Single App knock-in mouse models of Alzheimer’s disease

Saito, Takashi, Matsuba, Yukio, Mihira, Naomi, Takano, Jiro, Nilsson, Per, Itohara, Shigeyoshi, Iwata, Nobuhisa, Saido, Takaomi C·2014·Nature Neuroscience

DOI 10.1038/nn.3697

Cited by (1,333)

Items 101–200 of 1,333

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H., Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K. et al. · 2022 · Molecular Neurodegeneration
Homeostatic Microglia Initially Seed and Activated Microglia Later Reshape Amyloid Plaques in Alzheimer's Disease
Baligács, Nóra, Albertini, Giulia, Borrie, Sarah C., Serneels, Lutgarde, Pridans, Clare, Balusu, Sriram, De Strooper, Bart · 2024 · Nature Communications
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression
Saito, Takashi, Matsuba, Yukio, Yamazaki, Naomi, Hashimoto, Shoko, Saido, Takaomi C. · 2016 · The Journal of Neuroscience
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
Javier Rueda‐Carrasco, Dimitra Sokolova, Sang‐Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z. Ge, Joanne Lachica, Christina E. Toomey et al. · 2023 · The EMBO Journal
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology
Tanaka, Hikari, Homma, Hidenori, Fujita, Kyota, Kondo, Kanoh, Yamada, Shingo, Jin, Xiaocen, Waragai, Masaaki, Ohtomo, Gaku, Iwata, Atsushi, Tagawa, Kazuhiko et al. · 2020 · Nature Communications
Neuroinflammation in mouse models of Alzheimer's disease
Takashi Saito, Takaomi C. Saido · 2018 · Clinical and Experimental Neuroimmunology
Leveraging preclinical models for the development of Alzheimer disease therapeutics
Kimberly A. Scearce-Levie, Pascal E. Sanchez, Joseph W. Lewcock · 2020 · Nature Reviews Drug Discovery
Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics
Sala Frigerio, Carlo, De Strooper, Bart · 2016 · Annual Review of Neuroscience
Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells
Shirotani, Keiro, Hori, Yuma, Yoshizaki, Ryohei, Higuchi, Eri, Colonna, Marco, Saito, Takashi, Hashimoto, Shoko, Saito, Takashi, Saido, Takaomi C., Iwata, Nobuhisa · 2019 · Scientific Reports
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice
Sasmita, Andrew Octavian, Depp, Constanze, Nazarenko, Taisiia, Sun, Ting, Siems, Sophie B., Ong, Erinne Cherisse, Nkeh, Yakum B., Böhler, Carolin, Yu, Xuan, Bues, Bastian et al. · 2024 · Nature Neuroscience
Adult hippocampal neurogenesis and its impairment in Alzheimer’s disease
Thomas Aquinas Kim, Michelle D Syty, Kaitlyn Wu, Shaoyu Ge · 2022 · 动物学研究
Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease
Harpreet Kaur, Kumi Nagamoto‐Combs, Svetlana A. Golovko, Mikhail Y. Golovko, Marilyn G. Klug, Colin Kelly Combs · 2020 · Neurobiology of Aging
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology
David Baglietto‐Vargas, Stefânia Forner, Lena Cai, Alessandra Cadete Martini, Laura Trujillo‐Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine M. Tran et al. · 2021 · Nature Communications
The KEAP1-NRF2 System and Neurodegenerative Diseases
Akira Uruno, Masayuki P. Yamamoto · 2023 · Antioxidants and Redox Signaling
Tau binding protein CAPON induces tau aggregation and neurodegeneration
Hashimoto, Shoko, Matsuba, Yukio, Kamano, Naoko, Mihira, Naomi, Sahara, Naruhiko, Takano, Jiro, Muramatsu, Shin-ichi, Saido, Takaomi C., Saito, Takashi · 2019 · Nature Communications
Humanising the mouse genome piece by piece
Fei Zhu, R. Nair, Elizabeth Fisher, Thomas J. Cunningham · 2019 · Nature Communications
Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease
Dalila Mango, Amira Saidi, Giusy Ylenia Cisale, Marco Feligioni, Massimo Corbo, Robert Nisticò · 2019 · Frontiers in Pharmacology
Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease
Natalia Mast, Aicha Saadane, Ana Carolina Valencia‐Olvera, James Constans, Erin Maxfield, Hiroyuki Arakawa, Young Li, Gary E. Landreth, Irina A. Pikuleva · 2017 · Neuropharmacology
Exploring the efficacy of natural products in alleviating Alzheimer’s disease
Amit Singh, Prajakta Deshpande, Neha Gogia · 2019 · Neural Regeneration Research
New Mouse Model of Alzheimer’s
Nilsson, Per, Saito, Takashi, Saido, Takaomi C · 2014 · ACS Chemical Neuroscience
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
Kaji, Seiji, Berghoff, Stefan A., Spieth, Lena, Schlaphoff, Lennart, Sasmita, Andrew O., Vitale, Simona, Büschgens, Luca, Kedia, Shreeya, Zirngibl, Martin, Nazarenko, Taisiia et al. · 2024 · Immunity
Tau physiology and pathomechanisms in frontotemporal lobar degeneration
Bodea, Liviu‐Gabriel, Eckert, Anne, Ittner, Lars Matthias, Piguet, Olivier, Götz, Jürgen · 2016 · Journal of Neurochemistry
The cellular model for Alzheimer's disease research: PC12 cells
Danni Xie, Ting Deng, Zhenwei Zhai, Tao Sun, Ying Dong Xu · 2023 · Frontiers in Molecular Neuroscience
Transgenic Mice Overexpressing Amyloid Precursor Protein Exhibit Early Metabolic Deficits and a Pathologically Low Leptin State Associated with Hypothalamic Dysfunction in Arcuate Neuropeptide Y Neurons
Makoto Ishii, G. Wang, Gianfranco Racchumi, Jonathan P. Dyke, Costantino Iadecola · 2014 · Journal of Neuroscience
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
Joshua M. Spurrier, LaShae Nicholson, Xiaotian T. Fang, Austin J. Stoner, Takuya Toyonaga, Daniel Holden, Timothy R. Siegert, Will Laird, Mary Alice Allnutt, Marius Chiasseu et al. · 2022 · Science Translational Medicine
Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide
Jizhi Ni, Atsuhiko Taniguchi, Shuta Ozawa, Yukiko Hori, Yoichiro Kuninobu, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Youhei Sohma, Motomu Kanai · 2018 · Chem
Unsupervised excitation: GABAergic dysfunctions in Alzheimer’s disease
Eleonora Ambrad Giovannetti, Martin Fuhrmann · 2018 · Brain Research
An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody
Mykhailo Y. Batiuk, Filip de Vin, Sandra I. Duqué, Chen Li, Takashi Saito, Takaomi C. Saido, Mark W. E. J. Fiers, T. Grant Belgard, Matthew G. Holt · 2017 · Journal of Biological Chemistry
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Feng Pan · 2023 · Molecular Neurodegeneration
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Francesc Xavier Guix, Ragna Sannerud, Fedor Berditchevski, Amaia M. Arranz, Katrien Horré, An Snellinx, Amantha Thathiah, Takaomi C. Saido, Takashi Saito, Sundaresan Rajesh et al. · 2017 · Molecular Neurodegeneration
Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
Carpanini, Sarah M., Torvell, Megan, Bevan, Ryan J., Byrne, Robert A. J., Daskoulidou, Nikoleta, Saito, Takashi, Saido, Takaomi C., Taylor, Philip R., Hughes, Timothy R., Zelek, Wioleta M. et al. · 2022 · Acta Neuropathologica Communications
Treadmill Exercise Prevents Decline in Spatial Learning and Memory in 3×Tg-AD Mice through Enhancement of Structural Synaptic Plasticity of the Hippocampus and Prefrontal Cortex
Lianwei Mu, Jiajia Cai, Boya Gu, Laikang Yu, Cui Li, Qing-song Liu, Li Zhao · 2022 · Cells
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew‐Yeu Peak‐Chew, Takashi Saito, Takaomi C. Saido, Jennifer A. Macdonald et al. · 2023 · Acta Neuropathologica
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice
Park, Hanseul, Cho, Byounggook, Kim, Hongwon, Saito, Takashi, Saido, Takaomi C., Won, Kyoung-Jae, Kim, Jongpil · 2023 · Nature Communications
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition
Latif-Hernandez, Amira, Shah, Disha, Craessaerts, Kathleen, Saido, Takaomi, Saito, Takashi, De Strooper, Bart, Van der Linden, Annemie, D’Hooge, Rudi · 2019 · Behavioural Brain Research
Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Takashi, Saido, Takaomi C., Iijima, Koichi M. · 2018 · BMC Neuroscience
Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
Nils Korte, Anna Barkaway, Jack A. Wells, Felipe Freitas, Huma Sethi, Stephen P. Andrews, John Skidmore, Beth Stevens, David Attwell · 2024 · Nature Neuroscience
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models
Yunhong Huang, Aneta Skwarek‐Maruszewska, Katrien Horré, Elke Vandewyer, Leen Wolfs, An Snellinx, Takashi Saito, Enrico Radaelli, Nikky Corthout, Julien Colombelli et al. · 2015 · Science Translational Medicine
The domestic cat as a natural animal model of Alzheimer’s disease
James Kenn CHAMBERS, Takahiko Tokuda, Kazuyuki Uchida, Ryotaro Ishii, Harutsugu Tatebe, Erika Takahashi, Takami Tomiyama, Yumi Une, Hiroyuki Nakayama · 2015 · Acta Neuropathologica Communications
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions
Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, Takashi Saito, Takaomi C. Saido, Naoyuki Taniguchi · 2015 · Biochemical Journal
Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer’s disease
Whyte, Lauren S., Hemsley, Kim M., Lau, Adeline A., Hassiotis, Sofia, Saito, Takashi, Saido, Takaomi C., Hopwood, John J., Sargeant, Timothy J. · 2018 · Behavioural Brain Research
Epidemiology of Dementia: The Burden on Society, the Challenges for Research
Frank J. Wolters, M. Arfan Ikram · 2018 · Methods in molecular biology
Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches
Julia Rosauro Clarke, Felipe Campos Ribeiro, Rudimar Luiz Frozza, Fernanda G. De Felice, Mychael V. Lourenco · 2018 · Journal of Alzheimer s Disease
Istradefylline reduces memory deficits in aging mice with amyloid pathology
Orr, Anna G., Lo, Iris, Schumacher, Heike, Ho, Kaitlyn, Gill, Michael, Guo, Weikun, Kim, Daniel H., Knox, Anthony, Saito, Takashi, Saido, Takaomi C. et al. · 2018 · Neurobiology of Disease
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease
Hanseul Park, Jaein Shin, Yun-Kyung Kim, Takashi Saito, Takaomi C. Saido, Jongpil Kim · 2022 · Translational Neurodegeneration
Bridging the gap: large animal models in neurodegenerative research
Samantha L. Eaton, Thomas M. Wishart · 2017 · Mammalian Genome
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
Li, Hongmei, Guo, Qinxi, Inoue, Taeko, Polito, Vinicia A, Tabuchi, Katsuhiko, Hammer, Robert E, Pautler, Robia G, Taffet, George E, Zheng, Hui · 2014 · Molecular Neurodegeneration
High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow.
Bracko, Oliver, Vinarcsik, Lindsay K., Cruz Hernández, Jean C., Ruiz-Uribe, Nancy E., Haft-Javaherian, Mohammad, Falkenhain, Kaja, Ramanauskaite, Egle M., Ali, Muhammad, Mohapatra, Aditi, Swallow, Madisen A. et al. · 2020 · Scientific Reports
Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology
Cai, Wenwen, Li, Linxi, Sang, Shaoming, Pan, Xiaoli, Zhong, Chunjiu · 2023 · Neuroscience Bulletin
β-Amyloid Prions and the Pathobiology of Alzheimer’s Disease
Joel C. Watts, Stanley B. Prusiner · 2017 · Cold Spring Harbor Perspectives in Medicine
AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer's Disease
Abraham Fisher, Безпрозванный Илья Борисович, Lili Wu, Daniel A. Ryskamp, Nira Bar-Ner, Niva Natan, Rachel Brandeis, Hanoch Elkon, Victoria Nahum, Eytan Gershonov et al. · 2015 · Neurodegenerative Diseases
Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models
Naia, Luana, Shimozawa, Makoto, Bereczki, Erika, Li, Xidan, Liu, Jianping, Jiang, Richeng, Giraud, Romain, Leal, Nuno Santos, Pinho, Catarina Moreira, Berger, Erik et al. · 2023 · Molecular Psychiatry
Mouse models of neurodegeneration: Know your question, know your mouse
Elizabeth Fisher, David M. Bannerman · 2019 · Science Translational Medicine
Blood and cerebrospinal fluid neurofilament light differentially detect neurodegeneration in early Alzheimer’s disease
Emelie Andersson, Shorena Janelidze, Björn Lampinen, Markus Nilsson, Antoine Leuzy, Erik Stomrud, Kaj Blennow, Henrik Zetterberg, Oskar Hansson · 2020 · Neurobiology of Aging
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia
Diana P. Benítez, Shenyi Jiang, Jack I. Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Sean Man Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith et al. · 2021 · Molecular Neurodegeneration
Low-cost solution for rodent home-cage behaviour monitoring
Surjeet Singh, Edgar J. Bermudez-Contreras, Mojtaba Nazari, Robert J. Sutherland, Majid H. Mohajerani · 2019 · PLoS ONE
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains
Sharoar, Md Golam, Palko, Sarah, Ge, Yingying, Saido, Takaomi C., Yan, Riqiang · 2021 · Molecular Neurodegeneration
Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease
Lutgarde Serneels, Dries T’Syen, Laura Pérez‐Benito, Tom Theys, Matthew G. Holt, Bart De Strooper · 2020 · Molecular Neurodegeneration
Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
Yvonne S. Eisele, Charles J. Duyckaerts · 2015 · Acta Neuropathologica
BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis
Zhe Wang, Qin Xu, Fang Cai, Xi Liu, Yili Wu, Weihong Song · 2019 · JCI Insight
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain
Tomonori Aikawa, Yingxue Ren, Yu Yamazaki, Masaya Tachibana, Madeleine R. Johnson, Casey T. Anderson, Yuka A. Martens, Marie‐Louise Holm, Yan W. Asmann, Takashi Saito et al. · 2019 · Proceedings of the National Academy of Sciences
Effects of Probiotic Supplementation on Short Chain Fatty Acids in the App NL - G - F Mouse Model of Alzheimer’s Disease
Harpreet Kaur, Svetlana A. Golovko, Mikhail Y. Golovko, Surjeet Singh, Diane C. Darland, Colin Kelly Combs · 2020 · Journal of Alzheimer s Disease
Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor
Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Xiaoyun Zhou, Maiko Ono, Yukio Matsuba, Bin Ji, Hideki Ishii, Masanao Ogawa, Hiroyasu Akatsu et al. · 2021 · Brain Communications
Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus
Gustavo A. Rodriguez, Geoffrey Barrett, Karen Duff, S. Abid Hussaini · 2020 · PLoS Biology
A Review of the Current Mammalian Models of Alzheimer’s Disease and Challenges That Need to Be Overcome
Natasha E. Mckean, Renée R. Handley, Russell G. Snell · 2021 · International Journal of Molecular Sciences
Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm
Shoko Hashimoto, Ayano Ishii, Naoko Kamano, Naoto Watamura, Takashi Saito, Toshio Ohshima, Makoto Yokosuka, Takaomi C. Saido · 2018 · Journal of Biological Chemistry
Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models
Wirths, Oliver, Zampar, Silvia · 2020 · International Journal of Molecular Sciences
Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice
Kundu, Payel, Torres, Eileen Ruth S., Stagaman, Keaton, Kasschau, Kristin, Okhovat, Mariam, Holden, Sarah, Ward, Samantha, Nevonen, Kimberly A., Davis, Brett A., Saito, Takashi et al. · 2021 · Scientific Reports
Rodent Models of Amyloid-Beta Feature of Alzheimer’s Disease: Development and Potential Treatment Implications
Chi Him Poon, Yingyi Wang, Man‐Lung Fung, Chengfei Zhang, Lee Wei Lim · 2020 · Aging and Disease
Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models
Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Luana Naia, Antonio Piras, Caroline Graff, Antonino Cattaneo, Giovanni Meli, Maho Hamasaki, Per Nilsson et al. · 2020 · Cells
Catalytic photooxygenation degrades brain Aβ in vivo
Nozomu Nagashima, Shuta Ozawa, Masahiro Furuta, Miku Oi, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai · 2021 · Science Advances
The Brain–Gut Axis, an Important Player in Alzheimer and Parkinson Disease: A Narrative Review
Eugenio Caradonna, Raffaello Nemni, Angelo Bifone, Patrizia Gandolfo, Lucy Costantino, Luca Giordano, Elisabetta Mormone, Anna Macula, Mariarosa Cuomo, Rossana Difruscolo et al. · 2024 · Journal of Clinical Medicine
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer’s disease
Luis Enrique Arroyo‐García, Arturo G. Isla, Yuniesky Andrade‐Talavera, Hugo Balleza‐Tapia, Raúl Loera‐Valencia, Laura Alvarez-Jimenez, Giusy Pizzirusso, Simone Tambaro, Per Nilsson, André Fisahn · 2021 · Molecular Psychiatry
Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1
Johnson, Erik C. B., Ho, Kaitlyn, Yu, Gui-Qiu, Das, Melanie, Sanchez, Pascal E., Djukic, Biljana, Lopez, Isabel, Yu, Xinxing, Gill, Michael, Zhang, Weiping et al. · 2020 · Molecular Neurodegeneration
Probiotic Bifidobacterium breve Prevents Memory Impairment Through the Reduction of Both Amyloid-β Production and Microglia Activation in APP Knock-In Mouse
Mona Abdelhamid, Chunyu Zhou, Kazuya Ohno, Tetsuya Kuhara, Ferdous Taslima, Mohammad Abdullah, Cha-Gyun Jung, Makoto Michikawa · 2021 · Journal of Alzheimer s Disease
Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model
Tomoaki Nakazono, Travis N. Lam, Ayushi Y. Patel, Masashi Kitazawa, Takashi Saito, Takaomi C. Saido, Kei M. Igarashi · 2017 · Frontiers in Systems Neuroscience
Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How
Lewandowski, Cutler T., Maldonado Weng, Juan, LaDu, Mary Jo · 2020 · Neurobiology of Disease
A comprehensive guide to studying inflammasome activation and cell death
Rebecca E. Tweedell, R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti · 2020 · Nature Protocols
Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research
Granzotto, Alberto, Vissel, Bryce, Sensi, Stefano L · 2024 · eLife
The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons
Dmitry A. Ovchinnikov, Othmar Korn, Isaac Virshup, Christine Anne Wells, Ernst Jurgen Wolvetang · 2018 · Stem Cell Reports
Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease
Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey Ines Kautzmann, William C. Gordon, Per Nilsson, Nicolas Guillermo Bazan, Marianne Schultzberg · 2021 · Acta Neuropathologica Communications
TSPO imaging in animal models of brain diseases
Nadja Van Camp, Sonia Lavisse, Pauline Roost, Francesco Gubinelli, Ansel T. Hillmer, Hervé Boutin · 2021 · European Journal of Nuclear Medicine and Molecular Imaging
Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology
Manasee Gedam, Michele M. Comerota, Nicholas E. Propson, Tao Chen, Feng Jin, Meng Carla Wang, Hui Zheng · 2023 · Journal of Clinical Investigation
Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the <scp>APPswePS1dE9</scp> mouse model
Smit, Tamar, Deshayes, Natasja A. C., Borchelt, David R., Kamphuis, Willem, Middeldorp, Jinte, Hol, Elly M. · 2021 · Glia
Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly
Michael Harvey Hastings, Marco Brancaccio, Maria F. Gonzalez-Aponte, Erik D. Herzog · 2023 · Annual Review of Neuroscience
The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease
Yuan Liang, Congcong Liu, Manman Cheng, Lijie Geng, Jing Li, Wenying Du, Minfang Song, Nian Chen, Traore Aicha Noura Yeleen, Song Li et al. · 2024 · Alzheimer s & Dementia
An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases
Alexandra I. Mot, Constanze Depp, Klaus‐Armin Nave · 2018 · Dialogues in Clinical Neuroscience
Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease
Steffen E. Storck, Claus U. Pietrzik · 2017 · Pharmaceutical Research
Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease
Junhua Xie, Nina Gorlé, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Caroline Van Cauwenberghe, Eef Parthoens, Evelien Van Hamme, Saskia Lippens, Lien Van Hoecke et al. · 2021 · Acta Neuropathologica Communications
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease
Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa Marinha, Rafaela Morais‐Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría et al. · 2023 · Nature Neuroscience
Cerebral Hypoperfusion and Other Shared Brain Pathologies in Ischemic Stroke and Alzheimer’s Disease
Shuying Dong, Shelly Maniar, Mioara D. Manole, Dandan Sun · 2017 · Translational Stroke Research
Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
Hiroki Sasaguri, Kenichi Nagata, Misaki Sekiguchi, Ryo Fujioka, Yukio Matsuba, Shoko Hashimoto, Kaori Sato, Deepika Kurup, Takanori Yokota, Takaomi C. Saido · 2018 · Nature Communications
Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor
Daniel Ryskamp Rijsketic, Lili Wu, Jun Wu, Da Bin Kim, Gerhard Rammes, Michal Geva, Michael R. Hayden, Безпрозванный Илья Борисович · 2018 · Neurobiology of Disease
Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use
Cristina d’Abramo, Luciano D'adamio, Luca Giliberto · 2020 · Journal of Personalized Medicine
Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 mice
Andrea Locci, Hector Orellana, Guadalupe Rodríguez, Meredith Gottliebson, Bryan M. McClarty, Sky Dominguez, Rachel M. Keszycki, Hongxin Dong · 2021 · Behavioural Brain Research
Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer’s Disease-Related Pathologies in Wild-Type Mice
Mona Abdelhamid, Chunyu Zhou, Cha‐Gyun Jung, Makoto Michikawa · 2022 · Nutrients
Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model
Wu, Xiaoting, Miller, James Alastair, Lee, Bernett Teck Kwong, Wang, Yulan, Ruedl, Christiane · 2025 · Science Advances
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily S. Meymand, Modupe F. Olufemi, Pyry P. Koivula, Shaniya Maimaiti et al. · 2021 · Acta Neuropathologica Communications
Fecal microbiota transplantation can improve cognition in patients with cognitive decline and Clostridioides difficile infection
Soo-Hyun Park, Jung Hwan Lee, Jun‐Seob Kim, Tae Jung Kim, Jongbeom Shin, Jae Hyoung Im, Boram Cha, Suhjoon Lee, Kye Sook Kwon, Yong Woon Shin et al. · 2022 · Aging
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
Naoto Watamura, Martha S. Foiani, Sumi Bez, Mathieu Bourdenx, Alessia Santambrogio, Claire Frodsham, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Saisha Patel et al. · 2024 · Nature Neuroscience