The DOI matches its Crossref record; 105 of the 106 references it cites were found in a registry or an index.
Normal and abnormal coding of somatosensory stimuli causing pain
Open accessAbstract
Noxious stimuli usually cause pain and pain usually arises from noxious stimuli, but exceptions to these apparent truisms are the basis for clinically important problems and provide valuable insight into the neural code for pain. In this Review, we discuss how painful sensations arise. We argue that, although primary somatosensory afferents are tuned to specific stimulus features, natural stimuli often activate more than one type of afferent. Manipulating coactivation patterns can alter perception in ways that argue against each type of afferent acting independently (as expected for strictly labeled lines), suggesting instead that signals conveyed by different types of afferents interact. Deciphering the central circuits that mediate those interactions is critical for explaining the generation and modulation of neural signals that ultimately elicit pain. The advent of genetic and optical dissection techniques promise to dramatically accelerate progress toward this goal, which will facilitate the rational design of future pain therapeutics.
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“Many studies have delved into the relationship between optogenetic stimulation and neurological disorders and control, such as Parkinson's,[557] Alzheimer's,[558] spinal cord injuries,[559] and somatosensory nociception,[560,561] which have indistinguishable relationship with prosthetic control, feedback, and human movement rehabilitation.”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [558]
In the citing paper
“Nerve injury induces hyperexcitability, thereby causing functional alterations in the neuronal network such as loss of function of inhibitory neurons in the dorsal horn, and results in neuropathic pain (Prescott et al, 2014;Todd, 2010).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Prescott et al, 2014
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1 of the 106 references couldn’t be matched to a known paper.
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Rôles et régulations des canaux ioniques ASIC1b dans la douleur
Verkest, C. (2019) · theses.fr (ABES) · doi:10.70675/db17aabazd726z4d22zb273zf58b049ba711
Vagal neuropathies: An underrecognized potential driver of physical, mental, and immune symptoms
Chen, B., & Gautron, L. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101252
Huft, K., Gaydos, E. F., White, J. N., Pascual‐Diaz, S., Schubert-Hjalmarsson, E., Harrison, N., Moua, L., Hoeppli, M., Biggs, E. E., Stinson, J., et al. (2026) · Pain · doi:10.1097/j.pain.0000000000003999
Primary and Secondary Chronic Musculoskeletal Pain Syndromes
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Self-citationDual-frequency spinal cord stimulation increases responder rates for treatment of neuropathic pain
Lambert, K. M., Zhang, T. C., Gilbert, J. E., Moffitt, M. A., & Grill, W. M. (2026) · Pain · doi:10.1097/j.pain.0000000000004036
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An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli
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Metadata
- Authors
- Prescott, S. A., Ma, Q., & De Koninck, Y.
- Affiliations
- University of Toronto (CA)
- Harvard University (US)
- Corresponding author
- Prescott, Steven A
- Venue
- Nature Neuroscience
- Published
- 2014-01-28
- Volume
- 17
- Issue
- 2
- Pages
- 183-191
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4079041
- OpenAlex
- W2028575493
- Cited by
- 210
- References
- 106
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 18 · 2020: 10 · 2019: 10 · 2018: 31 · 2017: 14 · 2016: 24 · 2015: 21 · 2014: 7
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Canadian Institutes of Health Research (MOP12942)
- National Institute of Neurological Disorders and Stroke (P01NS072040, R01NS086372, R01NS047710, R21NS074146, R01NS076706, P01 NS0272040)
- National Institute of Dental and Craniofacial Research (R01DE018025)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain, somatosensory afferents, neural coding, noxious stimuli, labeled lines, pain perception, pain modulation, pain therapeutics
- MeSH terms
- Afferent Pathways, Animals, Humans, Models, Biological, Nociceptors, Pain, Perception, Physical Stimulation
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