αCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory

The MAPK cascade is required for mammalian associative learning

Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083 · see citing works

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055 · see citing works

Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation

Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049 · see citing works

Neuronal Ca2+/calmodulin-dependent protein kinases.

Hanson, P., & Schulman, H. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.003015 · Cited by 628 · see citing works

A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties

Si, K., Lindquist, S. L., & Kandel, E. R. (2003) · Cell · doi:10.1016/s0092-8674(03)01020-1 · Cited by 565 · see citing works

The CaM kinase II hypothesis for the storage of synaptic memory.

Lisman, J. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90014-0 · Cited by 526 · see citing works

A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.

Lisman, J. E. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.9.3055 · Cited by 475 · see citing works

The consolidation of new but not reactivated memory requires hippocampal C/EBPβ

Taubenfeld, S. M., Milekic, M. H., Monti, B., & Alberini, C. M. (2001) · Nature Neuroscience · doi:10.1038/90520 · Cited by 420 · see citing works

Visualization of the Distribution of Autophosphorylated Calcium/Calmodulin-Dependent Protein Kinase II after Tetanic Stimulation in the CA1 Area of the Hippocampus

Ouyang, Y., Kantor, D. B., Harris, K. M., Schuman, E. M., & Kennedy, M. B. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05416.1997 · Cited by 227 · see citing works

Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeys

Baxter, M. G., & Murray, E. A. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 186 · see citing works

Post-training amygdaloid lesions impair retention of an inhibitory avoidance response

Liang, K., McGaugh, J. L., Martinez, J. L., Jensen, R. A., Vásquez, B. J., & Messing, R. B. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90002-x · Cited by 155 · see citing works

Pavlovian Fear Conditioning Regulates Thr286Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II at Lateral Amygdala Synapses

Rodrigues, S. M., Farb, C. R., Bauer, E. P., LeDoux, J. E., & Schafe, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5303-03.2004 · Cited by 134 · see citing works

Autonomous activity of CaMKII is only transiently increased following the induction of long‐term potentiation in the rat hippocampus

Lengyel, I., Voss, K. L., Cammarota, M., Bradshaw, K., Brent, V. A., Murphy, K., Giese, K.-P., Rostas, J. A. P., & Bliss, T. V. P. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03748.x · Cited by 101 · see citing works

Protected‐Site Phosphorylation of Protein Kinase C in Hippocampal Long‐Term Potentiation

Sweatt, J. D., Atkins, C. M., Johnson, J. E., English, J., Roberson, E. D., Chen, S., Newton, A. C., & Klann, E. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71031075.x · Cited by 57 · see citing works

Handling and environmental enrichment do not rescue learning and memory impairments in αCamKIIT286A mutant mice

Need, A. C., & Giese, K.-P. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00020.x · Cited by 47 · see citing works

Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear

Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,778 · see citing works

Neural Mechanisms of Extinction Learning and Retrieval

Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works

The roles of protein kinases in learning and memoryPreprint

Giese, K.-P., & Mizuno, K. (2013) · Learning & Memory · doi:10.1101/lm.028449.112 · Cited by 229 · see citing works

The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation

Finnie, P. S. B., & Nader, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.008 · Cited by 189 · see citing works

CaMKII Isoforms in Learning and Memory: Localization and Function

Zalcman, G., Federman, N., & Romano, A. G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00445 · Cited by 185 · see citing works

Interactions between the NR2B Receptor and CaMKII Modulate Synaptic Plasticity and Spatial Learning

Zhou, Y., Takahashi, E., Li, W., Halt, A., Wiltgen, B., Ehninger, D., Li, G.-D., Hell, J. W., Kennedy, M. B., & Silva, A. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-07.2007 · Cited by 179 · see citing works

Dendritic spikes induce single-burst long-term potentiation

Remy, S., & Spruston, N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707919104 · Cited by 179 · see citing works

Calmodulin kinases: essential regulators in health and disease

Takemoto‐Kimura, S., Suzuki, K., Horigane, S., Kamijo, S., Inoue, M., Sakamoto, M., Fujii, H., & Bito, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14020 · Cited by 171 · see citing works

CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca 2+ Signals during LTP Induction, but Not Maintenance

Chang, J.-Y., Parra-Bueno, P., Laviv, T., Szatmari, E. M., Lee, S.-J. R., & Yasuda, R. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.041 · Cited by 161 · see citing works

CaMKII "Autonomy" Is Required for Initiating But Not for Maintaining Neuronal Long-Term Information Storage

Buard, I., Coultrap, S. J., Freund, R. K., Lee, Y.-S., Dell'Acqua, M. L., Silva, A. J., & Bayer, K. U. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1469-10.2010 · Cited by 160 · see citing works

Activity-driven postsynaptic translocation of CaMKII

Merrill, M. A., Chen, Y., Strack, S., & Hell, J. W. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.003 · Cited by 148 · see citing works

Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase II  in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0707-09.2009 · Cited by 146 · see citing works

c-Rel, an NF-κB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formationPreprint

Ahn, H. J., Hernandez, C. M., Levenson, J. M., Lubin, F. D., Liou, H.-C., & Sweatt, J. D. (2008) · Learning & Memory · doi:10.1101/lm.866408 · Cited by 144 · see citing works

3,4-Methylenedioxymethamphetamine facilitates fear extinction learning

Young, M. B., Andero, R., Ressler, K. J., & Howell, L. L. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.138 · Cited by 141 · see citing works

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor

Murakoshi, H., Shin, M. E., Parra-Bueno, P., Szatmari, E. M., Shibata, A. C. E., & Yasuda, R. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.036 · Cited by 140 · see citing works

The role of NR4A transcription factors in memory formation

Hawk, J. D., & Abel, T. G. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.02.001 · Cited by 128 · see citing works

Fear conditioning and extinction: emotional states encoded by distinct signaling pathways

Tronson, N. C., Corcoran, K. A., Jovasevic, V., & Radulović, J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.003 · Cited by 120 · see citing works

Intra‐gastrointestinal amyloid‐β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology

Sun, Y., Sommerville, N. R., Liu, J. Y. H., Ngan, M. P., Poon, D., Ponomarev, E. D., Lu, Z., Kung, J. S. C., & Rudd, J. A. (2020) · The Journal of Physiology · doi:10.1113/jp279919 · Cited by 116 · see citing works

Regulation of Nuclear Factor κB in the Hippocampus by Group I Metabotropic Glutamate Receptors

O’Riordan, K. J., Huang, I.-C., Pizzi, M., Spano, P., Boroni, F., Egli, R. E., Desai, P., Fitch, O., Malone, L. M., Ahn, H. J., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4527-05.2006 · Cited by 112 · see citing works

Dysregulated phosphorylation of Ca2+/calmodulin‐dependent protein kinase II‐α in the hippocampus of subjects with mild cognitive impairment and Alzheimer’s disease

Reese, L. C., Laezza, F., Woltjer, R. L., & Taglialatela, G. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07447.x · Cited by 99 · see citing works

Mechanism for long-term memory formation when synaptic strengthening is impaired

Radwanska, K., Medvedev, N. I., Pereira, G. S., Engmann, O., Thiede, N., Moraes, M. F. D., Villers, A., Irvine, E. E., Maunganidze, N. S., Pyza, E. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109680108 · Cited by 97 · see citing works

Novel insights into CaMKII function and regulation during memory formation

Lucchesi, W., Mizuno, K., & Giese, K.-P. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.10.009 · Cited by 95 · see citing works

Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage

Rossetti, T., Banerjee, S., Kim, C., Leubner, M., Lamar, C., Gupta, P., Lee, B., Neve, R., & Lisman, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.010 · Cited by 94 · see citing works

αCaMKII autophosphorylation: a fast track to memory

Irvine, E. E., von Hertzen, L. S. J., Plattner, F., & Giese, K.-P. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.06.009 · Cited by 92 · see citing works

Lymnaea stagnalis as model for translational neuroscience research: From pond to bench

Rivi, V., Benatti, C., Colliva, C., Radighieri, G., Brunello, N., Tascedda, F., & Blom, J. M. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.020 · Cited by 77 · see citing works

“The seven sins” of the Hebbian synapse: Can the hypothesis of synaptic plasticity explain long-term memory consolidation?

Arshavsky, Y. I. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.09.004 · Cited by 74 · see citing works

Memory consolidation induces N-methyl-d-aspartic acid-receptor- and Ca2+/calmodulin-dependent protein kinase II-dependent modifications in α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor properties

Bevilaqua, L. R., Medina, J. H., Izquierdo, I., & Cammarota, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.007 · Cited by 69 · see citing works

C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm

Stein, G. M., & Murphy, C. T. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.07.011 · Cited by 68 · see citing works

The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders

Sałaciak, K., Koszałka, A., Żmudzka, E., & Pytka, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094307 · Cited by 66 · see citing works

αCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior

Easton, A. C., Lucchesi, W., Lourdusamy, A., Lenz, B., Solati, J., Golub, Y., Lewczuk, P., Fernandes, C., Desrivières, S., Dawirs, R. R., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.60 · Cited by 64 · see citing works

Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells

Chi, M., Evans, H. M., Gilchrist, J., Mayhew, J., Hoffman, A., Pearsall, E., Jankowski, H., Brzozowski, J. S., & Skelding, K. A. (2016) · Scientific Reports · doi:10.1038/srep33132 · Cited by 64 · see citing works

NMDA receptor‐dependent long‐term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca ²⁺ /calmodulin‐dependent kinases

Lamsa, K., Irvine, E. E., Giese, K. P., & Kullmann, D. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.137380 · Cited by 61 · see citing works

Role of Ca2+/Calmodulin-Dependent Protein Kinase Type II in Mediating Function and Dysfunction at Glutamatergic Synapses

Mohanan, A. G., Gunasekaran, S., Jacob, R. S., & Omkumar, R. V. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.855752 · Cited by 57 · see citing works

RNA interference in hippocampus demonstrates opposing roles for CREB and PP1α in contextual and temporal long‐term memory

Peters, M., Bletsch, M., Catapano, R., Zhang, X., Tully, T., & Bourtchouladze, R. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00474.x · Cited by 56 · see citing works

Investigating the molecular mechanisms of learning and memory using Caenorhabditis elegans

Rahmani, A., & Chew, Y. L. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15510 · Cited by 52 · see citing works

A revised view of the role of CaMKII in learning and memory

Bayer, K. U., & Giese, K.-P. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01809-x · Cited by 50 · see citing works

Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy

Zhao, P., Shi, W., Ye, Y., Xu, K., Hu, J., Chao, H., Tao, Z., Xu, L., Gu, W., Zhang, L., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103156 · Cited by 49 · see citing works

Genome-Wide Association for Fear Conditioning in an Advanced Intercross Mouse Line

Parker, C. C., Sokoloff, G., Cheng, R., & Palmer, A. A. (2012) · Behavior Genetics · doi:10.1007/s10519-011-9524-8 · Cited by 47 · see citing works

Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: Correlation with AMPA receptor subunit expression in rat hippocampus

Schiapparelli, L., Simón, A. M., del Rı́o, J. A., & Frechilla, D. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.02.005 · Cited by 46 · see citing works

Hippocampal Wnt3a is Necessary and Sufficient for Contextual Fear Memory Acquisition and Consolidation

Xu, N., Zhou, W., Wang, Y., Huang, S., Li, X., & Chen, Z.-Y. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu121 · Cited by 45 · see citing works

CaMKII is differentially localized in synaptic regions of kenyon cells within the mushroom bodies of the honeybee brain

Pasch, E., Muenz, T. S., & Rößler, W. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22683 · Cited by 45 · see citing works

Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation

Devinney, M. J., Nichols, N. L., & Mitchell, G. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4122-15.2016 · Cited by 45 · see citing works

Autophosphorylation of αCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinctionPreprint

Kimura, R., Silva, A. J., & Ohno, M. (2008) · Learning & Memory · doi:10.1101/lm.1049608 · Cited by 44 · see citing works

Delayed Noradrenergic Activation in the Dorsal Hippocampus Promotes the Long-Term Persistence of Extinguished Fear

Chai, N., Liu, J., Xue, Y.-X., Yang, C., Yan, W., Wang, H.-M., Luo, Y., Shi, H., Wang, J.-S., Bao, Y., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.42 · Cited by 41 · see citing works

Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities

Migues, P. V., Lehmann, I. T., Fluechter, L., Cammarota, M., Gurd, J. W., Sim, A. T. R., Dickson, P. W., & Rostas, J. A. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03876.x · Cited by 41 · see citing works

ERK1/2 and CaMKII-mediated events in memory formation: Is 5HT regulation involved?

Cammarota, M., Bevilaqua, L. R., Medina, J. H., & Izquierdo, I. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.029 · Cited by 40 · see citing works

An endogenous inhibitor of calcium/calmodulin‐dependent kinase II is up‐regulated during consolidation of fear memory

Lepicard, E. M., Mizuno, K., Antunes‐Martins, A., von Hertzen, L. S. J., & Giese, K.-P. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04830.x · Cited by 40 · see citing works

Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor

Vigil, F. A., Mizuno, K., Lucchesi, W., Valls-Comamala, V., & Giese, K.-P. (2017) · Scientific Reports · doi:10.1038/s41598-017-04355-8 · Cited by 38 · see citing works

The role of CaMKII autophosphorylation for NMDA receptor-dependent synaptic potentiation

Giese, K.-P. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108616 · Cited by 38 · see citing works

Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity

Olivito, L., Saccone, P., Perri, V., Bachman, J. L., Fragapane, P., Mele, A., Huganir, R. L., & Leonibus, E. D. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0927-1 · Cited by 36 · see citing works

CaM Kinases: From Memories to Addiction

Müller, C. P., Quednow, B. B., Lourdusamy, A., Kornhuber, J., Schumann, G., & Giese, K.-P. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.11.001 · Cited by 36 · see citing works

Protein kinase signaling in synaptic plasticity and memory

Mayford, M. R. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.05.001 · Cited by 35 · see citing works

Differential effects of αCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability

Ohno, M., Sametsky, E. A., Silva, A. J., & Disterhoft, J. F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04746.x · Cited by 34 · see citing works

αCaMKII controls the establishment of cocaine's reinforcing effects in mice and humans

Easton, A. C., Lourdusamy, A., Havranek, M. M., Mizuno, K., Solati, J., Golub, Y., Clarke, T., Vallada, H., Laranjeira, R., Desrivières, S., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.97 · Cited by 34 · see citing works

Properties of Contextual Memory Formed in the Absence of αCaMKII Autophosphorylation

Irvine, E. E., Danhiez, A., Radwańska, K., Nassim, C., Lucchesi, W., Godaux, E., Ris, L., & Giese, K.-P. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-8 · Cited by 34 · see citing works

The role of post‐translational modifications for learning and memory formation

Sunyer, B., Diao, W., & Lübec, G. (2008) · Electrophoresis · doi:10.1002/elps.200700791 · Cited by 34 · see citing works

Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

Philips, G. T., Kopec, A. M., & Carew, T. J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.05.003 · Cited by 33 · see citing works

Alpha-isoform of Ca2+/calmodulin-dependent kinase II autophosphorylation is required for memory consolidation-specific transcription

von Hertzen, L. S. J., & Giese, K.-P. (2005) · Neuroreport · doi:10.1097/01.wnr.0000175244.51084.bb · Cited by 33 · see citing works

Generation of multi-innervated dendritic spines as a novel mechanism of long-term memory formation

Giese, K.-P., Aziz, W., Kraev, I., & Stewart, M. G. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.04.009 · Cited by 32 · see citing works

Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety

Yen, Y.-C., Mauch, C. P., Dahlhoff, M., Micale, V., Bunck, M., Sartori, S. B., Singewald, N., Landgraf, R., & Wotjak, C. T. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.009 · Cited by 31 · see citing works

Delayed Intrinsic Activation of an NMDA-Independent CaM-kinase II in a Critical Time Window Is Necessary for Late Consolidation of an Associative Memory

Wan, H., Mackay, B., Iqbal, H., Naskar, S., & Kemenes, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2577-09.2010 · Cited by 30 · see citing works

αCaMKII autophosphorylation controls exploratory activity to threatening novel stimuli

Easton, A. C., Lucchesi, W., Schumann, G., Giese, K.-P., Müller, C. P., & Fernandes, C. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.036 · Cited by 30 · see citing works

A role for calcium‐calmodulin‐dependent protein kinase II in the consolidation of visual object recognition memory

Tinsley, C. J., Narduzzo, K. E., Ho, J. W., Barker, G. R., Brown, M. W., & Warburton, E. C. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06917.x · Cited by 29 · see citing works

Ca2+/calmodulin protein kinase II and memory: learning‐related changes in a localized region of the domestic chick brain

Solomonia, R. O., Kotorashvili, A., Kiguradze, T., McCabe, B. J., & Horn, G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098012 · Cited by 28 · see citing works

Calcium/calmodulin‐dependent kinase II and memory destabilization: a new role in memory maintenance

Vigil, F. A., & Giese, K.-P. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14454 · Cited by 28 · see citing works

Fear conditioning: Insights into learning, memory and extinction and its relevance to clinical disorders.

Trent, S., Abdullah, M. H., Parwana, K. A. K., Valdivieso, M. A., Hassan, Z., & Müller, C. (2025) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111310 · Cited by 27 · see citing works

Aberrant Rho GTPases signaling and cognitive dysfunction: In vivo evidence for a compelling molecular relationship

Filippis, B. D., Romano, E., & Giovanni Laviola, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.007 · Cited by 25 · see citing works

Autophosphorylation of alpha isoform of calcium/calmodulin‐dependent kinase II regulates alcohol addiction‐related behaviors

Harda, Z., Łukasiewicz, K., Ziółkowska, M., Lipiński, M., Cały, A., Matuszek, Ż., Łęski, S., & Radwańska, K. (2015) · Addiction Biology · doi:10.1111/adb.12327 · Cited by 25 · see citing works

Defining memories by their distinct molecular traces

Sossin, W. S. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.001 · Cited by 24 · see citing works

Autophosphorylation of αCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation

Sametsky, E. A., Disterhoft, J. F., & Ohno, M. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.02.006 · Cited by 23 · see citing works

CAMK2A polymorphisms predict working memory performance in humans

Easton, A. C., Lourdusamy, A., Loth, E., Torro, R., Giese, K.-P., Kornhuber, J., de Quervain, D. J. ‐., Papassotiropoulos, A., Fernandes, C., Müller, C. P., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.114 · Cited by 22 · see citing works

Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis

Rosell‐Valle, C., Pedraza, C., Manuel, I., Moreno‐Rodríguez, M., Rodríguez‐Puertas, R., Castilla‐Ortega, E., Caramés, J. M., Gómez-Conde, A. I., Zambrana-Infantes, E. N., Ortega-Pinazo, J., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110156 · Cited by 21 · see citing works

Th e Role of Protein Phosphorylation in the Gustatory Cortex and Amygdala During Taste Learning

Adaikkan, C., & Rosenblum, K. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.2.37 · Cited by 21 · see citing works

LTP expression mediated by autonomous activity of GluN2B-bound CaMKII

Rumian, N. L., Barker, C. M., Larsen, M. E., Tullis, J. E., Freund, R. K., Taslimi, A., Coultrap, S. J., Tucker, C. L., Dell’Acqua, M. L., & Bayer, K. U. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114866 · Cited by 20 · see citing works

Long-lasting behavioral effects in neonatal mice with multiple exposures to ketamine-xylazine anesthesia

Huang, L., Hayes, S., & Yang, G. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.09.003 · Cited by 20 · see citing works

Ischemia and status epilepitcus result in enhanced phosphorylation of calcium and calmodulin-stimulated protein kinase II on threonine 253

Gurd, J. W., Rawof, S., Huo, J. Z., Dykstra, C. M., Bissoon, N., Teves, L. M., Wallace, M. C., & Rostas, J. A. P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.04.040 · Cited by 20 · see citing works

Genes and neurons: molecular insights to fear and anxiety

Stoppel, C., Albrecht, A., Pape, H., & Stork, O. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00229.x · Cited by 20 · see citing works

Phosphorylation of PSD-95 at serine 73 in dCA1 is required for extinction of contextual fear

Ziółkowska, M., Borczyk, M., Cały, A., Nalberczak‐Skóra, M., Śliwińska, M. A., Robacha, M., Łukasiewicz, K., Skonieczna, E., Tomaszewski, K. F., Tomaszewski, K. F., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002106 · Cited by 18 · see citing works

CaMKII binding to GluN2B is important for massed spatial learning in the Morris water maze

Stein, I. S., Donaldson, M. S., & Hell, J. W. (2014) · F1000Research · doi:10.12688/f1000research.4660.1 · Cited by 18 · see citing works

Enhanced CaMKII activity and spatial cognitive function in SAMP6 mice.

Takahashi, E., Niimi, K., & Itakura, C. (2009) · Behavioral Neuroscience · doi:10.1037/a0015119 · Cited by 17 · see citing works

In memoriam: John Lisman – commentaries on CaMKII as a memory molecule

Bear, M. F., Cooke, S. F., Giese, K.-P., Kaang, B., Kennedy, M. B., Kim, J., Morris, R., & Park, P. (2018) · Molecular Brain · doi:10.1186/s13041-018-0419-y · Cited by 17 · see citing works

Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII

Śliwińska, M. A., Cały, A., Borczyk, M., Ziółkowska, M., Skonieczna, E., Chilimoniuk, M., Bernaś, T., Giese, K.-P., & Radwańska, K. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz261 · Cited by 16 · see citing works

Differential regulation of CaMKII inhibitor β protein expression after exposure to a novel context and during contextual fear memory formation

Radwańska, K., Jones, A. A. T., Mizuno, K., Pereira, G. S., Lucchesi, W., Alfano, I., Lach, A. A., Kaczmarek, L., Knapp, S., & Giese, K.-P. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00595.x · Cited by 16 · see citing works

Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation

Villers, A., Giese, K. P., & Ris, L. (2014) · Learning & Memory · doi:10.1101/lm.035972.114 · Cited by 16 · see citing works

Formation of long-term memory without short-term memory revealed by CaMKII inhibition

Shin, M. E., Parra-Bueno, P., & Yasuda, R. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01831-z · Cited by 15 · see citing works

αCaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice

Schöpf, I., Easton, A. C., Solati, J., Golub, Y., Kornhuber, J., Giese, K.-P., & Müller, C. P. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.02.031 · Cited by 15 · see citing works

Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model

Wang, J., Liu, J., Pan, L., Qi, R., Liu, P., Zhou, W., & Cai, Y. (2017) · Scientific Reports · doi:10.1038/srep43385 · Cited by 15 · see citing works

Autophosphorylation of αCaMKII affects social interactions in mice

Harda, Z., Dzik, J. M., Nalberczak‐Skóra, M., Meyza, K. Z., Łukasiewicz, K., Łęski, S., & Radwańska, K. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12457 · Cited by 14 · see citing works

Hippocampal receptor complexes paralleling LTP reinforcement in the spatial memory holeboard test in the rat

Subramaniyan, S., Hajali, V., Scherf, T., Sase, S., Sialana, F. J., Gröger, M., Bennett, K. L., Pollak, A. J., Li, L., Korz, V., et al. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.036 · Cited by 13 · see citing works

Differential Involvement of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase IIα in Hippocampus- and Amygdala-Dependent Memory Revealed by Kinase-Dead Knock-In Mouse

Yamagata, Y., Yanagawa, Y., & Imoto, K. (2018) · eNeuro · doi:10.1523/eneuro.0133-18.2018 · Cited by 12 · see citing works

Ocular dominance plasticity is stably maintained in the absence of α calcium calmodulin kinase II (αCaMKII) autophosphorylation

Taha, S. A., & Stryker, M. P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508185102 · Cited by 12 · see citing works

Egr-1 antisense oligodeoxynucleotide administration into the olfactory bulb impairs olfactory learning in the greater short-nosed fruit bat Cynopterus sphinx

Ambigapathy, G., Bogdanowicz, W., Balamurugan, K., Varman, D. R., & Rajan, K. E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.038 · Cited by 11 · see citing works

Long-lasting transcription in hippocampal area CA1 after contextual fear conditioning

Mizuno, K., Jeffries, A. R., Abel, T. G., & Giese, K.-P. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107250 · Cited by 11 · see citing works

Long-Term Potentiation and Memory

(2012) · Springer eBooks · doi:10.1007/springerreference_169302 · Cited by 10 · see citing works

Mapping fear memory consolidation and extinction-specific expression of JunB

Radwańska, K., Pereira, G. S., Ziółkowska, M., Łukasiewicz, K., & Giese, K.-P. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.08.007 · Cited by 9 · see citing works

Characterization of Senescence-Accelerated Mouse Prone 6 (SAMP6) as an Animal Model for Brain Research

Niimi, K., & Takahashi, E. (2014) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.63.1 · Cited by 9 · see citing works

Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability

Fujii, H., Kidokoro, H., Kondo, Y., Kawaguchi, M., Horigane, S., Natsume, J., Takemoto‐Kimura, S., & Bito, H. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.970031 · Cited by 8 · see citing works

Projections from thalamic nucleus reuniens to medial septum enable extinction of remote fear memory

Tomaszewski, K. F., Gajewska‐Woźniak, O., Ziółkowska, M., Łukasiewicz, K., Cały, A., Sotoudeh, N., Puchalska, M., Salamian, A., & Radwańska, K. (2026) · Acta Neurobiologiae Experimentalis · doi:10.55782/zd27ss41 · Cited by 7 · see citing works

CaMKII is activated in opioid induced conditioned place preference, but αCaMKII Thr286 autophosphorylation is not necessary for its establishment

Andersen, J. M., Opdal, S. H., Müller, C. P., & Boix, F. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112676 · Cited by 7 · see citing works

NMDA receptor-targeted enrichment of CaMKIIα improves fear memory

Chifor, A., Choi, J., & Park, J. (2022) · iScience · doi:10.1016/j.isci.2022.104864 · Cited by 6 · see citing works

ACaMKII autophosphorylation contributes to rapid learning but is not necessary for memory

Irvine, E., Vernon, J. D. R., & Giese, K.-P. (2005) · UCL Discovery (University College London)

αCaMKII autophosphorylation: a fast track to memory

Irvine, E. E., von Hertzen, L. S. J., Plattner, F., & Giese, K.-P. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.06.009 · Cited by 92 · see citing works

alpha CaMKII autophosphorylation: a fast track to memory

Irvine, E., von Hertzen, L., Plattner, F., & Giese, K.-P. (2006) · UCL Discovery (University College London)

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055 · see citing works

CaMKII Autophosphorylation-Dependent Learning and Memory

Vigil, F. A., & Giese, K.-P. (2015) · Springer eBooks · doi:10.1007/978-3-319-24364-1_4