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A positive-negative mode of population covariation links brain connectivity, demographics and behavior
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We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.
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“Along those lines, a 'positive-negative' axis of brain-behavior covariation describes a similar connectivity spectrum, distinguishing the DMN from sensory/motor regions [63].”
From Situating the default-mode network along a principal gradient of macroscale cortical organization (2016) · cites this paper as [63]
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“Precedent exists for using PCA to extract network-level patterns from high-dimensional neural data, including fMRI (Smith et al., 2015), EEG (Blankertz et al., 2011), and even LLM embeddings (Ethayarajh, 2019).”
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Metadata
- Authors
- Smith, S. M., Nichols, T. E., Vidaurre, D., Winkler, A. M., Behrens, T. E. J., Glasser, M. F., Ugurbil, K., Barch, D. M., Van Essen, D. C., & Miller, K. L.
- Affiliations
- University of Oxford (GB)
- University of Warwick (GB)
- Washington University in St. Louis (US)
- Corresponding author
- Smith, Stephen M
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2015-09-28
- Volume
- 18
- Issue
- 11
- Pages
- 1565-1567
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4625579
- OpenAlex
- W1828334443
- Cited by
- 859
- References
- 27
- Citations by year
- 2026: 44 · 2025: 70 · 2024: 73 · 2023: 58 · 2022: 73 · 2021: 100 · 2020: 162 · 2019: 82 · 2018: 81 · 2017: 70 · 2016: 41 · 2015: 5
- FWCI
- 39.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley) (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (104765/Z/14/Z, 098369/Z/12/Z, 098369, 104765, 100309/A/12/Z, 091509/Z/10/Z, 100309)
- National Institutes of Health (5u54mh091657-05)
- Engineering and Physical Sciences Research Council (EP/J005444/1)
- National Institute of Mental Health (1U54 MH091657, U54-MH091657, F30MH097312)
- National Institute of Neurological Disorders and Stroke (P30NS057091)
- National Institute of Biomedical Imaging and Bioengineering (EB015894, P41EB015894)
- National Center for Research Resources (P41RR008079, P41RR08079)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- brain functional connectivity, lifestyle, psychometric measures, behavioral measures, Human Connectome Project
- MeSH terms
- Adult, Behavior, Brain, Demography, Female, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Nerve Net, Cluster Analysis, Young Adult, Connectome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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