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Synapse-specific astrocyte gating of amygdala-related behavior
Open accessAbstract
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A 1 adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the central amygdala via A 2A receptor activation. Furthermore, astrocytic activation decreased the firing rate of CeM neurons and reduced fear expression in a fear-conditioning paradigm. Therefore, we conclude that astrocyte activity determines fear responses by selectively regulating specific synapses, which indicates that animal behavior results from the coordinated activity of neurons and astrocytes.
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“chemogenetic activation of astrocytes in relevant circuits can affect memory performance 7, 80 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [80]
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Self-citationBrain-wide circuit-specific targeting of astrocytes
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BackgroundInfluentialSelf-citationAstrocytes tune neuronal excitability through the Ca 2+ -activated K + current sIAHPPreprint
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АСТРОЦИТЫ КАК ПОСРЕДНИКИ ИНТЕГРАЦИОННЫХ ПРОЦЕССОВ В МОЗГЕ, "Успехи современной биологии"
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Self-citation
Metadata
- Authors
- Martin-Fernandez, M., Jamison, S., Robin, L. M., Zhao, Z., Martin, E. D., Aguilar, J., Benneyworth, M. A., Marsicano, G., & Araque, A.
- Affiliations
- University of Minnesota (US)
- Université de Bordeaux (FR)
- Servicio de Salud de Castilla La Mancha (ES)
- Corresponding author
- Araque, Alfonso
- Venue
- Nature Neuroscience
- Published
- 2017-09-25
- Volume
- 20
- Issue
- 11
- Pages
- 1540-1548
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5903286
- OpenAlex
- W2759821008
- Cited by
- 345
- References
- 64
- Citations by year
- 2026: 28 · 2025: 51 · 2024: 45 · 2023: 48 · 2022: 44 · 2021: 41 · 2020: 37 · 2019: 29 · 2018: 20 · 2017: 1
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS097312)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, central amygdala, fear expression, fear conditioning, adenosine A1 receptor, adenosine A2A receptor, synaptic transmission, excitatory synapses, inhibitory synapses, basolateral amygdala, astrocyte-neuron interaction, neuronal firing rate
- MeSH terms
- Amygdala, Animals, Astrocytes, Fear, Male, Mice, Inbred C57BL, Nerve Net, Organ Culture Techniques, Synapses, Mice, Knockout, 6-Cyano-7-nitroquinoxaline-2,3-dione, Maze Learning, Receptor, Adenosine A2A, Mice, Adenosine A2 Receptor Antagonists
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