Cited by 1,090Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and Applications

The Human Connectome Project's neuroimaging approach

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Glasser, Matthew F, Smith, Stephen M, Marcus, Daniel S, Andersson, Jesper L R, Auerbach, Edward J, Behrens, Timothy E J, Coalson, Timothy S, Harms, Michael P +8 more·2016·Nature Neuroscience

Abstract

Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The 'HCP-style' paradigm has seven core tenets: (i) collect multimodal imaging data from many subjects; (ii) acquire data at high spatial and temporal resolution; (iii) preprocess data to minimize distortions, blurring and temporal artifacts; (iv) represent data using the natural geometry of cortical and subcortical structures; (v) accurately align corresponding brain areas across subjects and studies; (vi) analyze data using neurobiologically accurate brain parcellations; and (vii) share published data via user-friendly databases. We illustrate the HCP-style paradigm using existing HCP data sets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease.

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  • DWI is currently the only tool to map short and long-range structural brain connectivity in vivo and is essential for comparing brains, detecting differences, and simulating brain activity.

    “Despite any limitations, DWI is currently the only tool to map short and long-range structural brain connectivity in vivo and is essential for comparing brains, detecting differences, and simulating brain activity39.”

    From Tractography-based connectomes are dominated by false-positive connections (2016) · cites this paper as [39]

    The section on comprehensive non-invasive brain mapping says diffusion MRI and tractography can estimate structural brain connectivity in vivo, and that HCP data can be used to investigate individual variability. It does not say DWI is the only tool for mapping both short- and long-range connections, or that it is essential for comparing brains, detecting differences, or simulating brain activity. No page number is provided in our copy. (LLM, conf=0.88)

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Authors
Glasser, M. F., Smith, S. M., Marcus, D. S., Andersson, J. L. R., Auerbach, E. J., Behrens, T. E. J., Coalson, T. S., Harms, M. P., Jenkinson, M., Moeller, S., Robinson, E. C., Sotiropoulos, S. N., Xu, J., Yacoub, E., Ugurbil, K., & Van Essen, D. C.
Affiliations
  • Washington University in St. Louis (US)
  • John Radcliffe Hospital (GB)
  • University of Minnesota (US)
  • Imperial College London (GB)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Glasser, Matthew F
Venue
Nature Neuroscience
Published
2016-08-26
Volume
19
Issue
9
Pages
1175-1187
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2507387536
Cited by
1,090
References
119
Citations by year
2026: 96 · 2025: 127 · 2024: 125 · 2023: 114 · 2022: 138 · 2021: 146 · 2020: 95 · 2019: 114 · 2018: 70 · 2017: 53 · 2016: 12
FWCI
8.69
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Repository@Nottingham (University of Nottingham) (acceptedVersion, other-oa)
  • Nottingham ePrints (University of Nottingham) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Funders
  • Wellcome Trust (104765/Z/14/Z, 098369/Z/12/Z)
  • National Institutes of Health (5u54mh091657-05)
  • Engineering and Physical Sciences Research Council (EP/L023067/1)
  • National Institute of Mental Health (R01MH060974, U54-MH091657, R24MH108315, F30MH097312)
  • National Institute of Neurological Disorders and Stroke (P30NS048056)
  • National Institute of Biomedical Imaging and Bioengineering (P41EB015894, R01EB009352)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
Human Connectome Project, multimodal neuroimaging, data preprocessing, brain parcellation, neuroimaging data sharing, neuroimaging database, high spatial and temporal resolution, temporal artifacts
MeSH terms
Brain, Humans, Magnetic Resonance Imaging, Neuroimaging, Connectome

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