Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism
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Abstract
Dysregulation in immune responses during pregnancy increases the risk of a having a child with an autism spectrum disorder (ASD). Asthma is one of the most common chronic diseases among pregnant women, and symptoms often worsen during pregnancy. We recently developed a mouse model of maternal allergic asthma (MAA) that induces changes in sociability, repetitive, and perseverative behaviors in the offspring. Since epigenetic changes help a static genome adapt to the maternal environment, activation of the immune system may epigenetically alter fetal microglia, the brain's resident immune cells. We therefore tested the hypothesis that epigenomic alterations to microglia may be involved in behavioral abnormalities observed in MAA offspring. We used the genome‐wide approaches of whole genome bisulfite sequencing to examine DNA methylation and RNA sequencing to examine gene expression in microglia from juvenile MAA offspring. Differentially methylated regions were enriched for immune signaling pathways and important microglial developmental transcription factor binding motifs. Differential expression analysis identified genes involved in controlling microglial sensitivity to the environment and shaping neuronal connections in the developing brain. Differentially expressed genes significantly overlapped genes with altered expression in human ASD cortex, supporting a role for microglia in the pathogenesis of ASD.
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In microglia isolated from adolescent female mice subject to maternal allergic asthma, WGBS of DMRs shows enrichment of gene sets associated with cytokine signaling pathways.
“In microglia isolated from the whole brain of adolescent female mice subject to maternal allergic asthma exposure, whole-genome-bisulfite sequencing of differentially-methylated regions showed enrichment of gene sets associated with cytokine signaling pathways [129].”
From Cell-type-specific epigenetic effects of early life stress on the brain (2022) · cites this paper as [129]
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Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
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- Authors
- Vogel Ciernia, A., Careaga, M., LaSalle, J. M., & Ashwood, P.
- Affiliations
- Medical Microbiology and Immunology Genome Center, University of California, Davis Davis California 95616
- University of California, Davis (US)
- Corresponding author
- LaSalle, Janine M.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2017-11-14
- Volume
- 66
- Issue
- 3
- Pages
- 505-521
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC5767155
- OpenAlex
- W2765214301
- Cited by
- 69
- References
- 132
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 7
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Glia (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (T32MH073124‐06, 3R01NS081913‐11S1, R21HD086669, R21ES025560, IDDRC U54 HD079125, 5R01NS081913‐14)
- International Rett Syndrome Foundation (7567)
- NCI (P30 CA093373)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- autism spectrum disorder, microglia, epigenetic modifications, DNA methylation, differentially methylated regions, microglial gene expression, fetal brain development, immune signaling pathways, mouse model, behavioral abnormalities, autism pathogenesis
- MeSH terms
- Whole Genome Sequencing, Animals, Asthma, Autistic Disorder, Disease Models, Animal, Female, Hypersensitivity, Mice, Inbred C57BL, Pregnancy, Prenatal Exposure Delayed Effects, Random Allocation, Gene Expression, Sequence Analysis, RNA, Microglia, DNA Methylation, Epigenesis, Genetic, Transcriptome
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