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Normal and abnormal coding of somatosensory stimuli causing pain

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Prescott, Steven A, Ma, Qiufu, De Koninck, Yves·2014·Nature Neuroscience

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Abstract

Noxious stimuli usually cause pain and pain usually arises from noxious stimuli, but exceptions to these apparent truisms are the basis for clinically important problems and provide valuable insight into the neural code for pain. In this Review, we discuss how painful sensations arise. We argue that, although primary somatosensory afferents are tuned to specific stimulus features, natural stimuli often activate more than one type of afferent. Manipulating coactivation patterns can alter perception in ways that argue against each type of afferent acting independently (as expected for strictly labeled lines), suggesting instead that signals conveyed by different types of afferents interact. Deciphering the central circuits that mediate those interactions is critical for explaining the generation and modulation of neural signals that ultimately elicit pain. The advent of genetic and optical dissection techniques promise to dramatically accelerate progress toward this goal, which will facilitate the rational design of future pain therapeutics.

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A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486
A theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578
The Bayesian brain: The role of uncertainty in neural coding and computation
Knill, D. C., & Pouget, A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.007 · Cited by 2,588
Combinatorial Receptor Codes for Odors
Malnic, B., Hirono, J., Sato, T., & Buck, L. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80581-4 · Cited by 2,302
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
Costigan, M., Scholz, J., & Woolf, C. J. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135531 · Cited by 2,025
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
The Petilla Interneuron Nomenclature Group (PING) (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2402 · Cited by 1,491
Whole-brain functional imaging at cellular resolution using light-sheet microscopy
Ahrens, M. B., Orger, M. B., Robson, D. N., Li, J. M., & Keller, P. J. (2013) · Nature Methods · doi:10.1038/nmeth.2434 · Cited by 1,392
Topographic organization of sensory projections to the olfactory bulb
Vassar, R. J., Chao, S. K., Sitcheran, R., ̃ez, J. M. N., Vosshall, L. B., & Axel, R. (1994) · Cell · doi:10.1016/0092-8674(94)90029-9 · Cited by 1,281
An Expanded Palette of Genetically Encoded Ca 2+ Indicators
Zhao, Y., Araki, S., Wu, J., Teramoto, T., Chang, Y.-F., Nakano, M., Abdelfattah, A. S., Fujiwara, M., Ishihara, T., Nagai, T., et al. (2011) · Science · doi:10.1126/science.1208592 · Cited by 1,265
Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons
Wickersham, I. R., Lyon, D. C., Barnard, R. J. O., Mori, T., Finke, S., Conzelmann, K., Young, J. A. T., & Callaway, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.033 · Cited by 1,176
Miniaturized integration of a fluorescence microscope
Ghosh, K. K., Burns, L. D., Cocker, E. D., Nimmerjahn, A., Ziv, Y., Gamal, A. E., & Schnitzer, M. J. (2011) · Nature Methods · doi:10.1038/nmeth.1694 · Cited by 1,130
Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes
Maier, C., Baron, R., Tölle, T. R., Binder, A., Birbaumer, N., Birklein, F., Gierthmühlen, J., Flor, H., Geber, C., Huge, V., et al. (2010) · Pain · doi:10.1016/j.pain.2010.05.002 · Cited by 1,021
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
Buch, T., Heppner, F. L., Tertilt, C., Heinen, T. J. A. J., Kremer, M., Wunderlich, F. T., Jung, S., & Waisman, A. (2005) · Nature Methods · doi:10.1038/nmeth762 · Cited by 922
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors
Kobayashi, K., Fukuoka, T., Obata, K., Yamanaka, H., Dai, Y., Tokunaga, A., & Noguchi, K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20794 · Cited by 766
Optogenetic investigation of neural circuits underlying brain disease in animal models
Tye, K. M., & Deisseroth, K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3171 · Cited by 745
Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor
Mantyh, P. W., Rogers, S. D., Honoré, P., Allen, B. J., Ghilardi, J. R., Li, J., Daughters, R. S., Lappi, D. A., Wiley, R. G., & Simone, D. A. (1997) · Science · doi:10.1126/science.278.5336.275 · Cited by 634
Probabilistic brains: knowns and unknowns
Pouget, A., Beck, J. M., Ma, W. J., & Latham, P. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3495 · Cited by 615
Cellular Basis of Itch Sensation
Sun, Y.-G., Zhao, Z.-Q., Meng, X.-L., Yin, J., Liu, X., & Chen, Z. (2009) · Science · doi:10.1126/science.1174868 · Cited by 612
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with Aδ/C-fibers and colocalization with Trk receptors
小林, 希. (2007) · Medical Entomology and Zoology · Cited by 575
Central mechanisms of odour object perception
Gottfried, J. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2883 · Cited by 549
Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice
Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Noda, M., Inui, Y., Mekada, E., Kimata, Y., Tsuru, A., & Kohno, K. (2001) · Nature Biotechnology · doi:10.1038/90795 · Cited by 512
The Cells and Circuitry for Itch Responses in Mice
Mishra, S. K., & Hoon, M. A. (2013) · Science · doi:10.1126/science.1233765 · Cited by 507
The Thermal Grill Illusion: Unmasking the Burn of Cold Pain
Craig, A. D., & Bushnell, M. C. (1994) · Science · doi:10.1126/science.8023144 · Cited by 497
The machinery of colour vision
Solomon, S. G., & Lennie, P. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2094 · Cited by 455
Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
Ross, S. E., Mardinly, A. R., McCord, A. E., Zurawski, J. D., Cohen, S., Jung, C. C., Hu, L. S., Mok, S. I., Shah, A., Savner, E. M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.025 · Cited by 445
Self-citation
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
Andersson, L. S., Larhammar, M., Memic, F., Wootz, H., Schwochow, D., Rubin, C., Patra, K., Árnason, T., Wellbring, L., Hjälm, G., et al. (2012) · Nature · doi:10.1038/nature11399 · Cited by 431
Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord
Torsney, C., & MacDermott, A. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4584-05.2006 · Cited by 407
Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
Gross, M. K., Dottori, M., & Goulding, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00690-6 · Cited by 396
The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
Müller, T., Brohmann, H., Pierani, A., Heppenstall, P. A., Lewin, G. R., Jessell, T. M., & Birchmeier, C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00689-x · Cited by 368
Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition
Ray, R. S., Corcoran, A. E., Brust, R. D., Kim, J. C., Richerson, G. B., Nattie, E., & Dymecki, S. M. (2011) · Science · doi:10.1126/science.1205295 · Cited by 363
Targeting neurons and photons for optogenetics
Packer, A. M., Roska, B., & Häusser, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3427 · Cited by 359
Nanotools for Neuroscience and Brain Activity Mapping
Alivisatos, A. P., Andrews, A. M., Boyden, E. S., Chun, M., Church, G. M., Deisseroth, K. A., Donoghue, J. P., Fraser, S. E., Lippincott‐Schwartz, J., Looger, L. L., et al. (2013) · ACS Nano · doi:10.1021/nn4012847 · Cited by 359
Specification of dorsal spinal cord interneurons
Helms, A. W., & Johnson, J. E. B. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00010-2 · Cited by 357
Chloride extrusion enhancers as novel therapeutics for neurological diseases
Gagnon, M., Bergeron, M. J., Lavertu, G., Castonguay, A., Tripathy, S., Bonin, R. P., Pérez-Sánchez, J., Boudreau, D., Wang, B., Dumas, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3356 · Cited by 357
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P. A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1221 · Cited by 350
Self-citation
Microglia Control Neuronal Network Excitability via BDNF Signalling
Ferrini, F., & Koninck, Y. D. (2013) · Neural Plasticity · doi:10.1155/2013/429815 · Cited by 334
The localization of classical transmitters and neuropeptides within neurons in laminae I–III of the mammalian spinal dorsal horn
Todd, A. J., & SPIKE, R. C. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90045-t · Cited by 330
Proprioceptor Pathway Development Is Dependent on MATH1
Bermingham, N. A., Hassan, B. A., Wang, V. Y., Fernandez, M., Banfi, S., Bellen, H. J., Fritzsch, B., & Zoghbi, H. Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00305-1 · Cited by 304
A critique of pure vision
Churchland, P. S., Ramachandran, V. S., & B, T. J. S. A. (1993) · PhilPapers (PhilPapers Foundation) · Cited by 302
A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia
Lü, Y., Dong, H., Gao, Y., Gong, Y., Ren, Y., Gu, N., Zhou, S., Xia, N., Sun, Y., Ji, R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70026 · Cited by 287
A Specific Inhibitory Pathway between Substantia Gelatinosa Neurons Receiving Direct C-Fiber Input
Lü, Y., & Perl, E. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08752.2003 · Cited by 286
Transformation of the Output of Spinal Lamina I Neurons After Nerve Injury and Microglia Stimulation Underlying Neuropathic Pain
Keller, A. F., Beggs, S., Salter, M. W., & Koninck, Y. D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-27 · Cited by 278
Fibre function and perception during cutaneous nerve block.
Mackenzie, R. A., Burke, D. J., Skuse, N. F., & Lethlean, A. K. (1975) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.38.9.865 · Cited by 274
Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn
Baba, H., Ji, R., Kohno, T., Moore, K. A., Ataka, T., Wakai, A., Okamoto, M., & Woolf, C. J. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00236-7 · Cited by 274
Placebo analgesia: Psychological and neurobiological mechanisms
Colloca, L., Klinger, R., Flor, H., & Bingel, U. (2013) · Pain · doi:10.1016/j.pain.2013.02.002 · Cited by 263
Modular Organization of Excitatory Circuits between Neurons of the Spinal Superficial Dorsal Horn (Laminae I and II)
Lü, Y., & Perl, E. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0102-05.2005 · Cited by 255
Optogenetic pharmacology for control of native neuronal signaling proteins
Krämer, R., Mourot, A., & Adesnik, H. (2013) · Nature Neuroscience · doi:10.1038/nn.3424 · Cited by 253
Ideas about pain, a historical view
Perl, E. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2042 · Cited by 249
Neurotoxic marine poisoning
Isbister, G. K., & Kiernan, M. C. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70041-7 · Cited by 241
Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons
Miraucourt, L. S., Dallel, R., & Voisin, D. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001116 · Cited by 227
Acute pain in an emergency clinic: Latency of onset and descriptor patterns related to different injuries
Melzack, R., Wall, P., & Ty, T. C. (1982) · Pain · doi:10.1016/0304-3959(82)90078-1 · Cited by 226
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn
Glasgow, S. M., Henke, R. M., MacDonald, R. J., Wright, C. V. E., & Johnson, J. E. (2005) · Development · doi:10.1242/dev.02167 · Cited by 225
Physiological Properties of the Lamina I Spinoparabrachial Neurons in the Rat
Bester, H., Chapman, V., Besson, J., & Bernard, J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.2239 · Cited by 223
RELEASE OF COLD-INDUCED BURNING PAIN BY BLOCK OF COLD-SPECIFIC AFFERENT INPUT
Yarnitsky, D., & Ochoa, J. L. (1990) · Brain · doi:10.1093/brain/113.4.893 · Cited by 220
Color Vision, Cones, and Color-Coding in the Cortex
Conway, B. R. (2009) · The Neuroscientist · doi:10.1177/1073858408331369 · Cited by 210
Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
Cheng, L., Samad, O. A., Xu, Y., Mizuguchi, R., Luo, P., Shirasawa, S., Goulding, M., & Ma, Q. (2005) · Nature Neuroscience · doi:10.1038/nn1569 · Cited by 198
Self-citation
Labeled lines meet and talk: population coding of somatic sensations
Ma, Q. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43426 · Cited by 176
Self-citation
Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice
Daou, I., Tuttle, A. H., Longo, G., Wieskopf, J. S., Bonin, R. P., Ase, A. R., Wood, J. N., De Koninck, Y., Ribeiro-da-Silva, A., Mogil, J. S., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2424-13.2013 · Cited by 175
Sensory determinants of thermal pain
Defrin, R., Ohry, A., Blumen, N., & Urca, G. (2002) · Brain · doi:10.1093/brain/awf055 · Cited by 169
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage
Sikand, P., Shimada, S. G., Green, B. G., & LaMotte, R. H. (2009) · Pain · doi:10.1016/j.pain.2009.03.001 · Cited by 160
A microprobe for parallel optical and electrical recordings from single neurons in vivo
LeChasseur, Y., Dufour, S., Lavertu, G., Bories, C., Deschênes, M., Vallée, R., & Koninck, Y. D. (2011) · Nature Methods · doi:10.1038/nmeth.1572 · Cited by 157
Human cutaneous C fibres activated by cooling, heating and menthol
Campero, M., Baumann, T., Bostock, H., & Ochoa, J. L. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.176040 · Cited by 154
Morphological, neurochemical and electrophysiological features of parvalbumin‐expressing cells: a likely source of axo‐axonic inputs in the mouse spinal dorsal horn
Hughes, D. I., Sikander, S., Kinnon, C. M., Boyle, K. A., Watanabe, M., Callister, R. J., & Graham, B. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235655 · Cited by 151
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
Müller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M., & Birchmeier, C. (2005) · Genes & Development · doi:10.1101/gad.326105 · Cited by 150
Linking Genetically Defined Neurons to Behavior through a Broadly Applicable Silencing Allele
Kim, J. C., Cook, M. N., Carey, M. R., Shen, C., Regehr, W. G., & Dymecki, S. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.010 · Cited by 138
Circuits for Grasping: Spinal dI3 Interneurons Mediate Cutaneous Control of Motor Behavior
Bui, T. V., Akay, T., Loubani, O. M., Hnasko, T. S., Jessell, T. M., & Brownstone, R. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.007 · Cited by 135
Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats
Carstens, E. E., Carstens, M. I., Simons, C. T., & Jinks, S. L. (2010) · Neuroreport · doi:10.1097/wnr.0b013e328337310a · Cited by 135
The Paired Homeodomain Protein DRG11 Is Required for the Projection of Cutaneous Sensory Afferent Fibers to the Dorsal Spinal Cord
Chen, Z., Rebelo, S., White, F. A., Malmberg, A. B., Baba, H., Lima, D., Woolf, C. J., Basbaum, A. I., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00341-5 · Cited by 134
Luxotonic responses of units in macaque striate cortex
Kayama, Y., Riso, R. R., Bartlett, J. R., & Doty, R. W. (1979) · Journal of Neurophysiology · doi:10.1152/jn.1979.42.6.1495 · Cited by 131
Excitatory Superficial Dorsal Horn Interneurons Are Functionally Heterogeneous and Required for the Full Behavioral Expression of Pain and Itch
Wang, X., Zhang, J., Eberhart, D. E., Urban, R., Meda, K., Solórzano, C., Yamanaka, H., Rice, D. S., & Basbaum, A. I. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.001 · Cited by 129
The triple cold syndrome
Ochoa, J. L., & Yarnitsky, D. (1994) · Brain · doi:10.1093/brain/117.1.185 · Cited by 127
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
Vetter, I., Touška, F., Hess, A., Hinsbey, R., Sattler, S., Lampert, A., Sergejeva, M., Sharov, A., Collins, L. S., Eberhardt, M. J., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.207 · Cited by 116
Molecular Neuroanatomy's “Three Gs”: A Primer
Dymecki, S. M., & Kim, J. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.009 · Cited by 110
Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents
Zheng, J., Lü, Y., & Perl, E. R. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.188052 · Cited by 102
CONGENITAL UNIVERSAL INSENSITIVITY TO PAIN
BAXTER, D. W., & Olszewski, J. (1960) · Brain · doi:10.1093/brain/83.3.381 · Cited by 100
Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons.
Huang, M.-G., Huang, T., Xiang, Y., Xie, Z., Chen, Y., Yan, R., Xu, J., & Cheng, L.-P. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.06.031 · Cited by 99
Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn
Polgár, E., Sardella, T. C. P., Tiong, S. Y. X., Locke, S., Watanabe, M., & Todd, A. J. (2013) · Pain · doi:10.1016/j.pain.2013.05.001 · Cited by 96
Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons
Takazawa, T., & Macdermott, A. (2010) · Journal of Physiology · doi:10.1113/jphysiol.2010.188292 · Cited by 94
A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord
Bröhl, D., Strehle, M., Wende, H., Hori, K., Bormuth, I., Nave, K., Müller, T. H., & Birchmeier, C. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.002 · Cited by 90
Free-Energy and Illusions: The Cornsweet Effect
Brown, H. R., & Friston, K. J. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00043 · Cited by 88
Population coding of somatic sensations
Ma, Q. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1201-2 · Cited by 79
Self-citation
Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons
Xu, Y., Lopes, C., Qian, Y., Liu, Y., Cheng, L., Goulding, M., Turner, E. E., Lima, D., & Ma, Q. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4126-07.2008 · Cited by 76
Self-citation
Adaptive Movement Compensation for In Vivo Imaging of Fast Cellular Dynamics within a Moving Tissue
Laffray, S., Pagès, S., Dufour, H., Koninck, P. D., Koninck, Y. D., & Côté, D. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019928 · Cited by 73
Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord
Mesnage, B., Gaillard, S., Godin, A. G., Rodeau, J., Hammer, M., Von Engelhardt, J., Wiseman, P. W., De Koninck, Y., Schlichter, R., & Cordero‐Erausquin, M. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22668 · Cited by 71
Enhancing K–Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model
Lavertu, G., Côté, S., & Koninck, Y. D. (2013) · Brain · doi:10.1093/brain/awt334 · Cited by 71
Representation of pain in the brain
Bushnell, M. C., & Apkarian, A. V. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50011-4 · Cited by 70
Functional imaging in freely moving animals
Kerr, J. N. D., & Nimmerjahn, A. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.002 · Cited by 67
Innocuous cooling can produce nociceptive sensations that are inhibited during dynamic mechanical contact
Green, B. G., & Pope, J. V. (2003) · Experimental Brain Research · doi:10.1007/s00221-002-1280-9 · Cited by 66
Ontogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities
Xu, Y., Lopes, C., Wende, H., Guo, Z., Cheng, L., Birchmeier, C., & Ma, Q. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5512-12.2013 · Cited by 63
Self-citation
A STUDY OF POST-ISCHAeMIC PARAeSTHESIAe
Merrington, W. R., & Nathan, P. W. (1949) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.12.1.1 · Cited by 59
Pain processing by spinal microcircuits: afferent combinatorics
Prescott, S. A., & Ratté, S. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.02.010 · Cited by 57
Self-citation
Inhibitory Coupling between Inhibitory Interneurons in the Spinal Cord Dorsal Horn
Labrakakis, C., Lorenzo, L.-É., Bories, C., Ribeiro‐da‐Silva, A., & Koninck, Y. D. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-24 · Cited by 56
Dorsal horn neurons presynaptic to lamina I spinoparabrachial neurons revealed by transynaptic labeling
Cordero‐Erausquin, M., Allard, S., Dolique, T., Bachand, K., Ribeiro‐da‐Silva, A., & Koninck, Y. D. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22179 · Cited by 53
Paradoxical heat sensations during moderate cooling of the skin
̈inen, H. H. ̈. ̈., Vartiainen, M. A., Karvanen, L., & Järvilehto, T. (1982) · Brain Research · doi:10.1016/0006-8993(82)91275-6 · Cited by 52
Morphological and Neurochemical Organization of the Spinal Dorsal Horn
Ribeiro‐da‐Silva, A., & Koninck, Y. D. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00163-8 · Cited by 48
Live animal myelin histomorphometry of the spinal cord with video-rate multimodal nonlinear microendoscopy
Bélanger, E., Crépeau, J., Laffray, S., Vallée, R., Koninck, Y. D., & Côté, D. C. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.2.021107 · Cited by 45
Tlx1/3 and Ptf1a Control the Expression of Distinct Sets of Transmitter and Peptide Receptor Genes in the Developing Dorsal Spinal Cord
Guo, Z., Zhao, C., Huang, M., Huang, T., Fan, M., Xie, Z., Chen, Y., Zhao, X., Xia, G., Geng, J., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6301-11.2012 · Cited by 39
Can the basis for central neuropathic pain be identified by using a thermal grill?
Craig, A. D. (2008) · Pain · doi:10.1016/j.pain.2008.01.022 · Cited by 30
ISCHAEMIC AND POST-ISCHAEMIC NUMBNESS AND PARAESTHESIAE
Nathan, P. W. (1958) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.21.1.12 · Cited by 29
Odorant receptor diversity and patterned gene expression in the mammalian olfactory epithelium.
Sullivan, S. L., Ressler, K. J., & Buck, L. B. (1994) · PubMed · Cited by 28
Laminar optical tomography of the hemodynamic response in the lumbar spinal cord of rats
Ouakli, N., Guevara, E., Dubeau, S., Beaumont, É., & Lesage, F. (2010) · Optics Express · doi:10.1364/oe.18.010068 · Cited by 25
Evidence that tactile stimulation inhibits nociceptive sensations produced by innocuous contact cooling
Green, B. G., & Schoen, K. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.015 · Cited by 21
In vivo single-cell excitability probing of neuronal ensembles in the intact and awake developing Xenopus brain
Dunfield, D., & Haas, K. Z. (2010) · Nature Protocols · doi:10.1038/nprot.2010.10 · Cited by 11

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1 of the 106 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Kumazawa, T., Mizunura, K. & Kruger, L. eds. The Polymodal Receptor: A Gateway to Pain (Elsevier, 1996).
Craig, A.D. Mechanisms of thalamic pain. in Central Neuropathic Pain: Focus on Poststroke Pain (ed. Henry, J.L., Panju, A. & Yashpal, K.) 81–100 (IASP Press, Seattle, 2007).

Sorted by citations

Transition from acute to chronic pain after surgery
Glare, P., Aubrey, K. R., & Myles, P. S. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30352-6 · Cited by 914
Structural plasticity and reorganisation in chronic pain
Kuner, R., & Flor, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.162 · Cited by 700
Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics
Heng, W., Solomon, S., & Gao, W. (2022) · Advanced Materials · doi:10.1002/adma.202107902 · Cited by 609
Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.003 · Cited by 582
Self-citation
Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types
Häring, M., Zeisel, A., Hochgerner, H., Rinwa, P., Jakobsson, J. E. T., Lönnerberg, P., La Manno, G., Sharma, N., Borgius, L., Kiehn, O., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0141-1 · Cited by 470

See all 210

Authors: Prescott, S. A., Ma, Q., & De Koninck, Y.
Affiliations: University of Toronto (CA)
Harvard University (US)
Corresponding author: Prescott, Steven A
ORCID: Prescott, Steven A
Ma, Qiufu
De Koninck, Yves
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-01-28
Volume: 17
Issue: 2
Pages: 183-191
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3629
PMC: PMC4079041
OpenAlex: W2028575493
Cited by: 210
References: 106
Citations by year: 2026: 14 · 2025: 13 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 18 · 2020: 10 · 2019: 10 · 2018: 31 · 2017: 14 · 2016: 24 · 2015: 21 · 2014: 7
FWCI: 2.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Canadian Institutes of Health Research (MOP12942)
National Institute of Neurological Disorders and Stroke (P01NS072040, R01NS086372, R01NS047710, R21NS074146, R01NS076706, P01 NS0272040)
National Institute of Dental and Craniofacial Research (R01DE018025)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: pain, somatosensory afferents, neural coding, noxious stimuli, labeled lines, pain perception, pain modulation, pain therapeutics
MeSH terms: Afferent Pathways, Animals, Humans, Models, Biological, Nociceptors, Pain, Perception, Physical Stimulation

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Normal and abnormal coding of somatosensory stimuli causing pain

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