A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

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Items 101–124 of 124

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3. Sex-specific DNA methylation differences in Alzheimer’s disease pathology
   Zhang, Lanyu, Young, Juan I., Gomez, Lissette, Silva, Tiago C., Schmidt, Michael A., Cai, Jesse, Chen, Xi, Martin, Eden R., Wang, Lily · 2021 · Acta Neuropathologica Communications
4. BHLHE40/41 regulate Microglia and Peripheral Macrophage Responses Associated With Alzheimer's Disease and Other Disorders of Lipid‐rich Tissues
   Podleśny-Drabiniok, Anna, Novikova, Gloriia, Liu, Yiyuan, Dunst, Josefine, Temizer, Rose, Giannarelli, Chiara, Marro, Samuele, Kreslavsky, Taras, Marcora, Edoardo, Goate, Alison Mary · 2024 · Nature Communications
5. Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis
   McFarland, Karen N., Chakrabarty, Paramita · 2022 · Neurotherapeutics
6. Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer’s disease
   Jones, Ruth E., Andrews, Robert, Holmans, Peter, Hill, Matthew, Taylor, Philip R. · 2021 · Scientific Reports
7. Genetic risk factors for Alzheimer disease: emerging roles of microglia in disease pathomechanisms
   Takatori, Sho, Wang, Wenbo, Iguchi, Akihiro, Tomita, Taisuke · 2019 · Advances in Experimental Medicine and Biology
8. Human iPSC application in Alzheimer’s disease and tau-related neurodegenerative diseases
   TCW, Julia · 2019 · Neuroscience Letters
9. Comprehensive Analysis of Immune Implications and Prognostic Value of SPI1 in Gastric Cancer
   Huang, Jianfeng, Chen, Wenzheng, Jie, Zhigang, Jiang, Mengmeng · 2022 · Frontiers in Oncology
10. A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation
    Ralvenius, William T., Mungenast, Alison E., Woolf, Hannah, Huston, Margaret M., Gillingham, Tyler Z., Godin, Stephen K., Penney, Jay, Cam, Hugh P., Gao, Fan, Fernandez, Celia G. et al. · 2023 · Journal of Experimental Medicine
11. Translating Alzheimer’s disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs
    Katsumata, Yuriko, Nelson, Peter T., Estus, Steven, Fardo, David W. · 2019 · Neurobiology of Aging
12. Lymphoid gene expression supports neuroprotective microglia function
    Ayata, Pinar, Crowley, Jessica M., Challman, Matthew F., Sahasrabuddhe, Vinaya, Gratuze, Maud, Werneburg, Sebastian, Ribeiro, Diogo, Hays, Emma C., Durán-Laforet, Violeta, Faust, Travis E. et al. · 2025 · Nature
13. Association of SPI1 haplotypes with altered SPI1 gene expression and Alzheimer’s disease risk
    Cao, Han, Alzheimer’s Disease Neuroimaging Initiative, Zhou, Xiaopu, Chen, Yu, Ip, Fanny C.F., Chen, Yuewen, Lai, Nicole C.H., Lo, Ronnie M.N., Tong, Estella P.S., Mok, Vincent C.T. et al. · 2022 · Journal of Alzheimer s Disease
14. Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis
    Kim, Byungwook, Dabin, Luke Child, Tate, Mason Douglas, Karahan, Hande, Sharify, Ahmad Daniel, Acri, Dominic J., Al-Amin, Md Mamun, Philtjens, Stéphanie, Smith, Daniel Curtis, Wijeratne, H. R. Sagara et al. · 2024 · Nature Communications
15. Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms
    Novikova, Gloriia, Kapoor, Manav, TCW, Julia, Abud, Edsel M., Efthymiou, Anastasia G., Cheng, Haoxiang, Fullard, John F., Bendl, Jaroslav, Roussos, Panos, Poon, Wayne W. et al. · 2019
16. Genes, pathways and risk prediction in Alzheimer’s disease
    Hardy, John, Escott-Price, Valentina · 2019 · Human Molecular Genetics
17. Genetic associations with age at dementia onset in the <i>PSEN1 E280A</i> Colombian kindred
    Cochran, Jesse Nicholas, Acosta‐Uribe, Juliana, Esposito, Bianca T., Madrigal, Lucia, Aguillón, David, Giraldo, Margarita M., Taylor, Jared W., Bradley, Joseph, Fulton‐Howard, Brian, Andrews, Shea J. et al. · 2023 · Alzheimer's &amp; Dementia
18. Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer’s Disease Neuropathology and Genetics
    Zajac, Diana J., Simpson, James, Zhang, Eric, Parikh, Ishita, Estus, Steven · 2023 · Genes
19. Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
    Wu, Yi, Guo, Weilin, Kuang, Haoyue, Wu, Xiaohai, Trinh, Thi Huong, Wang, Yuexin, Zhao, Shizheng, Wen, Zilong, Yu, Tao · 2025 · eLife
20. Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models
    Kim, Byungwook, Tate, Mason Douglas, Karahan, Hande, Wijeratne, H.R. Sagara, Sharify, Ahmad Daniel, Wang, Selena S., Kim, Justin R., Al-Amin, Md. Mamun, Hartigan, Kelly, Chung, Sunwoo et al. · 2026 · Neuron
21. Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
    Wu, Yi, Guo, Weilin, Kuang, Haoyue, Wu, Xiaohai, Trinh, Thi Huong, Wang, Yuexin, Zhao, Shizheng, Wen, Zilong, Yu, Tao · 2023 · bioRxiv (Preprint)
22. When less is more and when it isn’t: Microglial Spi1 and the limits of what we know
    Koldamova, Radosveta, Fitz, Nicholas F., Lefterov, Iliya · 2026 · Neuron
23. Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis?
    Chmiel, James, Gawełczyk, Wiktor, Soczyńska, Julia, Leszek, Jerzy · 2026 · Cells
24. Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease
    Kim, Byungwook, Wang, Selena S., Kim, Justin R., Kim, Jungsu · 2026 · BioEssays