Postsynaptic Depolarization Scales Quantal Amplitude in Cortical Pyramidal Neurons
Open accessAbstract
Pyramidal neurons scale the strength of all of their excitatory synapses up or down in response to long-term changes in activity, and in the direction needed to stabilize firing rates. This form of homeostatic plasticity is likely to play an important role in stabilizing firing rates during learning and developmental plasticity, but the signals that translate a change in activity into global changes in synaptic strength are poorly understood. Some but not all of the effects of long-lasting changes in activity on synaptic strengths can be accounted for by activity-dependent release of the neurotrophin brain-derived neurotrophic factor (BDNF). Other candidate activity signals include changes in glutamate receptor (GluR) activation, changes in firing rate, or changes in the average level of postsynaptic depolarization. Here we combined elevated KCl (3-12 mm) with ionotropic receptor blockade to dissociate postsynaptic depolarization from receptor activation. Chronic (48 hr) depolarization, ranging between -62 and -36 mV, parametrically reduced the quantal amplitude of excitatory synapses in a BDNF-independent manner. This effect of depolarization did not depend on AMPA, NMDA, or GABA(A) receptor signaling, action-potential generation, or metabotropic GluR activation. Together with previous work, these data suggest that there are two independent signals that regulate activity-dependent synaptic scaling in pyramidal neurons: low levels of BDNF cause excitatory synapses to scale up in strength, whereas depolarization causes excitatory synapses to scale down in strength.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Scaling up can also be induced by chronic changes in the level of depolarization in a BDNF-independent manner.
“However, scaling up can also be induced by chronic changes in the level of depolarization in a BDNF-independent manner (Leslie et al. 2001), and the relationship between BDNF-mediated synaptic scaling and cell-autonomous synaptic scaling of excitatory inputs (Ibata et al. 2008) remains unclear.”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Leslie et al. 2001
The Abstract (page unavailable) says chronic depolarization reduced excitatory quantal amplitude in a BDNF-independent manner—the opposite of scaling up. It attributes scaling up to low levels of BDNF, and the Discussion likewise distinguishes the BDNF-dependent increase from the depolarization-induced decrease. (LLM, conf=0.94)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bienenstock, E., Cooper, L., & Munro, P. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00032.1982 · Cited by 2,896 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Self-citationHuang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198 · see citing works
Requirement for BDNF in activity-dependent survival of cortical neurons
Ghosh, A., Carnahan, J., & Greenberg, M. E. (1994) · Science · doi:10.1126/science.7907431 · Cited by 989 · see citing works
Low access resistance perforated patch recordings using amphotericin B
Rae, J. L., Cooper, K. E., Gates, P., & Watsky, M. A. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90017-t · Cited by 917 · see citing works
Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same
Turrigiano, G. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01341-1 · Cited by 823 · see citing works
Self-citationIsackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711 · see citing works
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688 · see citing works
Hebb and homeostasis in neuronal plasticity
Turrigiano, G. G., & Nelson, S. B. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00091-x · Cited by 687 · see citing works
Self-citationZafra, F., Ċastrén, E., Thoenen, H., & Lindholm, D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10037 · Cited by 580 · see citing works
Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.
Castrén, E., Zafra, F., Thoenen, H., & Lindholm, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9444 · Cited by 513 · see citing works
Ca2+ signaling requirements for long-term depression in the hippocampus.
Cummings, J. A., Mulkey, R., Nicoll, R., & Malenka, R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80102-6 · Cited by 471 · see citing works
Rutherford, L. C., Nelson, S. B., & Turrigiano, G. G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80563-2 · Cited by 451 · see citing works
Self-citationEgger, V., Feldmeyer, D., & Sakmann, B. J. (1999) · Nature Neuroscience · doi:10.1038/16026 · Cited by 405 · see citing works
Shelton, D., Sutherland, J. S., Gripp, J. T., Camerato, T., Armanini, M. P., Phillips, H., Carroll, K., Spencer, S., & Levinson, A. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00477.1995 · Cited by 398 · see citing works
Rutherford, L. C., DeWan, A., Lauer, H. M., & Turrigiano, G. G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04527.1997 · Cited by 381 · see citing works
Self-citationVicario‐Abejón, C., Collin, C., McKay, R. D. G., & Segal, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07256.1998 · Cited by 368 · see citing works
Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses
Watt, A. J., van Rossum, M. C. W., MacLeod, K. M., Nelson, S. B., & Turrigiano, G. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81202-7 · Cited by 350 · see citing works
Self-citationBałkowiec, A., & Katz, D. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07417.2000 · Cited by 332 · see citing works
Lissin, D., Gomperts, S. N., Carroll, R. C., Christine, C. W., Kalman, D., Kitamura, M., Hardy, S. F., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7097 · Cited by 332 · see citing works
Miranda, R. C., Sohrabji, F., & Toran‐Allerand, C. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6439 · Cited by 255 · see citing works
Coexpression of neurotrophins and their receptors in neurons of the central nervous system.
Kokaia, Z., Bengzon, J., METSIS, M. L., Kokaia, M., Persson, H., & Lindvall, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6711 · Cited by 239 · see citing works
Marty, S., Wehrlé, R., & Sotelo, C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08087.2000 · Cited by 237 · see citing works
Mechanism for a sliding synaptic modification threshold
Bear, M. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90056-x · Cited by 237 · see citing works
BDNF Regulates the Intrinsic Excitability of Cortical NeuronsPreprint
Desai, N. S., Rutherford, L. C., & Turrigiano, G. G. (1999) · Learning & Memory · doi:10.1101/lm.6.3.284 · Cited by 199 · see citing works
Self-citationRoles of metabotropic glutamate receptors in LTP and LTD in
Bortolotto, Z. A., Fitzjohn, S. M., & Collingridge, G. L. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80044-0 · Cited by 192 · see citing works
TrkB Receptor Ligands Promote Activity-Dependent Inhibitory Synaptogenesis
Seil, F. J., & Drake‐Baumann, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05367.2000 · Cited by 144 · see citing works
An anatomical substrate for experience-dependent plasticity of the rat barrel field cortex.
Micheva, K. D., & Beaulieu, C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11834 · Cited by 142 · see citing works
Long-term regulation of neuronal calcium currents by prolonged changes of membrane potential
Franklin, J. L., Fickbohm, D., & Willard, A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01726.1992 · Cited by 94 · see citing works
Sawtell, N. B., Huber, K. M., Roder, J., & Bear, M. F. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.3594 · Cited by 36 · see citing works
Upregulation of Calcium Homeostatic Mechanisms in Chronically Depolarized Rat Myenteric Neurons
Fickbohm, D. J., & Willard, A. L. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.2683 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485 · see citing works
Self-citationSynaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
The self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533 · see citing works
Self-citationHomeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · see citing works
Self-citationSimilar network activity from disparate circuit parameters
Prinz, A. A., Bucher, D., & Marder, E. (2004) · Nature Neuroscience · doi:10.1038/nn1352 · Cited by 1,091 · see citing works
Critical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582 · see citing works
Self-citationHOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design
Davis, G. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135751 · Cited by 543 · see citing works
Adaptation to Synaptic Inactivity in Hippocampal Neurons
Thiagarajan, T. C., Lindskog, M., & Tsien, R. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.037 · Cited by 482 · see citing works
Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites
Gorski, J. A., Zeiler, S. R., Tamowski, S., & Jones, K. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06856.2003 · Cited by 411 · see citing works
Bałkowiec, A., & Katz, D. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10399.2002 · Cited by 405 · see citing works
O’Donnell, J., Zeppenfeld, D. M., McConnell, E., Pena, S., & Nedergaard, M. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0818-x · Cited by 373 · see citing works
Homeostatic plasticity and NMDA receptor trafficking
Pérez-Otaño, I., & Ehlers, M. D. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.03.004 · Cited by 356 · see citing works
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
Gottmann, K., Mittmann, T., & Leßmann, V. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1994-z · Cited by 297 · see citing works
Homeostatic signaling: the positive side of negative feedback
Turrigiano, G. G. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.004 · Cited by 285 · see citing works
Self-citationRole of neurotrophins in central synapse formation and stabilization
Vicario‐Abejón, C., Owens, D. F., McKay, R. D. G., & Segal, M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn988 · Cited by 247 · see citing works
Renart, A., Song, P., & Wang, X. (2003) · Neuron · doi:10.1016/s0896-6273(03)00255-1 · Cited by 243 · see citing works
Pickel, V. M., Chan, J., Kash, T. L., Rodrı́guez, J.-J., & Mackie, K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.015 · Cited by 243 · see citing works
Synaptic gain control and homeostasis
Burrone, J., & Murthy, V. N. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.09.007 · Cited by 230 · see citing works
Modeling stability in neuron and network function: the role of activity in homeostasis
Marder, E. E., & Prinz, A. A. (2002) · BioEssays · doi:10.1002/bies.10185 · Cited by 224 · see citing works
Excitation control: balancing PSD-95 function at the synapse
Keith, D. J. (2008) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.004.2008 · Cited by 206 · see citing works
Brain-derived neurotrophic factor and cocaine addiction
McGinty, J. F., Whitfield, T. W., & Berglind, W. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.078 · Cited by 204 · see citing works
De Gois, S., Schäfer, M. K.-H., Defamie, N., Chen, C., Ricci, A., Weihe, E., Varoqui, H., & Erickson, J. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5221-04.2005 · Cited by 192 · see citing works
Mechanisms of homeostatic plasticity in the excitatory synapse
Fernandes, D., & Carvalho, A. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13687 · Cited by 170 · see citing works
Fiete, I. R., Fee, M. S., & Seung, H. S. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01311.2006 · Cited by 167 · see citing works
Houweling, A. R., Bazhenov, M., Timofeev, I., Steriade, M., & B, T. J. S. A. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh184 · Cited by 167 · see citing works
Kang, T., Kim, D., Kwak, S., Kim, J., Won, M. H., Kim, D. W., Choi, S., & Kwon, O. (2006) · Glia · doi:10.1002/glia.20380 · Cited by 142 · see citing works
Regulation of Neuronal Excitability through Pumilio-Dependent Control of a Sodium Channel Gene
Mee, C., Pym, E. C. G., Moffat, K. G., & Baines, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2282-04.2004 · Cited by 137 · see citing works
Corner, M. A., van Pelt, J., Wolters, P. S., Baker, R. E., & Nuytinck, R. H. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00062-8 · Cited by 132 · see citing works
O’Leary, T., van Rossum, M. C. W., & Wyllie, D. J. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181024 · Cited by 118 · see citing works
Sensing and expressing homeostatic synaptic plasticity
Rich, M. M., & Wenner, P. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.004 · Cited by 118 · see citing works
Erasing Synapses in Sleep: Is It Time to Be SHY?
Frank, M. G. (2012) · Neural Plasticity · doi:10.1155/2012/264378 · Cited by 117 · see citing works
Swanwick, C. C., Murthy, N. R., & Kapur, J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.11.002 · Cited by 110 · see citing works
Peng, Y., He, S., Marie, H., Zeng, S.-Y., Ma, J., Tan, Z.-J., Lee, S. Y., Malenka, R. C., & Yu, X. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.015 · Cited by 110 · see citing works
Neuroimmune regulation of homeostatic synaptic plasticity
Pribiag, H., & Stellwagen, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.008 · Cited by 106 · see citing works
Timing-dependent priming effects of tDCS on ankle motor skill learning
Sriraman, A., Oishi, T., & Madhavan, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.021 · Cited by 106 · see citing works
Sleep Promotes Downward Firing Rate Homeostasis
Pacheco, A. T., Bottorff, J., Gao, Y. B., & Turrigiano, G. G. (2020) · Neuron · doi:10.1016/j.neuron.2020.11.001 · Cited by 101 · see citing works
Self-citationMEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons
Tian, X., Li, K., Hockberger, P. E., Wokosin, D. L., & Surmeier, D. J. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.01.012 · Cited by 103 · see citing works
Synaptic homeostasis and input selectivity follow from a calcium-dependent plasticity model
Yeung, L. C., Shouval, H. Z., Blais, B. S., & Cooper, L. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405555101 · Cited by 101 · see citing works
Molecular mechanisms of homeostatic synaptic downscaling
Siddoway, B. A., Hou, H., & Xia, H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.009 · Cited by 91 · see citing works
Rienecker, K. D. A., Poston, R. G., & Saha, R. N. (2020) · ASN NEURO · doi:10.1177/1759091420974807 · Cited by 94 · see citing works
Burkitt, A. N., Hamish Meffin, A., & Grayden, D. B. (2004) · Neural Computation · doi:10.1162/089976604773135041 · Cited by 90 · see citing works
Homeostatic Strengthening of Inhibitory Synapses Is Mediated by the Accumulation of GABAAReceptors
Rannals, M. D., & Kapur, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4476-11.2011 · Cited by 86 · see citing works
Jiao, Y., Zhang, Z., Zhang, C., Wang, X., Sakata, K., Lu, B., & Sun, Q. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105296108 · Cited by 84 · see citing works
AMPAR trafficking in synapse maturation and plasticity
Bassani, S., Folci, A., Zapata, J., & Passafaro, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1309-1 · Cited by 81 · see citing works
Single-Cell Characterization of Retrograde Signaling by Brain-Derived Neurotrophic Factor
Magby, J. P., Bi, C., Chen, Z.-Y., Lee, F. S., & Plummer, M. R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4576-06.2006 · Cited by 71 · see citing works
Dendritic signalling and homeostatic adaptation
Yu, L. M. Y., & Goda, Y. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.07.002 · Cited by 70 · see citing works
Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3
Hruska, M., Henderson, N. T., Xia, N. L., Marchand, S. J. L., & Dalva, M. B. (2015) · Nature Neuroscience · doi:10.1038/nn.4140 · Cited by 64 · see citing works
Reimers, J. M., Loweth, J. A., & Wolf, M. E. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12422 · Cited by 66 · see citing works
A problem with Hebb and local spikes
Goldberg, J. H., Holthoff, K., & Yuste, R. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02200-2 · Cited by 66 · see citing works
Trasande, C. A., & Ramirez, J. (2007) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0b013e318033787f · Cited by 66 · see citing works
Neuron network activity scales exponentially with synapse density
Brewer, G. J., Boehler, M. D., Pearson, R. A., DeMaris, A. A., Ide, A. N., & Wheeler, B. C. (2008) · Journal of Neural Engineering · doi:10.1088/1741-2560/6/1/014001 · Cited by 63 · see citing works
Plastic Elimination of Functional Glutamate Release Sites by Depolarization
Moulder, K. L., Meeks, J. P., Shute, A. A., Hamilton, C. K., de Erausquin, G. A., & Mennerick, S. J. (2004) · Neuron · doi:10.1016/s0896-6273(04)00184-9 · Cited by 61 · see citing works
Mechanisms of GABAergic Homeostatic Plasticity
Wenner, P. (2011) · Journal of Neural Transplantation and Plasticity · doi:10.1155/2011/489470 · Cited by 61 · see citing works
Walmsley, B. D., Berntson, A., Leão, R. N., & Fyffe, R. E. W. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.104851 · Cited by 58 · see citing works
Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling
Gideons, E. S., Lin, P.-Y., Mahgoub, M., Kavalali, E. T., & Monteggia, L. M. (2017) · eLife · doi:10.7554/elife.25480 · Cited by 57 · see citing works
Anti-glutamatergic effect of riluzole: Comparison with valproic acid
Kim, J.-E., Kim, D.-S., Kwak, S., Choi, H.-C., Song, H.-K., Choi, S. Y., Kwon, O.-S., Kim, Y.-I., & Kang, T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.018 · Cited by 56 · see citing works
Physiological Activity Depresses Synaptic Function through an Effect on Vesicle Priming
Moulder, K. L., Jiang, X., Taylor, A. A., Olney, J. W., & Mennerick, S. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5498-05.2006 · Cited by 55 · see citing works
The Interplay Between Homeostatic Synaptic Plasticity and Functional Dendritic Compartments
Rabinowitch, I., & Segev, I. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00074.2006 · Cited by 52 · see citing works
Sun, X., & Wolf, M. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06852.x · Cited by 51 · see citing works
Homeostatic Effects of Depolarization on Ca2+Influx, Synaptic Signaling, and Survival
Moulder, K. L., Cormier, R. J., Shute, A. A., Zorumski, C. F., & Mennerick, S. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01825.2003 · Cited by 48 · see citing works
Wilhelm, J. C., & Wenner, P. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0806037105 · Cited by 49 · see citing works
Neuronal plasticity and thalamocortical sleep and waking oscillations
Timofeev, I. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53839-0.00009-0 · Cited by 44 · see citing works
Lee, K. Y., Royston, S. E., Vest, M. O., Ley, D. J., Lee, S., Bolton, E. C., & Chung, H. J. (2015) · Molecular Brain · doi:10.1186/s13041-015-0094-1 · Cited by 44 · see citing works
Role of Insulin-Like Growth Factors in Neuronal Plasticity and Neuroprotection
Torres‐Alemán, I. (2005) · Advances in experimental medicine and biology · doi:10.1007/0-387-26274-1_10 · Cited by 40 · see citing works
Age dependency of trauma-induced neocortical epileptogenesis
Timofeev, I., B, T. J. S. A., Bazhenov, M., Chauvette, S., & Grand, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00154 · Cited by 38 · see citing works
Chrostowski, M., Yang, L., Wilson, H. R., Bruce, I. C., & Becker, S. (2010) · Journal of Computational Neuroscience · doi:10.1007/s10827-010-0256-1 · Cited by 39 · see citing works
More than a sidekick: glia and homeostatic synaptic plasticity
Turrigiano, G. G. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.08.002 · Cited by 39 · see citing works
Self-citationWherefore Art Thou, Homeo(stasis)? Functional Diversity in Homeostatic Synaptic Plasticity
Queenan, B. N., Lee, K. J., & Pak, D. T. S. (2012) · Neural Plasticity · doi:10.1155/2012/718203 · Cited by 37 · see citing works
Corner, M. A. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.08.001 · Cited by 37 · see citing works
Kato, H., Narita, M., Miyatake, M., Yajima, Y., & Suzuki, T. (2005) · Synapse · doi:10.1002/syn.20213 · Cited by 37 · see citing works
Konishi, Y., Lindholm, K., Yang, L., Li, R., & Shen, Y. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64435-5 · Cited by 37 · see citing works
Jakawich, S. K., Neely, R., Djakovic, S. N., Patrick, G. N., & Sutton, M. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.061 · Cited by 36 · see citing works
Kwak, S., Kim, J., Kim, S. C., Kwon, O., Choi, S., & Kang, T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.04.026 · Cited by 35 · see citing works
Kang, T., Kim, D.-S., Kwak, S., Kim, J.-E., Kim, D. W., Kang, J. H., Won, M., Kwon, O.-S., & Choi, S. Y. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.08.007 · Cited by 35 · see citing works
Kim, D., Kwak, S., Kim, J., Won, M. H., Choi, H., Song, H., Kwon, O., Kim, Y.-I., Choi, S., & Kang, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.081 · Cited by 34 · see citing works
Feedforward Inhibition and Synaptic Scaling – Two Sides of the Same Coin?
Keck, C., Savin, C., & Lücke, J. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002432 · Cited by 32 · see citing works
Rabinowitch, I., & Segev, I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4333-06.2006 · Cited by 31 · see citing works
Volman, V., Bazhenov, M., & B, T. J. S. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112066108 · Cited by 31 · see citing works
Corner, M. A., Baker, R. E., & VANPELT, J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.008 · Cited by 29 · see citing works
Synapse Number and Synaptic Efficacy Are Regulated by Presynaptic cAMP and Protein Kinase A
Munno, D. W., Prince, D. J., & Syed, N. I. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04146.2003 · Cited by 29 · see citing works
Hanno-Iijima, Y., Tanaka, M., & Iijima, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134296 · Cited by 30 · see citing works
Rienecker, K. D. A., Poston, R. G., Segales, J. S., Finholm, I. W., Sono, M. H., Munteanu, S. J., Ghaninejad-Esfahani, M., Rejepova, A., Tejeda-Garibay, S., Wickman, K. D., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102278 · Cited by 26 · see citing works
Homeostatic Regulation of Glutamate Release in Response to Depolarization
Moulder, K. L., Meeks, J. P., & Mennerick, S. (2006) · Molecular Neurobiology · doi:10.1385/mn:33:2:133 · Cited by 26 · see citing works
Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity
Thapliyal, S., Arendt, K. L., Lau, A. G., & Chen, L. (2022) · eLife · doi:10.7554/elife.79863 · Cited by 23 · see citing works
Homeostatic Synaptic Plasticity
Turrigiano, G. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_18 · Cited by 50 · see citing works
Self-citationModeling of Age-Dependent Epileptogenesis by Differential Homeostatic Synaptic Scaling
Gonzalez, O. C., Krishnan, G. P., Chauvette, S., Timofeev, I., B, T. J. S. A., & Bazhenov, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5038-14.2015 · Cited by 23 · see citing works
Copi, A., Jüngling, K., & Gottmann, K. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00155.2005 · Cited by 25 · see citing works
Martín, V., Vale, C., Rubiolo, J. A., Roel, M., Hirama, M., Yamashita, S., Vieytes, M. R., & Botana, L. M. (2015) · Chemical Research in Toxicology · doi:10.1021/tx500506q · Cited by 19 · see citing works
Goel, A., & Buonomano, D. V. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00612.2012 · Cited by 18 · see citing works
Alzheimer β-amyloid blocks epileptiform activity in hippocampal neurons
Sepúlveda, F. J., Opazo, C., & Aguayo, L. G. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.04.012 · Cited by 18 · see citing works
Pawlak, V., Schupp, B. J., Single, F. N., Seeburg, P. H., & Köhr, G. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.076794 · Cited by 17 · see citing works
Homeostatic Plasticity in the Nervous System
Maffei, A., Bucher, D. M., & Fontanini, A. (2012) · Neural Plasticity · doi:10.1155/2012/913472 · Cited by 16 · see citing works
Differential expression of the four untranslated BDNF exons in the adult mouse brain
Malkovska, I., Kernie, S. G., & Parada, L. F. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20728 · Cited by 15 · see citing works
Ueda, A., & Wu, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00010 · Cited by 14 · see citing works
Lu, H., Diaz-Pier, S., Lenz, M., & Vlachos, A. (2023) · eLife · doi:10.7554/elife.88376 · Cited by 14 · see citing works
Rapid Homeostatic Plasticity in the Intact Adult Visual System
Riegle, K. C., & Meyer, R. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1631-07.2007 · Cited by 13 · see citing works
Intrinsic adaptive plasticity in mouse and human sensory neurons
McIlvried, L. A., Rosario, J. S. D., Pullen, M. Y., Wangzhou, A., Sheahan, T. D., Shepherd, A. J., Slivicki, R. A., Lemen, J. A., Price, T. J., Copits, B. A., et al. (2024) · The Journal of General Physiology · doi:10.1085/jgp.202313488 · Cited by 10 · see citing works
Lu, H., Diaz-Pier, S., Lenz, M., & Vlachos, A. (2025) · eLife · doi:10.7554/elife.88376.3 · Cited by 10 · see citing works
Timofeev, I., Chauvette, S., & Soltani, S. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-418693-4.00002-9 · Cited by 10 · see citing works
Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits
Wen, W., Prada, A. M., & Turrigiano, G. G. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2504775122 · Cited by 12 · see citing works
Self-citation
- Authors
- Leslie, K. R., Nelson, S. B., & Turrigiano, G. G.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Turrigiano, Gina G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-10-01
- Volume
- 21
- Issue
- 19
- Pages
- RC170-RC170
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762907
- OpenAlex
- W2163758015
- Cited by
- 128
- References
- 31
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 3 · 2017: 1 · 2016: 2 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 6
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9726944)
- National Institutes of Health (5k02ns001893-03)
- National Institute of Neurological Disorders and Stroke (R01 NS-36853, K02 NS01893, R01NS036853)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- postsynaptic depolarization, synaptic scaling, homeostatic plasticity, cortical pyramidal neurons, excitatory synapses, brain-derived neurotrophic factor, AMPA receptors, NMDA receptor, GABAA receptor, metabotropic glutamate receptors
- MeSH terms
- Action Potentials, Animals, Astrocytes, Calcium Channel Blockers, Cells, Cultured, Cerebral Cortex, Membrane Potentials, Neuronal Plasticity, Potassium Chloride, Synapses, Signal Transduction, Pyramidal Cells, Receptors, Metabotropic Glutamate, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, GABA Antagonists, Coculture Techniques, Brain-Derived Neurotrophic Factor, Excitatory Postsynaptic Potentials, Calcium Channels, L-Type, Receptor, trkB, Rats, GABA-A Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
