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Cited by 437Functional Brain Connectivity StudiesMental Health Research TopicsNeural and Behavioral Psychology Studies

Linked dimensions of psychopathology and connectivity in functional brain networks

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Xia, Cedric Huchuan, Ma, Zongming, Ciric, Rastko, Gu, Shi, Betzel, Richard F., Kaczkurkin, Antonia N., Calkins, Monica E., Cook, Philip A. +13 more·2018·Nature Communications
DOI 10.1038/s41467-018-05317-yPMC PMC6070480

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Abstract

Neurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity suggests dimensional circuit-level abnormalities that cross diagnoses. Here we seek to identify brain-based dimensions of psychopathology using sparse canonical correlation analysis in a sample of 663 youths. This analysis reveals correlated patterns of functional connectivity and psychiatric symptoms. We find that four dimensions of psychopathology – mood, psychosis, fear, and externalizing behavior – are associated ( r = 0.68–0.71) with distinct patterns of connectivity. Loss of network segregation between the default mode network and executive networks emerges as a common feature across all dimensions. Connectivity linked to mood and psychosis becomes more prominent with development, and sex differences are present for connectivity related to mood and fear. Critically, findings largely replicate in an independent dataset ( n = 336). These results delineate connectivity-guided dimensions of psychopathology that cross clinical diagnostic categories, which could serve as a foundation for developing network-based biomarkers in psychiatry.

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  • Multiple psychiatric disorders are associated with alterations in functional connectivity of frontoparietal and cingulo-opercular networks at rest.

    “In particular, multiple psychiatric disorders are associated with hypoactivation of the FPN and CON during CC tasks [2, 204], alterations in functional connectivity of these networks at rest [3, 205], and alterations in gray matter volume in nodes of these networks, including the dorsal ACC, insula, and dorsomedial and vmPFC [2, 3, 206].”

    From The role of prefrontal cortex in cognitive control and executive function (2022) · cites this paper as [205]

    The Results (‘Common and dissociable patterns of connectivity’; page unavailable) link several psychopathology dimensions to altered resting-state connectivity involving the fronto-parietal network. But the paper lists the cingulo-opercular and salience networks separately (Fig. 2), and the cited findings identify the salience network, not specifically the cingulo-opercular network. Its findings also concern symptom dimensions that cross diagnoses rather than comparisons across multiple diagnosed disorders. (LLM, conf=0.83)

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Cited by

Sorted by citations

Authors
Xia, C. H., Ma, Z., Ciric, R., Gu, S., Betzel, R. F., Kaczkurkin, A. N., Calkins, M. E., Cook, P. A., García de la Garza, A., Vandekar, S. N., Cui, Z., Moore, T. M., Roalf, D. R., Ruparel, K., Wolf, D. H., Davatzikos, C., Gur, R. C., Gur, R. E., Shinohara, R. T., Bassett, D. S., & Satterthwaite, T. D.
Affiliations
  • University of Pennsylvania (US)
  • University of Electronic Science and Technology of China (CN)
Corresponding author
Satterthwaite, Theodore D.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2018-08-01
Volume
9
Issue
1
Pages
3003-3003
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-018-05317-y
PMC
PMC6070480
OpenAlex
W2766963537
Cited by
437
References
31
Citations by year
2026: 46 · 2025: 51 · 2024: 63 · 2023: 46 · 2022: 57 · 2021: 69 · 2020: 58 · 2019: 36 · 2018: 11
FWCI
25.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • IUScholarWorks Open (Indiana University) (submittedVersion)
Funders
  • U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH107703, R01MH112847, R21MH106799, R01MH107235, MH089983, MH089924, P50MH096891, R01MH101111, K01MH102609, K08MH079364)
  • U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (R01EB022573)
  • U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS085211)
  • Dowshen Program for Neuroscience
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
functional brain networks, functional connectivity, psychiatric symptoms, mood, psychosis, fear, externalizing problems, default mode network, frontoparietal network, network segregation, developmental changes, sex differences, adolescents, network-based biomarkers, sparse canonical correlation analysis
MeSH terms
Adolescent, Adult, Brain, Child, Female, Humans, Male, Nerve Net, Psychopathology, Sex Characteristics, Reproducibility of Results, Cohort Studies, Multivariate Analysis, Young Adult

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