A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.
Open accessAbstract
A mechanism is proposed for a molecular switch that can store information indefinitely, despite the complete turnover of the molecules that make up the switch. The design of the switch is based on known types of biochemical reactions. Central to the mechanism is a kinase that is activated by phosphorylation and capable of intermolecular autophosphorylation. It is shown that such a kinase and an associated phosphatase form a bistable chemical switch that can be turned on by an external stimulus and that is not reset by protein turnover.
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Crick and Lisman proposed a molecular model for information storage that could withstand molecular turnover.
“As discussed above, they proposed a molecular model for information storage that could withstand molecular turnover.”
From Synaptic memory and CaMKII (2023) · cites this paper as [8]
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BackgroundIs Persistent Activity of Calcium/Calmodulin-Dependent Kinase Required for the Maintenance of LTP?
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- Authors
- Lisman, J. E.
- Corresponding author
- Lisman, J E
- ORCID
- Lisman, J E
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1985-05
- Volume
- 82
- Issue
- 9
- Pages
- 3055-3057
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC397705
- OpenAlex
- W1978730538
- Cited by
- 475
- References
- 1
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 12 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 14 · 2019: 13 · 2018: 13 · 2017: 10 · 2016: 18 · 2015: 15 · 2014: 18 · 2013: 15 · 2012: 14
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › stochastic dynamics and bifurcation
- Keywords
- autophosphorylation, kinases, phosphatase, memory storage, protein turnover, molecular switches, phosphorylation, information storage
- MeSH terms
- Memory, Models, Neurological, Nervous System Physiological Phenomena, Neurons, Phosphoric Monoester Hydrolases, Phosphorylation, Phosphotransferases
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