AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
Open accessAbstract
It is not known whether behaviors unrelated to feeding are affected by hypothalamic regulators of hunger. We found that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1 knockdown in AgRP-expressing neurons or early postnatal ablation of these neurons increased exploratory behavior and enhanced responses to cocaine. In AgRP circuit-impaired mice, ventral tegmental dopamine neurons exhibited enhanced spike timing-dependent long-term potentiation, altered amplitude of miniature postsynaptic currents and elevated dopamine in basal forebrain. Thus, AgRP neurons determine the set point of the reward circuitry and associated behaviors.
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AgRP neurons in the ARC play a role in setting VTA dopamine neuronal activity and determining reward-associated behaviors.
“AgRP neurons in the ARC have been shown to innervate the VTA and play a role in setting VTA dopamine neuronal activity and determining reward-associated behaviors [89].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [89]
AgRP neurons in the ARC innervate the VTA.
“AgRP neurons in the ARC have been shown to innervate the VTA and play a role in setting VTA dopamine neuronal activity and determining reward-associated behaviors [89].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [89]
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- Authors
- Dietrich, M. O., Bober, J., Ferreira, J. G., Tellez, L. A., Mineur, Y. S., Souza, D. O., Gao, X.-B., Picciotto, M. R., Araújo, I., Liu, Z.-W., & Horvath, T. L.
- Affiliations
- Yale University (US)
- Universidade Federal do Rio Grande do Sul (BR)
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2012-06-24
- Volume
- 15
- Issue
- 8
- Pages
- 1108-1110
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3411867
- OpenAlex
- W2093684418
- Cited by
- 158
- References
- 14
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 9 · 2023: 5 · 2022: 17 · 2021: 13 · 2020: 12 · 2019: 14 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 18 · 2014: 12 · 2013: 13 · 2012: 5
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Washington
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Financiadora de Estudos e Projetos
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058, R01DK080000)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- AgRP neurons, hypothalamus, SIRT1, dopaminergic neurons, ventral tegmental area, exploratory behavior, miniature postsynaptic currents, reward systems, feeding behavior
- MeSH terms
- Animals, Behavior, Animal, Cocaine, Dopamine, Female, Mice, Transgenic, Neuronal Plasticity, Neurons, Reward, Long-Term Potentiation, Mice, Agouti-Related Protein, Gene Knockdown Techniques, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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