The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex
Abstract
Feedforward inhibitory GABAergic transmission is critical for mature cortical circuit function; in the neonate, however, GABA is depolarizing and believed to have a different role. Here we show that the GABAA receptor-mediated conductance is depolarizing in excitatory (stellate) cells in neonatal (postnatal day [P]3-5) layer IV barrel cortex, but GABAergic transmission at this age is not engaged by thalamocortical input in the feedforward circuit and has no detectable circuit function. However, recruitment occurs at P6-7 as a result of coordinated increases in thalamic drive to fast-spiking interneurons, fast-spiking interneuron-stellate cell connectivity and hyperpolarization of the GABAA receptor-mediated response. Thus, GABAergic circuits are not engaged by thalamocortical input in the neonate, but are poised for a remarkably coordinated development of feedforward inhibition at the end of the first postnatal week, which has profound effects on circuit function at this critical time in development.
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“However, the connectivity between these interneurons and excitatory neurons in layer 4 remains relatively weak until the second postnatal week, when PV+ basket cells begin receiving direct inputs from thalamic neurons (Chittajallu and Isaac, 2010; Daw et al., 2007).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Daw et al., 2007
Citations
Cites
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Cortex is driven by weak but synchronously active thalamocortical synapses
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Cited by
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Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714
Cruikshank, S. J., Urabe, H., Nurmikko, A. V., & Connors, B. W. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.025 · Cited by 459
GABAergic Interneurons Shape the Functional Maturation of the Cortex
Le Magueresse, C., & Monyer, H. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.011 · Cited by 425
Feldmeyer, D., Brecht, M., Helmchen, F., Petersen, C. C. H., Poulet, J. F. A., Staiger, J. F., Luhmann, H. J., & Schwarz, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.11.002 · Cited by 354
“In addition to this disynaptic feed-forward mechanism, trisynaptic feedback inhibition via reciprocal synapse between spiny stellate and inhibitory neurons with a high connectivity ratio exists as well (Kölbl et al., 2010; Cruikshank et al., 2007; Daw et al., 2007).”
BackgroundInput normalization by global feedforward inhibition expands cortical dynamic range
Pouille, F., Marin-Burgin, A., Adesnik, H., Atallah, B. V., & Scanziani, M. (2009) · Nature Neuroscience · doi:10.1038/nn.2441 · Cited by 306
Metadata
- Authors
- Daw, M. I., Ashby, M. C., & Isaac, J. T. R.
- Affiliations
- University of Bristol (GB)
- National Institutes of Health (US)
- Corresponding author
- Isaac, John T R
- Venue
- Nature Neuroscience
- Published
- 2007-03-11
- Volume
- 10
- Issue
- 4
- Pages
- 453-461
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1964470295
- Cited by
- 174
- References
- 47
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 4 · 2019: 4 · 2018: 13 · 2017: 16 · 2016: 16 · 2015: 8 · 2014: 13 · 2013: 7 · 2012: 8
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- fast-spiking interneurons, stellate cells, feedforward inhibition, GABAA receptor, neonatal development, thalamocortical input, GABAergic neurotransmission, cortical circuit development, postnatal development
- MeSH terms
- Action Potentials, Age Factors, Animals, Animals, Newborn, Bicuculline, Cerebral Cortex, Dose-Response Relationship, Radiation, Electric Stimulation, Interneurons, Mice, Transgenic, Neural Pathways, Thalamus, Patch-Clamp Techniques, GABA Antagonists, Excitatory Postsynaptic Potentials, Green Fluorescent Proteins, Mice, In Vitro Techniques
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