The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
One-step optogenetics with multifunctional flexible polymer fibers
Open accessAbstract
Optogenetic interrogation of neural pathways relies on delivery of light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest. Despite the recent development of multifunctional neural probes, integration of these modalities in a single biocompatible platform remains a challenge. We developed a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing. Our probes facilitated injections of viral vectors carrying opsin genes while providing collocated neural recording and optical stimulation. The miniature (<200 μm) footprint and modest weight (<0.5 g) of these probes allowed for multiple implantations into the mouse brain, which enabled opto-electrophysiological investigation of projections from the basolateral amygdala to the medial prefrontal cortex and ventral hippocampus during behavioral experiments. Fabricated solely from polymers and polymer composites, these flexible probes minimized tissue response to achieve chronic multimodal interrogation of brain circuits with high fidelity.
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Cites
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Self-citationAmygdala inputs to the ventral hippocampus bidirectionally modulate social behavior
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Direct Pro-Inflammatory Effects of Prorenin on Microglia
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Cited by
Yuk, H., Lu, B., & Zhao, X. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00595h · Cited by 2,108
Yang, J. C., Mun, J., Kwon, S. Y., Park, S., Bao, Z., & Park, S. (2019) · Advanced Materials · doi:10.1002/adma.201904765 · Cited by 1,641
Self-citationNovel electrode technologies for neural recordings
Hong, G., & Lieber, C. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0140-6 · Cited by 695
Bioinspired neuron-like electronics
Yang, X., Zhou, T., Zwang, T. J., Hong, G., Zhao, Y., Viveros, R. D., Fu, T.-M., Gao, T., & Lieber, C. M. (2019) · Nature Materials · doi:10.1038/s41563-019-0292-9 · Cited by 384
From Diagnosis to Treatment: Recent Advances in Patient-Friendly Biosensors and Implantable Devices
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Metadata
- Authors
- Park, S., Guo, Y., Jia, X., Choe, H. K., Grena, B., Kang, J., Park, J., Lu, C., Canales, A., Chen, R., Yim, Y. S., Choi, G. B., Fink, Y., & Anikeeva, P.
- Venue
- Nature Neuroscience
- Published
- 2017-02-20
- Volume
- 20
- Issue
- 4
- Pages
- 612-619
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2590466525
- Cited by
- 381
- References
- 8
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Park, S., Guo, Y., Jia, X., Choe, H. K., Grena, B., Kang, J., Park, J., Lu, C., Canales, A., Chen, R., Yim, Y. S., Choi, G. B., Fink, Y., & Anikeeva, P. (2017). One-step optogenetics with multifunctional flexible polymer fibers. Nature Neuroscience. https://doi.org/10.1038/nn.4510
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