Similar network activity from disparate circuit parameters
Abstract
It is often assumed that cellular and synaptic properties need to be regulated to specific values to allow a neuronal network to function properly. To determine how tightly neuronal properties and synaptic strengths need to be tuned to produce a given network output, we simulated more than 20 million versions of a three-cell model of the pyloric network of the crustacean stomatogastric ganglion using different combinations of synapse strengths and neuron properties. We found that virtually indistinguishable network activity can arise from widely disparate sets of underlying mechanisms, suggesting that there could be considerable animal-to-animal variability in many of the parameters that control network activity, and that many different combinations of synaptic strengths and intrinsic membrane properties can be consistent with appropriate network performance.
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Similar physiological outputs can be produced by variable sets of component parameters.
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Self-citation
- Authors
- Prinz, A. A., Bucher, D., & Marder, E.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Prinz, Astrid A
- Venue
- Nature Neuroscience
- Published
- 2004-11-21
- Volume
- 7
- Issue
- 12
- Pages
- 1345-1352
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2132047598
- Cited by
- 1,091
- References
- 1
- Citations by year
- 2026: 65 · 2025: 54 · 2024: 80 · 2023: 58 · 2022: 78 · 2021: 59 · 2020: 43 · 2019: 92 · 2018: 50 · 2017: 48 · 2016: 31 · 2015: 61 · 2014: 51 · 2013: 53 · 2012: 43
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 46742)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- neuronal network activity, synaptic efficacy, intrinsic membrane properties, stomatogastric ganglion, pyloric network, Crustacea, parameter sensitivity
- MeSH terms
- Action Potentials, Animals, Crustacea, Nerve Net, Neurons, Synapses
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