C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.058 · Cited by 130
Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease
Petrache, A. L., Rajulawalla, A., Shi, A., Wetzel, A., Saito, T., Saido, T. C., Harvey, K., & Ali, A. B. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz016 · Cited by 124
A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory
Lopez‐Rojas, J., de Solis, C. A., Leroy, F., Kandel, E. R., & Siegelbaum, S. A. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.028 · Cited by 133
The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease
Ren, Y. L., Savadlou, A., Park, S., Siska, P., Epp, J. R., & Sargin, D. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101061 · Cited by 137
Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study
López, M. E., Bruña, R., Aurtenetxe, S., Pineda‐Pardo, J. A., Marcos, A., Arrazola, J., García, A. I. R., Carrasco, P. M., Bajo, R., & Maestú, F. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0964-14.2014 · Cited by 122
Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease
Kazim, S. F., & Iqbal, K. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0119-y · Cited by 126
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
Hoffman, J. L., Faccidomo, S., Kim, M., Taylor, S. M., Agoglia, A. E., May, A. M., Smith, E. N., Wong, L. C., & Hodge, C. W. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.10.017 · Cited by 113
The Cognitive Control of Eating and Body Weight: It’s More Than What You “Think”
Davidson, T. L., Jones, S., Roy, M., & Stevenson, R. J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00062 · Cited by 125
Tau deposition is associated with functional isolation of the hippocampus in aging
Harrison, T. M., Maaß, A., Adams, J. N., Du, R., Baker, S. L., & Jagust, W. J. (2019) · Nature Communications · doi:10.1038/s41467-019-12921-z · Cited by 113
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
Baloni, P., Arnold, M., Buitrago, L., Nho, K. T., Moreno, H., Huynh, K., Brauner, B., Louie, G., Kueider‐Paisley, A., Suhre, K., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04011-6 · Cited by 117
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
Bennett, H. C., Zhang, Q., Wu, Y.-T., Manjila, S. B., Chon, U., Shin, D., Vanselow, D. J., Pi, H.-J., Drew, P. J., & Kim, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-50559-8 · Cited by 115
Longitudinal brain structural changes in preclinical Alzheimer's disease
Pegueroles, J., Vilaplana, E., Montal, V., Sampedro, F., Alcolea, D. A., Carmona‐Iragui, M., Clarimón, J., Blesa, R., Lleó, A., Fortea, J., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.08.010 · Cited by 106
Human anterolateral entorhinal cortex volumes are associated with cognitive decline in aging prior to clinical diagnosis
Olsen, R. K., Yeung, L., Noly‐Gandon, A., D’Angelo, M. C., Kacollja, A., Smith, V. M., Ryan, J. D., & Barense, M. D. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.04.025 · Cited by 113
Customized Intranasal Hydrogel Delivering Methylene Blue Ameliorates Cognitive Dysfunction against Alzheimer's Disease
Liu, Y., Tan, Y., Cheng, G., Ni, Y., Xie, A., Zhu, X., Yin, C., Zhang, Y., & Chen, T. (2024) · Advanced Materials · doi:10.1002/adma.202307081 · Cited by 116
Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy
Chiarini, A., Armato, U., Gardenal, E., Gui, L., & Prà, I. D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00217 · Cited by 109
Greater loss of object than spatial mnemonic discrimination in aged adults
Reagh, Z. M., Ho, H. D., Leal, S. L., Noche, J. A., Chun, A. P., Murray, E. A., & Yassa, M. A. (2015) · Hippocampus · doi:10.1002/hipo.22562 · Cited by 113
Dynamic relationships between age, amyloid-β deposition, and glucose metabolism link to the regional vulnerability to Alzheimer’s disease
Oh, H., Madison, C. M., Baker, S. L., Rabinovici, G. D., & Jagust, W. J. (2016) · Brain · doi:10.1093/brain/aww108 · Cited by 113
Neuroinflammation in Alzheimer’s Disease: from Pathogenesis to a Therapeutic Target
Pimplikar, S. W. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0032-5 · Cited by 106
Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project
Ritchie, K. A., Ropacki, M. T., Albala, B., Harrison, J., Kaye, J. A., Kramer, J. H., RANDOLPH, C. C., & Ritchie, C. W. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.07.154 · Cited by 111
A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain
Ercan-Herbst, E., Ehrig, J., Schöndorf, D. C., Behrendt, A., Klaus, B., Gomez Ramos, B., Prat Oriol, N., Weber, C., & Ehrnhoefer, D. E. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0823-2 · Cited by 101
Identification of Differentially Expressed Genes through Integrated Study of Alzheimer’s Disease Affected Brain Regions
Puthiyedth, N., Riveros, C., Berretta, R. E., & Moscato, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152342 · Cited by 105
Longitudinal Alzheimer’s Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections
Schmitz, T. W., Mur, M., Aghourian, M., Bédard, M., & Spreng, R. N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.001 · Cited by 99
New perspectives on the basal forebrain cholinergic system in Alzheimer’s disease
Berry, A. S., & Harrison, T. M. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105192 · Cited by 102
Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment
Canuet, L., Pusil, S. A., López, M. E., Bajo, R., Pineda‐Pardo, J. A., Cuesta, P., Gálvez, G., Gaztelu, J. M., Lourido, D., García‐Ribas, G., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0704-15.2015 · Cited by 100
Selective alterations of neurons and circuits related to early memory loss in Alzheimer’s disease
Llorens-Martı́n, M., Blázquez‐Llorca, L., Benavides‐Piccione, R., Rábano, A., Hernández, F., Ávila, J., & DeFelipe, J. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00038 · Cited by 94
Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity
Pereira, J. B., Ossenkoppele, R., Palmqvist, S., Strandberg, T. O., Smith, R. A., Westman, E., & Hansson, O. (2019) · eLife · doi:10.7554/elife.50830 · Cited by 92
A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease
Patir, A., Shih, B., McColl, B. W., & Freeman, T. C. (2019) · Glia · doi:10.1002/glia.23572 · Cited by 90
Rapid and reversible impairment of episodic memory by a high-fat diet in mice
McLean, F. H., Grant, C., Morris, A. C., Horgan, G. W., Polanski, A. J., Allan, K., Campbell, F., Langston, R. F., & Williams, L. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-30265-4 · Cited by 88
Complement C7is a novel risk gene for Alzheimer's disease in Han Chinese
Zhang, D., Fan, Y., Xu, M., Wang, G., Wang, D., Li, J., Kong, L., Zhou, H., Luo, R., Bi, R., et al. (2018) · National Science Review · doi:10.1093/nsr/nwy127 · Cited by 87
Microcircuits for spatial coding in the medial entorhinal cortex
Tukker, J. J., Beed, P. S., Brecht, M., Kempter, R., Moser, E. I., & Schmitz, D. (2021) · Physiological Reviews · doi:10.1152/physrev.00042.2020 · Cited by 95
Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia
Provenzano, F. A., Guo, J., Wall, M. M., Feng, X., Sigmon, H. C., Brucato, G., First, M. B., Rothman, D. L., Girgis, R. R., Lieberman, J. A., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.022 · Cited by 87
Self-citation
Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory
Vandrey, B., Garden, D. L. F., Ambrozova, V., McClure, C., Nolan, M. F., & Ainge, J. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.11.027 · Cited by 86
Impaired Expression of GABA Signaling Components in the Alzheimer’s Disease Middle Temporal Gyrus
Govindpani, K., Turner, C. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228704 · Cited by 86
Critical Appraisal of Amyloid Lowering Agents in AD
Decourt, B., Boumelhem, F., Pope, E. D., Shi, J., Mari, Z. K., & Sabbagh, M. N. (2021) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-021-01125-y · Cited by 87
The hearing hippocampus
Billig, A. J., Lad, M., Sedley, W., & Griffiths, T. D. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102326 · Cited by 92
Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease
Kobro‐Flatmoen, A., Nagelhus, A., & Witter, M. P. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.012 · Cited by 78
Complexity Measures for Quantifying Changes in Electroencephalogram in Alzheimer’s Disease
Al-Nuaimi, A. H. H., Jammeh, E., Sun, L., & Ifeachor, E. (2018) · Complexity · doi:10.1155/2018/8915079 · Cited by 82

Authors: Khan, U. A., Liu, L., Provenzano, F. A., Berman, D. E., Profaci, C. P., Sloan, R., Mayeux, R., Duff, K. E., & Small, S. A.
Affiliations: SUNY Downstate Health Sciences University (US)
Columbia University (US)
Corresponding author: Duff, Karen E
Small, Scott A
ORCID: Khan, Usman A
Liu, Li
Provenzano, Frank A
Berman, Diego E
Profaci, Caterina P
Sloan, Richard
Mayeux, Richard
Duff, Karen E
Small, Scott A
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2013-12-22
Volume: 17
Issue: 2
Pages: 304-311
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3606
PMC: PMC4044925
OpenAlex: W1966100017
Cited by: 561
References: 60
Citations by year: 2026: 23 · 2025: 33 · 2024: 38 · 2023: 52 · 2022: 56 · 2021: 48 · 2020: 51 · 2019: 54 · 2018: 59 · 2017: 54 · 2016: 36 · 2015: 31 · 2014: 23 · 2013: 1
FWCI: 21.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Ministerio de Economía y Competitividad
National Institute on Aging (R01AG034618, R01AG037212, P01AG007232, AG 07232, AG025161, R01AG025161, P50AG008702, AG037212, AG034618)
National Heart, Lung, and Blood Institute (R01HL094423, HL094423)
National Institute of Neurological Disorders and Stroke (NS074874, R01NS074874)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007430)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: preclinical Alzheimer's disease, lateral entorhinal cortex, medial entorhinal cortex, amyloid precursor protein, tau protein, parietal cortex, regional vulnerability, mouse models of Alzheimer's disease
MeSH terms: Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Animals, Brain Mapping, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Oxygen, Cortical Spreading Depression, Gene Expression, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Disease Progression, Entorhinal Cortex, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks