Cited by 158Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors

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Dietrich, Marcelo O, Bober, Jeremy, Ferreira, Jozélia G, Tellez, Luis A, Mineur, Yann S, Souza, Diogo O, Gao, Xiao-Bing, Picciotto, Marina R +3 more·2012·Nature Neuroscience

Abstract

It is not known whether behaviors unrelated to feeding are affected by hypothalamic regulators of hunger. We found that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1 knockdown in AgRP-expressing neurons or early postnatal ablation of these neurons increased exploratory behavior and enhanced responses to cocaine. In AgRP circuit-impaired mice, ventral tegmental dopamine neurons exhibited enhanced spike timing-dependent long-term potentiation, altered amplitude of miniature postsynaptic currents and elevated dopamine in basal forebrain. Thus, AgRP neurons determine the set point of the reward circuitry and associated behaviors.

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Authors
Dietrich, M. O., Bober, J., Ferreira, J. G., Tellez, L. A., Mineur, Y. S., Souza, D. O., Gao, X.-B., Picciotto, M. R., Araújo, I., Liu, Z.-W., & Horvath, T. L.
Affiliations
  • Yale University (US)
  • Universidade Federal do Rio Grande do Sul (BR)
Venue
Nature Neuroscience
Published
2012-06-24
Volume
15
Issue
8
Pages
1108-1110
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2093684418
Cited by
158
References
14
Citations by year
2026: 2 · 2025: 10 · 2024: 9 · 2023: 5 · 2022: 17 · 2021: 13 · 2020: 12 · 2019: 14 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 18 · 2014: 12 · 2013: 13 · 2012: 5
FWCI
6.80
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Washington
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Financiadora de Estudos e Projetos
  • National Institutes of Health
  • National Institute on Deafness and Other Communication Disorders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058, R01DK080000)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
AgRP neurons, hypothalamus, SIRT1, dopaminergic neurons, ventral tegmental area, exploratory behavior, miniature postsynaptic currents, reward systems, feeding behavior
MeSH terms
Animals, Behavior, Animal, Cocaine, Dopamine, Female, Mice, Transgenic, Neuronal Plasticity, Neurons, Reward, Long-Term Potentiation, Mice, Agouti-Related Protein, Gene Knockdown Techniques, Dopaminergic Neurons

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