Tactile frequency discrimination is enhanced by circumventing neocortical adaptation
Abstract
Neocortical responses typically adapt to repeated sensory stimulation, improving sensitivity to stimulus changes, but possibly also imposing limitations on perception. For example, it is unclear whether information about stimulus frequency is perturbed by adaptation or encoded by precise response timing. We addressed this question in rat barrel cortex by comparing performance in behavioral tasks with either whisker stimulation, which causes frequency-dependent adaptation, or optical activation of cortically expressed channelrhodopsin-2, which elicits non-adapting neural responses. Circumventing adaption by optical activation substantially improved cross-hemispheric discrimination of stimulus frequency. This improvement persisted when temporal precision of optically evoked spikes was reduced. We were able to replicate whisker-driven behavior only by applying adaptation rules mimicking sensory-evoked responses to optical stimuli. Conversely, in a change-detection task, animals performed better with whisker than optical stimulation. Our results directly demonstrate that sensory adaptation critically governs the perception of stimulus patterns, decreasing fidelity under steady-state conditions in favor of change detection.
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The peaks of epochs 2 and 2' are likely associated with coding of a mismatch signal notifying downstream circuits of the appearance of a sudden deviance in sensory flow.
“Therefore, the peaks of epochs 2 and 2’ are likely associated with coding of mismatch signal (41) notifying the downstream circuits of the appearance of a sudden deviance (42) in sensory flow.”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [42]
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- Authors
- Musall, S., von der Behrens, W., Mayrhofer, J. M., Weber, B., Helmchen, F., & Haiss, F.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Musall, Simon
- Venue
- Nature Neuroscience
- Published
- 2014-09-21
- Volume
- 17
- Issue
- 11
- Pages
- 1567-1573
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2001351860
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 11 · 2018: 2 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 2
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- sensory adaptation, whisker stimulation, barrel cortex, optogenetics, channelrhodopsin-2, change detection, spike timing
- MeSH terms
- Action Potentials, Adaptation, Physiological, Animals, Behavior, Animal, Female, Somatosensory Cortex, Touch, Vibrissae, Rats, Sprague-Dawley, Neocortex, Pattern Recognition, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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