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Bidirectional prefrontal-hippocampal interactions support context-guided memory
Open accessAbstract
We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.
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“Theta oscillations in the hippocampus precede those in the PFC during the onset of contextual exploration, while the prefrontal cortical theta precedes that in the hippocampus during the onset of object exploration”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Place et al., 2016
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Prefrontal–hippocampal interactions in episodic memory
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“, 2014, 2017), we hypothesized that experimental head injury could disrupt neurophysiological function in two critical brain regions subserving these functions, namely, the hippocampus and medial prefrontal cortex (McDonald et al., 2002; Sigurdsson and Duvarci, 2015; Place et al., 2016).”
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“…context, hippocampal networks send information about the context to the prefrontal cortex, whereas when the animal subsequently evaluates the object choices, prefrontal networks send information to the hippocampus, presumably to guide retrieval of the appropriate memories (Place et al. 2016).”
Background
Metadata
- Authors
- Place, R., Farovik, A., Brockmann, M., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Venue
- Nature Neuroscience
- Published
- 2016-08
- Volume
- 19
- Issue
- 8
- Pages
- 992-994
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4961615
- OpenAlex
- W2470034833
- Semantic Scholar
- 62121b3f1a5d06bcf2dc7e797e92d8322a273694
- Cited by
- 200
- References
- 25
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 16 · 2023: 16 · 2022: 19 · 2021: 23 · 2020: 23 · 2019: 13 · 2018: 24 · 2017: 28 · 2016: 8
- FWCI
- 15.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH051570, P50MH094263)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- bidirectional information flow, spatial context, hippocampus, prefrontal cortex, functional connectivity, rats
- MeSH terms
- Animals, Behavior, Animal, Hippocampus, Male, Memory, Nerve Net, Neurons, Reward, Prefrontal Cortex, Rats, Long-Evans
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