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Normal and abnormal coding of somatosensory stimuli causing pain

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Prescott, Steven A, Ma, Qiufu, De Koninck, Yves·2014·Nature Neuroscience

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Abstract

Noxious stimuli usually cause pain and pain usually arises from noxious stimuli, but exceptions to these apparent truisms are the basis for clinically important problems and provide valuable insight into the neural code for pain. In this Review, we discuss how painful sensations arise. We argue that, although primary somatosensory afferents are tuned to specific stimulus features, natural stimuli often activate more than one type of afferent. Manipulating coactivation patterns can alter perception in ways that argue against each type of afferent acting independently (as expected for strictly labeled lines), suggesting instead that signals conveyed by different types of afferents interact. Deciphering the central circuits that mediate those interactions is critical for explaining the generation and modulation of neural signals that ultimately elicit pain. The advent of genetic and optical dissection techniques promise to dramatically accelerate progress toward this goal, which will facilitate the rational design of future pain therapeutics.

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Authors: Prescott, S. A., Ma, Q., & De Koninck, Y.
Affiliations: University of Toronto (CA)
Harvard University (US)
Corresponding author: Prescott, Steven A
ORCID: Prescott, Steven A
Ma, Qiufu
De Koninck, Yves
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-01-28
Volume: 17
Issue: 2
Pages: 183-191
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3629
PMC: PMC4079041
OpenAlex: W2028575493
Cited by: 210
References: 106
Citations by year: 2026: 14 · 2025: 13 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 18 · 2020: 10 · 2019: 10 · 2018: 31 · 2017: 14 · 2016: 24 · 2015: 21 · 2014: 7
FWCI: 2.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Canadian Institutes of Health Research (MOP12942)
National Institute of Neurological Disorders and Stroke (P01NS072040, R01NS086372, R01NS047710, R21NS074146, R01NS076706, P01 NS0272040)
National Institute of Dental and Craniofacial Research (R01DE018025)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: pain, somatosensory afferents, neural coding, noxious stimuli, labeled lines, pain perception, pain modulation, pain therapeutics
MeSH terms: Afferent Pathways, Animals, Humans, Models, Biological, Nociceptors, Pain, Perception, Physical Stimulation

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Normal and abnormal coding of somatosensory stimuli causing pain

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