The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The first neurons of the human cerebral cortex
Abstract
We describe a distinctive, widespread population of neurons situated beneath the pial surface of the human embryonic forebrain even before complete closure of the neural tube. These 'predecessor' cells include the first neurons seen in the primordium of the cerebral cortex, before the onset of local neurogenesis. Morphological analysis, combined with the study of centrosome location, regional transcription factors and patterns of mitosis and neurogenesis, indicates that predecessor cells invade the cortical primordium by tangential migration from the subpallium. These neurons, described here for the first time, precede all other known cell types of the developing cortex.
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“the developing human CNS possesses certain divergent and highly derived features, such as expanded proliferative zones and diverse subtypes of neural stem and progenitor cells with enhanced proliferative capacities that facilitate brain expansion, especially of the neocortex (Bae et al., 2015; Bystron et al., 2006; Dehay et al., 2015; Gulden and Sestan, 2014; Howard et al., 2008; Lui et al., 2011;”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Bystron et al., 2006
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Cites
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462
Englund, C., Fink, A., Lau, C., Pham, D., Daza, R. A. M., Bulfone, A., Kowalczyk, T., & Hevner, R. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2899-04.2005 · Cited by 1,261
Neuronal migration, with special reference to developing human brain: a review
Sidman, R. L., & RAKIC, P. T. (1973) · Brain Research · doi:10.1016/0006-8993(73)90617-3 · Cited by 1,260
Haubensak, W. E., Attardo, A., Denk, W. T., & Huttner, W. Β. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308600100 · Cited by 1,004
C ELL M IGRATION IN THE F OREBRAIN
Marín, Ó., & Rubenstein, J. L. R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131058 · Cited by 957
Tbr1 regulates differentiation of the preplate and layer 6
Hevner, R. F., Shi, L., Justice, N., Hsueh, Y.-P., Sheng, M., Smiga, S., Bulfone, A., Goffinet, A. M., Campagnoni, A. T., & Rubenstein, J. L. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00211-2 · Cited by 857
Lavdas, A. A., Grigoriou, M., Pachnis, V., & Parnavelas, J. G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07881.1999 · Cited by 765
Origin of GABAergic neurons in the human neocortex
Letinić, K., Zoncu, R., & RAKIC, P. T. (2002) · Nature · doi:10.1038/nature00779 · Cited by 730
Embryonic vertebrate central nervous system: Revised terminology
Angevine, J. B., Bodian, D., Coulombre, A. J., Edds, M. V., Hamburger, V., Jacobson, M., Lyser, K. M., Prestige, M. C., Sidman, R. L., Varon, S. S., et al. (1970) · The Anatomical Record · doi:10.1002/ar.1091660214 · Cited by 727
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Research works printed but not linked: 2
- Carney, R.S.E., Bystron, I., Blakemore, C., Molnár, Z. & López-Bendito, G. Radial glial cell proliferation outside the proliferative zone: A quantitative study in fetal rat and human cortex. FENS Forum Abstr. 2, 145.4 (2004).
- Committee to Review the Guidance on the Research Use of Fetuses and Fetal Material. Review of the guidance on the research use of fetuses and fetal material (Her Majesty's Stationery Office, London 1989).
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Sorted by citations
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565
Self-citationDevelopment of the human cerebral cortex: Boulder Committee revisited
Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977
Self-citationThe Cellular and Molecular Landscapes of the Developing Human Central Nervous System
Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M., & Sestan, N. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.008 · Cited by 818
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655
Chambers, S. M., Qi, Y., Mica, Y., Lee, G., Zhang, X., Niu, L., Bilsland, J., Cao, L., Stevens, E. B., Whiting, P. J., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2249 · Cited by 604
Metadata
- Authors
- Bystron, I., Rakic, P., Molnár, Z., & Blakemore, C.
- Affiliations
- University of Oxford (GB)
- Yale University (US)
- Corresponding author
- Bystron, Irina
- Venue
- Nature Neuroscience
- Published
- 2006-06-18
- Volume
- 9
- Issue
- 7
- Pages
- 880-886
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1969413827
- Cited by
- 183
- References
- 44
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- Russian Foundation for Basic Research
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- cortical development, tangential migration, subpallium, transcription factors, mitosis, neurogenesis, neural tube closure
- MeSH terms
- Cell Differentiation, Cell Movement, Cerebral Cortex, Fetus, Humans, Immunohistochemistry, Nerve Tissue Proteins, Neurons, Stem Cells, Transcription Factors, Gene Expression, Body Patterning
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