Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
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Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer’s disease (AD) is hypothesized to involve amyloid-β (Aβ) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC and posteromedial EC (pmEC), subregions of EC that differ in functional specialization and cortical connectivity, with the hypothesis that alEC-connected cortex would show greater tau deposition than pmEC-connected cortex. We used resting state fMRI to measure FC, and PET to measure tau and Aβ in cognitively normal older adults. Tau preferentially deposited in alEC-connected cortex compared to pmEC-connected or non-connected cortex, and stronger connectivity was associated with increased tau deposition. FC-tau relationships were present regardless of Aβ, although strengthened with Aβ. These results provide an explanation for the anatomic specificity of neocortical tau deposition in the aging brain and reveal relationships between normal aging and the evolution of AD.
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The vulnerability of entorhinal neurons has been reported in previous studies.
“The vulnerability of the entorhinal neurons has been reported in many previous studies (Adams et al., 2019, Rodriguez et al., 2019, Braak and Del Tredici, 2020).”
From Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis (2020) · cites this paper as Adams et al., 2019
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- Authors
- Adams, J. N., Maass, A., Harrison, T. M., Baker, S. L., & Jagust, W. J.
- Affiliations
- University of California, Berkeley (US)
- German Center for Neurodegenerative Diseases (DE)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Adams, Jenna N
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2019-09-02
- Volume
- 8
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC6764824
- OpenAlex
- W2971637931
- Cited by
- 160
- References
- 70
- Citations by year
- 2026: 10 · 2025: 29 · 2024: 30 · 2023: 20 · 2022: 27 · 2021: 34 · 2020: 8 · 2019: 1
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R01-AG034570, F32-AG057107)
- Helmholtz-Gemeinschaft (Postdoc Program PD-306)
- Tau Consortium
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- tau deposition, entorhinal cortex, functional connectivity, brain aging, Alzheimer's disease, amyloid-beta, transentorhinal cortex, resting-state fMRI, positron emission tomography, cognitive aging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Amyloid beta-Peptides, tau Proteins, Entorhinal Cortex, Positron-Emission Tomography, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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