The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Synapse-specific astrocyte gating of amygdala-related behavior
Open accessAbstract
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A 1 adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the central amygdala via A 2A receptor activation. Furthermore, astrocytic activation decreased the firing rate of CeM neurons and reduced fear expression in a fear-conditioning paradigm. Therefore, we conclude that astrocyte activity determines fear responses by selectively regulating specific synapses, which indicates that animal behavior results from the coordinated activity of neurons and astrocytes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“chemogenetic activation of astrocytes in relevant circuits can affect memory performance 7, 80 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [80]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Tripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529
Self-citationTripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820
Self-citationEndogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,595
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Long-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Self-citationCortical pathways to the mammalian amygdala
McDonald, A. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00003-3 · Cited by 1,303
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–345 of 345
Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytesPreprint
Stedehouder, J., Roberts, B. M., Raina, S., Bossi, S., Liu, A. K. L., Doig, N. M., McGerty, K., Magill, P. J., Parkkinen, L., & Cragg, S. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594341
Astrocyte Regulation of Synaptic Plasticity Balances Robustness and Flexibility of Cell AssembliesPreprint
Koshkin, R., & Fukai, T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.08.607120
Astrocytes in Pain Perception: A Systems Neuroscience Approach
Rivera-Villaseñor, A., Higinio-Rodríguez, F., & López-Hidalgo, M. A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_8
Hippocampal astrocytic sequences emerge during learning and memoryPreprint
Senne, R. A., Suthard, R. L., Cao, R., Coello, S., Monasterio, A. H., Ruesch, E. A., Buzharsky, M. D., Howard, M. W., & Ramirez, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.06.611660
Astrocytic regulation of learning and memory
Park, H., Kim, J. S., & Kim, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00060-2
Lamprecht, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00072-9
PepTune: De Novo Generation of Therapeutic Peptides with Multi-Objective-Guided Discrete Diffusion.Preprint
Tang, S., Zhang, Y., & Chatterjee, P. (2025) · PubMed
Animal-based approaches to understanding neuroglia physiology in vitro and in vivo
Gobbo, D., & Kirchhoff, F. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00012-7
Overview of the Endogenous Cannabinoid Signaling System
Stollenwerk, T. M., Ramirez, C. E. M., & Hillard, C. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-87990-6_3
Crooks, A. M., Onuska, K. M., Ngo, G. N., Schmidt, S. D., Hogan-Cann, A. E., Eed, A., Menon, R. S., Saksida, L. M., Bussey, T. J., Schmitz, T. W., et al. (2025) · Lab Animal · doi:10.1038/s41684-025-01587-4
“Most studies have relied on AAV vectors to induce hM3Dq expression 28,29,32 ; thus, it has been argued that astrogliosis and neuroinflammation induced by viral injection may confound the reported behavioral changes 33,34,36 .”
InfluentialZhang, Y., Yang, H., Zhao, Y., Ni, K., Sun, J., & Ma, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115309
Belonio, K. C., Fyke, Z., Haile, E. S., Nadeem, T., & Zak, J. D. (2026) · eNeuro · doi:10.1523/eneuro.0330-25.2026
Genetic-Designed Tools to Unveil the Role of Astrocytes in Neuronal Circuits and Animal Behavior
Ashouri, F., Sánchez-Ruiz, A., Alberquilla, S., & Perea, G. (2025) · Springer eBooks · doi:10.1007/978-3-031-94215-0_5
Endocannabinoid signaling in glial cells
Baraibar, A. M., Sánchez-Martín, E., Colomer, T., Calovi, S., Bernal-Chico, A., & Mato, S. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00005-0
The endocannabinoid signalosome
Gerrikagoitia, I., Río, I. B.-D., Puente, N., & Grandes, P. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00007-4
Endocannabinoid in nonneuronal cells of the CNS
Araque, A., & Noriega‐Prieto, J. A. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00002-5
Self-citationLituma, P. J., Deveci, A., Barrio-Alonso, E., Tan, K., Wilkinson, M., Castillo, P. E., & Çolak, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.18.689044
“Previous studies have also suggested that astrocytic GABAB and A1 receptor signaling pathways contribute to Ca 2+ fluctuations and modulate excitatory transmission, respectively (95-97).”
A glial switch for pain-driven anxiety
Yarur, H. E., Shirley, S. E., Wang, H., & Tejeda, H. A. (2025) · Neuron · doi:10.1016/j.neuron.2025.11.008
Panchumarthy, T., Munoz, L., Saleem, U., Le, A.-V., Nelson, I., Li, Y., Xu, X., & Xu, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.08.698485
Selenoprotein P deletion ameliorates metabolic stress-associated anxiety-like behavior in male mice
Gafiyatullina, G., Shabalova, A. A., Goto, H., Oo, H. K., Saito, K., Tanida, R., Li, Q., Kamoshita, K., Galicia‐Medina, C. M., Nakano, Y., et al. (2026) · Endocrinology · doi:10.1210/endocr/bqag010
de Souza, M. M., Zacharias, L. R., & Leão, R. M. (2026) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2025e15017
Bogaj, K., & Urban‐Ciećko, J. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70456
Circuits neuronaux sous-tendant la régulation émotionnelle par le système ocytocinergique
Goyon, S. (2018) · theses.fr (ABES) · doi:10.70675/c8c9bec0z7b79z4826z862az93b128e1ada6
Role of the type-1 cannabinoid receptor in the control of water intake
Zhao, Z. (2019) · theses.fr (ABES) · doi:10.70675/ca103186z8d92z4d94zaf67zcce657f39cd1
Self-citationRoles of astroglial cannabinoid type 1 receptors (CB1) in memory and synaptic plasticity
Robin, L. M. (2018) · theses.fr (ABES) · doi:10.70675/1fd1dda8z3f4bz404azbdf6z5b648e4c4053
Self-citationNogueira, D. D. S. (2019) · theses.fr (ABES) · doi:10.70675/d429d5dbz5001z4e60z9622z4f636e667f17
The role of astrocytes in the social transmission of stress
Gómez-Sotres, P. (2024) · theses.fr (ABES) · doi:10.70675/1d3b266aze7c4z4968z98c6za5ffe9fe383a
The 3-Body Problem: How Astrocytes May Govern Plasticity
Watanabe, A., Guo, C., & Sjöström, P. J. (2026) · The Neuroscientist · doi:10.1177/10738584261445371
Miftakhov, R., Fortygina, P., Zuzina, A. B., Balaban, P. M., & Borodinova, A. A. (2026) · Scientific Reports · doi:10.1038/s41598-026-56373-0
“Previous studies have shown that activation of the Gq pathway in astrocytes using hM3Dq DREADD receptors triggers calcium release from the endoplasmic reticulum 43,48,49 .”
A central amygdala-locus coeruleus pathway mediating pain under chronic stress
Wei, J., Liu, A., Cao, Y., Fang, J.-M., Chen, Q., Ma, J., Zhu, X., Zhang, Z., Song, Z., & Meng, Q. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117570
Lituma, P. J., Deveci, A., Barrio-Alonso, E., Tan, K., Wilkinson, M., Castillo, P. E., & Colak, D. (2026) · eLife · doi:10.7554/elife.111940
Lituma, P. J., Deveci, A., Barrio-Alonso, E., Tan, K., Wilkinson, M., Castillo, P. E., & Colak, D. (2026) · eLife · doi:10.7554/elife.111940.1
The emerging role of astrocytes in spatial cognition, action and Alzheimer’s disease
Gaborit, M., Arabi, A., & Mariotti, L. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1811370
Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours
Pelaz, S. G., Mitsui, K., Kołosowska, N., Fritch, H. A., Neupane, C., Hull, V. L., Alonso-Gardón, M., Pandey, V., Wang, L., Kawaguchi, R., et al. (2026) · Nature · doi:10.1038/s41586-026-10874-0 · Cited by 1
Motoyoshi, M., & Nagai, J. (2026) · Neuroscience Research · doi:10.1016/j.neures.2026.105103
Konkoly, J., Kormos, V., Szegner, L. M., Biró-Sütő, T., Schram, F., Finsnes, M. A., Bakány, A., Luspay, E., Kumar, P., Kvak, E., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106982
Liao, Y., Zhang, J., Zhao, X., Zhang, G., & Yang, Z. (2026) · Nonlinear Dynamics · doi:10.1007/s11071-026-12939-1
Hippocampal astrocytic sequences emerge during learning and memory recall
Senne, R. A., Suthard, R. L., Cao, R., Coello, S., Monasterio, A., Ruesch, E. A., Buzharsky, M. D., Howard, M. W., & Ramirez, S. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02448-0
Cannabinoid modulation of central amygdala population dynamics during threat investigation
Yasmin, F., Naskar, S., Zaidi, D., Kandil, I. F., Kwon, M., Rosas-Vidal, L. E., & Patel, S. (2026) · Nature Communications · doi:10.1038/s41467-026-77957-4
“First, while CP can induce synaptic depression in the CeA via pre-synaptic CB1 receptors 8 , CB1 on astrocytes have also been shown to indirectly regulate synaptic transmission within the medial CeA 31 .”
The Role of Astrocytes in the Inflammatory Response in Neurodiseases
Peng, S., Wang, L., Ouyang, J., & 刘如恩 (2026) · MedComm · doi:10.1002/mco2.71069
Metadata
- Authors
- Martin-Fernandez, M., Jamison, S., Robin, L. M., Zhao, Z., Martin, E. D., Aguilar, J., Benneyworth, M. A., Marsicano, G., & Araque, A.
- Affiliations
- University of Minnesota (US)
- Université de Bordeaux (FR)
- Servicio de Salud de Castilla La Mancha (ES)
- Corresponding author
- Araque, Alfonso
- Venue
- Nature Neuroscience
- Published
- 2017-09-25
- Volume
- 20
- Issue
- 11
- Pages
- 1540-1548
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5903286
- OpenAlex
- W2759821008
- Cited by
- 345
- References
- 64
- Citations by year
- 2026: 28 · 2025: 51 · 2024: 45 · 2023: 48 · 2022: 44 · 2021: 41 · 2020: 37 · 2019: 29 · 2018: 20 · 2017: 1
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS097312)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, central amygdala, fear expression, fear conditioning, adenosine A1 receptor, adenosine A2A receptor, synaptic transmission, excitatory synapses, inhibitory synapses, basolateral amygdala, astrocyte-neuron interaction, neuronal firing rate
- MeSH terms
- Amygdala, Animals, Astrocytes, Fear, Male, Mice, Inbred C57BL, Nerve Net, Organ Culture Techniques, Synapses, Mice, Knockout, 6-Cyano-7-nitroquinoxaline-2,3-dione, Maze Learning, Receptor, Adenosine A2A, Mice, Adenosine A2 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
